18 research outputs found
Variance in teacher perceptions of school misbehavior, their estimation of misbehavior prevalence and burnout
No full text"Four questions were posed to investigate relationships among teacher perceptions of misbehavior seriousness, estimations of misbehavior prevalence and burnout. These were: (a) How can perceptions of seriousness be described? (b) How can variance in perceptions be explained? (c) How can reported incidence of misbehavior prevalence and burnout be described? and (d) How can relationships among these three variables be predicted? Instrument packets containing the School Misbehavior Rating Form (assessing misbehavior seriousness), The Estimation of Misbehavior Prevalence Form and the Maslach Burnout Inventory were distributed to 443 Illinois public school teachers in one urban, one suburban and one rural district. Two hundred and twenty-three usable packets were returned. Analyses revealed that SMRF data were normally distributed, and misbehavior seriousness rankings were similar across grade levels and districts. Two factors accounting for greater than 92% of SMRF variance emerged and were named ""crisis"" and ""everyday"" misbehavior. These factors correlated differently among low, middle and high SMRF scorers. Analysis of variance findings showed that teachers' subject area, birth order and gender balance of siblings contributed significantly to variance in ""everyday"" misbehavior ratings. ""Crisis"" rating variance was similarly explained by geographic mobility prior to high school, and by occupation and education of mother and father. Descriptive findings were computed for misbehavior prevalence and burnout. Multiple regression analyses revealed numerous significant relationships among the attendant factors of the three instruments. An example supporting frame of reference theory was that high levels of burnout in association with high SMRF scores appeared to predict the level of misbehavior incidence. In general, findings supported the posited hypothetical relationships among perceptions, prevalence and burnout. It was concluded that, because of the relative nature of misbehavior, standardized behavioristic discipline systems may be ""naturally"" inequitable. The use of findings from these instruments was recommended as a means of clarifying teacher values, and as a point of entry toward the consensus definition of misbehavior. Because of the ecological nature of misbehavior and burnout, future research and intervention should focus on the interactions of teacher, parent and student perceptions."Made available in DSpace on 2011-05-07T12:40:05Z (GMT). No. of bitstreams: 2
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Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
No full textBackground CV9103 is a prostate-cancer vaccine containing self-adjuvanted mRNA (RNActive®) encoding the antigens PSA, PSCA, PSMA, and STEAP1. This phase I/IIa study evaluated safety and immunogenicity of CV9103 in patients with advanced castration-resistant prostate-cancer. Methods 44 Patients received up to 5 intra-dermal vaccinations. Three dose levels of total mRNA were tested in Phase I in cohorts of 3–6 patients to determine a recommended dose. In phase II, 32 additional patients were treated at the recommended dose. The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. Results The most frequent adverse events were grade 1/2 injection site erythema, injection site reactions, fatigue, pyrexia, chills and influenza-like illness. Possibly treatment related urinary retention occurred in 3 patients. The recommended dose was 1280 μg. A total of 26/33 evaluable patients treated at 1280 μg developed an immune response, directed against multiple antigens in 15 out of 33 patients. One patient showed a confirmed PSA response. In the subgroup of 36 metastatic patients, the Kaplan-Meier estimate of median overall survival was 31.4 months [95 % CI: 21.2; n.a]. Conclusions The self-adjuvanted RNActive® vaccine CV9103 was well tolerated and immunogenic. The technology is a versatile, fast and cost-effective platform allowing for creation of vaccines. The follow-up vaccine CV9104 including the additional antigens prostatic acid phosphatase (PAP) and Muc1 is currently being tested in a randomized phase IIb trial to assess the clinical benefit induced by this new vaccination approach. Trial registration EU Clinical Trials Register: EudraCT number 2008-003967-37 , registered 27 Jan 2009
A randomized controlled trial of an appearance-based dietary intervention
No full textObjective: Inadequate fruit and vegetable consumption precipitates preventable morbidity and mortality. The efficacy of an appearance-based dietary intervention was investigated, which illustrates the beneficial effect that fruit and vegetable consumption has on skin appearance. Methods: Participants were randomly allocated to three groups receiving information-only or a generic or own-face appearance-based intervention. Diet was recorded at baseline and 10 weekly follow-ups. Participants in the generic and own-face intervention groups witnessed on-screen stimuli and received printed photographic materials to illustrate the beneficial effect of fruit and vegetable consumption on skin color. Results: Controlling for baseline diet, a significant effect of intervention group was found on self-reported fruit and vegetable intake among 46 completers who were free of medical and personal reasons preventing diet change. The own-face appearance-based intervention group reported a significant, sustained improvement in fruit and vegetable consumption whereas the information-only and generic appearance-based intervention groups reported no significant dietary changes. Conclusions: Seeing the potential benefits of fruit and vegetable consumption on own skin color may motivate dietary improvement.Peer reviewe
