304 research outputs found
Sevoflurane-induced retrograde amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.
No full text富山大学博士（医学）Article富山大学・富医薬博甲第354号・亀山 暁世・2020/09/30
公表論文
Akiyo Kameyama, Hirotaka Asai, Masanori Nomoto, Shuntaro Ohno, Khaled Ghandour, Noriaki Ohkawa, Yoshito Saitoh, Mitsuaki Yamazaki, Kaoru Inokuchi; Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning. Biol Open 15 December 2022; 11 (12): bio059666. doi: https://doi.org/10.1242/bio.05966
On the description of nature and the feeling of Kaoru, the hero in the Tale of Genji, to Uji
No full text源氏物語の宇治の自然描写は、登場人物の心情と関連している。都と宇治の環境の違い、宇治の姉妹との人間関係、描写される音楽から、薫の精神的探求を述べる。The author researches a visit made by Kaoru, the hero in the Tale of Genji, to Uji, a suburb of Kyoto. This paper analyses; 1) the differences in the atmosphere of Uji and Kyoto. 2) the interaction between Kaoru and the beautiful sisters he meets when hearing heavenly music, and 3) the effect of this encounter on the mind of the hero himself
Role of adult neurogenesis in hippocampal-cortical memory consolidation
No full textAcquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision
Non-associative place memory is precisely maintained during the reorganization process of neuronal substrates underlying remote memory formation
No full textLack of a requirement for strict rotational alignment among transcription factor binding sites in yeast
No full textThe MFa1 gene of Saccharomyces cerevisiae is an a specific gene whose expression is regulated by two upstream activation sites (UASMFa1s), which are the binding sites for activator proteins, MATal and MCM1. UASMFa1 elements act in a synergistic fashion; lack of either element causes reduced expression levels that are 6- to 45-fold less than that of intact promoter in a cells. We investigated the effect of manipulating rotational alignments among transcription factor binding sites of MFa1 on the expression of the gene. The expression level of MFal decreased with the spacing between the two UASMFa1s and no synergism was observed when the distance of the two elements was longer than 90 base pairs. No strict rotational alignment was required for their synergistic action. We also show that the spacing between UASMFa1 elements and TFIID binding site, the TATA box, had little, if any, effect on MFa1 expression. We chose a sufficient number of positions for UASMFa1s to ensure that, in several of these positions, MATal and MCM1 were on the opposite side of the DNA helix with respect to the TATA box
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