56 research outputs found
Poles of the Standard -function of and the Rallis–Schiffmann Lift
No full textAbstractWe characterize the cuspidal representations ofwhose standard-function admits a pole atas the image of the Rallis–Schiffmann lift for the commuting pair (,) in. The image consists of non-tempered representations. The main tool is the recent construction, by the second author, of a family of Rankin–Selberg integrals representing the standard-function.</jats:p
In Vitro-Modellierung pharmakologischer Inhibition der Histon-Desacetylase-Aktivität in Lungenkarzinom-Zellen
No full textLong-term prognostic counselling in people with multiple sclerosis using an online analytical processing tool
No full textBackground: prognostic counselling is a sensitive issue in medicine and especially so in MS due to the highly heterogeneous disease course. However, people with MS (pwMS) seek prognostic information. The web-based ‘Evidence-Based Decision Support Tool in Multiple Sclerosis’ (EBDiMS) uses data of 717 patients from the London/Ontario cohort to calculate personalized long-term prognostic information. Objective: the aim of this study was to investigate the feasibility and effect of long-term prognostic counselling in pwMS using EBDiMS. Methods: ninety consecutive pwMS were provided with personalized estimations of expected time to reach Expanded Disability Status Scale (EDSS) scores of 6 and 8 and time to conversion to secondary-progressive MS. Participants gave estimates on their own putative prognosis and rated the tool’s acceptability on six-step Likert-type scales. Results: participants rated EBDiMS as highly understandable, interesting and relevant for patient–physician encounters, coping and therapy decisions. Although it provoked a certain degree of worry in some participants, 95% would recommend using the tool. Participants’ own prognosis estimates did not change significantly following EBDiMS. Conclusion: long-term prognostic counselling using an online tool has been shown to be feasible in a clinical setting. EBDiMS provides pwMS with relevant, easy-to-understand, long-term prognostic information without causing relevant anxiety.</p
Corrigendum to “Active subspaces for the optimal meanline design of unconventional turbomachinery” (Applied Thermal Engineering (2017) 127 (1108–1118), (S1359431117315466) (10.1016/j.applthermaleng.2017.08.093))
No full textBy means of this corrigendum, the authors would like to include relevant information regarding the validation of the meanline turbine model employed in the original article. The improvement regarding the validation of the model was made possible thanks to the contribution of Prof. Jürg Schiffmann. The additional results documented here provide more confidence on the reliability of the model when it applied to mini-ORC turbines. Therefore, we kindly ask the Editor to add his name to the authors list. The following paragraph extends the one that discusses the meanline validation located in Section 2. The turbine preliminary design is performed by means of a meanline code, which is based on the loss models listed in Ref. [1]. These models have been developed for conventional turbomachinery operating with fluids in the ideal gas state, featuring subsonic flows and large Reynolds numbers. The meanline code has been validated with the results of literature test cases presenting these characteristics [2]. It has been also compared against an experimentally validated turbine model for mORC machines operating in the subsonic regime [3]. Table 1 shows the information of the machine geometry for which results of the two codes were compared, while Fig. 1 presents the meridional channel of the turbine. Table 2 shows the corresponding operating conditions. The results of the total-to-static efficiency computation are presented in Fig. 2. It can be observed that the efficiency trend obtained with zTurbo is similar to that computed with the validated EPFL code. The comparison between the two models suggests a deviation lower than 2.5% for all the tested operating conditions. This deviation occurs because each model uses a different set of loss correlations. These correlations are described in Refs. [1,3].Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
Magnetresonanztomographie bei Multipler Sklerose verstehen lernen: Entwicklung und Pilotierung eines Online-Schulungsprogramms zur Magnetresonanztomographie für Menschen mit Multipler Sklerose
No full textHintergrund und Zielsetzung:
Menschen mit Multipler Sklerose (MS) verfügen über ein geringes Wissen zur Magnetresonanztomographie (MRT) sowie zu ihrer Erkrankung selbst.
Dies ist konträr zur Relevanz der MRT-Untersuchung für das Krankheitsmanagement und stellt ein Hindernis für die aktive Teilnahme an medizinischen Entscheidungsprozessen dar. Umfassende, patientenfreundliche und evidenzbasierte Patienteninformationen zu Nutzen und Limitation der MRT bei MS sind für Betroffene derzeit nicht verfügbar. Ziel dieser Studie war die Entwicklung und Pilotierung eines patientenfreundlichen, interaktiven und evidenzbasierten Online-Schulungsprogramms zur MRT bei MS. Die Website UMIMS (Understanding MRI in MS) soll das MRT-Risikowissen verbessern, Ängste ab- und MRT-Kompetenz aufbauen, um eine aktive Rollenpräferenz in der Arzt-Patienten-Beziehung zu fördern.