Interview on the role of landscape architect
No full textFrom climate change to sustainable communities, landscape architecture is at the forefront of todays most crucial issues and this book provides an introduction to the key elements of this broad field. The Fundamentals of Landscape Architecture explains the process of designing for sites, calling upon historical precedent and evolving philosophies to discuss how a project moves from concept to realization. It serves as a guide to the many specializations within landscape architecture, such as landscape strategy and urban design. The second edition features new international and US-based case studies including a study of Peter Schaudt of Hoerr Schaudt Landscape Architects based in Chicago, US, which features the Historic Landscape Preservation Plan, at The University of North Carolina, Chapel Hill. The work of Dr Kongjian Yu of Turenscape is explored and features Houtan Park, Shanghai, China and Greg Grabasch's project Januburu Six Seasons, Broome, Western Australia is discussed. Examined in depth is the work of Ten Eyck Landscape Architects at The Arizona State University Polytechnic Campus, US. For the second edition the author, Tim Waterman, has interviewed the following leading landscape architects: Phil Askew of the London Legacy Development Corporation, UK, discusses the continuing legacy of the Olympics in London. The work of New York-based Thomas Balsley is explored through his project at Hunter's Point South Waterfront Park, New York, USA. The ethos of Raymond Jungles is examined with reference to his project at 1111 Lincoln Road, Miami, Florida, USA. And the role of the landscape architect is discussed with Thierry Kandjee of Taktyk in Brussels, Belgium. These interviews and case studies should inspire landscape architect students the world over to create innovative and creative designs.info:eu-repo/semantics/publishe
Therapeutic anti‐tumor immunity triggered by injections of immunostimulating single‐stranded RNA
No full textStabilized synthetic RNA oligonucleotides (ORN) and protected messenger RNA (mRNA) were recently discovered to possess an immunostimulatory capacity through their recognition by TLR 7 and 8. We wanted to find out whether this danger signal is capable of triggering anti-tumor immunity when injected locally into an established tumor. Using the mouse glioma tumor cell line SMA-560 in syngenic VM/Dk mice, we were able to show that intra-tumor injections of protamine-stabilized mRNA do indeed induce tumor regression and long-term anti-tumor immunity. Residual RNA-injected tumors show CD8 infiltration. Distant injections of protamine-protected mRNA and intra-tumor injection of naked mRNA also result in anti-tumor immunity. Although they are strong danger signals, RNA are labile molecules with a short half-life: they do not trigger side effects such as long-term, uncontrolled immunostimulation evidenced by splenomegaly in CpG DNA-treated mice. In conclusion, RNA molecules are potent and safe danger signals that are relevant for active immunotherapy strategies aimed at the eradication of solid tumor
Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients
No full textToll-like receptor-dependent activation of several human blood cell types by protamine-condensed mRNA
No full textDistinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy
No full textABSTRACT We recently completed a phase I/IIa trial of RNActive® CV9201, a novel mRNA-based therapeutic vaccine targeting five tumor-associated antigens in non-small cell lung cancer (NSCLC) patients. The aim of the study presented here was to comprehensively analyze changes in peripheral blood during the vaccination period and to generate hypotheses facilitating the identification of potential biomarkers correlating with differential clinical outcomes post RNActive® immunotherapy. We performed whole-genome expression profiling in a subgroup of 22 stage IV NSCLC patients before and after initiation of treatment with CV9201. Utilizing an analytic approach based on blood transcriptional modules (BTMs), a previously described, sensitive tool for blood transcriptome data analysis, patients segregated into two major clusters based on transcriptional changes post RNActive® treatment. The first group of patients was characterized by the upregulation of an expression signature associated with myeloid cells and inflammation, whereas the other group exhibited an expression signature associated with T and NK cells. Patients with an enrichment of T and NK cell modules after treatment compared to baseline exhibited significantly longer progression-free and overall survival compared to patients with an upregulation of myeloid cell and inflammatory modules. Notably, these gene expression signatures were mutually exclusive and inversely correlated. Furthermore, our findings correlated with phenotypic data derived by flow cytometry as well as the neutrophil-to-lymphocyte ratio. Our study thus demonstrates non-overlapping, distinct transcriptional profiles correlating with survival warranting further validation for the development of biomarker candidates for mRNA-based immunotherapy.Version of Recor