Methoden:
Die Entwicklung basierte auf einer Literaturrecherche sowie der Vorarbeit von Brand et al. (2014). Während des Entwicklungsprozesses wurde die Website in 2 semistrukturierten Interviewrunden mit Menschen mit MS, Expert-Patienten und MRT-Experten evaluiert. In der Pilotstudie erhielten n = 92 Menschen mit MS für 4 Wochen Zugang zur Website. Die Benutzererfahrungen und die Akzeptanz, das MRT-Risikowissen (Fragebogen MRI-RIKNO 2.0) sowie die Emotionen und Einstellungen gegenüber der MRT (Fragebogen MRI-EMA) wurden evaluiert. Die Ergebnisse wurden mit einer früheren Online-Kohorte mit n = 508 Menschen mit MS ohne Zugang zur Website verglichen.
Ergebnisse:
Die Teilnehmenden der Pilotkohorte beschrieben überwiegend eine Darstellung aller wichtigen Informationen zum Thema MRT bei MS sowie eine angemessene Informationsfülle. Für die Mehrheit waren die Informationen neu, ohne zu verunsichern. In einer Gegenüberstellung mit einer früheren Online-Kohorte ohne Zugang zur Website wurde in der Pilotkohorte eine relevante Steigerung des MRT-Risikowissens um 9,9 % durchschnittlich richtig beantworteter Fragen im MRI-RIKNO 2.0 Fragebogen erzielt (Pilotkohorte: 72,0 %, Online-Kohorte: 62,1 %). Die MRT vermittelte den Teilnehmenden der Pilot- sowie der Online-Kohorte ein moderates Gefühl von Kontrolle über ihre Erkrankung. Allerdings gaben 66,3 % der Teilnehmenden der Pilotkohorte an sich kompetent genug zu fühlen, um ihre MRT-Ergebnisse mit einem Arzt zu diskutieren, in der Online-Kohorte waren es nur 46,9 %. Die Teilnehmenden hatten nur wenig Angst vor dem MRT-Scan selbst, es bestand jedoch eine moderate Angst vor den MRT-Ergebnissen. Beides war in der Pilot- und Online-Kohorte vergleichbar.
Schlussfolgerung:
Die hohe Akzeptanz der Website sowie die erzielte Wissenssteigerung zeigen die Relevanz und Notwendigkeit von evidenzbasierten Patienteninformationen zur MRT bei MS.
Ein gestiegenes Kompetenzgefühl kann Menschen mit MS bei Entscheidungsprozessen dazu befähigen, eine aktive Rollenpräferenz zu verwirklichen, insbesondere bei Entscheidungen, die sich auf MRT-Befunde stützen und hilft möglicherweise auch, Ängste in Bezug auf die MRT zu reduzieren
Epigenetic priming of non-small cell lung cancer cell lines to the antiproliferative and differentiating effects of all-trans retinoic acid
No full text
The PBW basis of
No full textWe consider the PBW basis of the type A quantum toroidal algebra developed by
the author, and prove commutation relations between its generators akin to the
ones studied by Burban-Schiffmann for n=1. This gives rise to a new
presentation of the quantum toroidal algebra of type A.Comment: Significant enhancements over previous versions. We give two
orthogonal (in a certain sense) generators-and-relations presentations of the
quantum toroidal algebra. Improved presentation, with road map provided for
each Sectio
A new methodology in network reliability
No full textComputer networks have turned out to be a more and more indispensable way of electronic communication. Not only the internet with its vast number of networked computers but also local or regional high-speed data networks are on their way to replace any other classical communication equipment like telephone, video conferences, radio, television, magazines, newspapers but also sensitive control devices. This makes the user of electronic media increasingly dependent on the proper functioning of the devices and connections which build the basic components of communication networks. This dissertation contributes to optimizing the dependability of highperformance networks. Graph-theoretical considerations combined with examinations of real-world networks and their predicted developments lead to a test framework which is used to analyze a novel high-speed restoration methodology which is capable of rapid calculation of network restoration paths. The methodology supports an arbitrary number of node and link failures in point-to-point or point-to-multipoint networks. Besides this universal approach, as far as the author knows, the algorithm reveals the lowest runtime of all currently presented restoration algorithms for general network graphs. Its operation is simulated on specially elaborated random graph models which can be tuned to represent most of the network topologies that currently exist. An additional chapter presents new methods for gaining a single similarity index, which allows the comparing of graph topologies. Finally the prediction of the structural development of existing network topologies is discussed. Models of this kind allow realistic performance and behavior tests in not yet existing network structures
Counting absolutely cuspidals for quivers
No full text20 pages, Latex; integrality theorem proved, some references added, most notably to a 2003 paper of B. Deng, J. Xiao establishing polynomiality of cuspidal countInternational audienceFor an arbitrary quiver Q = (I, Ω) and dimension vector d ∈ N I we define the dimension of absolutely cuspidal functions on the moduli stacks of representations of dimension d of a quiver Q over a finite field Fq, and prove that it is a polynomial in q, which we conjecture to be positive and integral. We obtain a closed formula for these dimensions of spaces of cuspidals for totally negative quivers
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