104 research outputs found
Idiopathic guttate hypomelanosis: An overview
No full textIdiopathic guttate hypomelanosis is a commonly acquired, benign leukoderma characterized by multiple, discrete round or oval, porcelain-white macules on sun-exposed areas, especially the extensor aspect of forearms and shins, sparing the face, neck, and trunk. It usually affects the geriatric population (>50 years); chronic exposure to ultraviolet rays and senile degeneration being the important pathogenic factors. The diagnosis remains essentially clinical, whereas newer confirmatory investigations are emerging. Despite the benign course of progression, many patients seek medical attention owing to cosmetic concerns. Several treatment modalities have been tried over time including topical, physical, and surgical measures, although there is lack of a standard treatment regime. In this article, we have reviewed the different aspects of this condition including treatment, along with the recent updates to create awareness about this dermatological entity
Multiple eccrine hydrocystoma masquerading as papular sarcoidosis in a patient suffering from systemic sarcoidosis
No full textGlobal research trend on allergic skin disorders: A bibliometric analysis from 2001 to 2020
No full textBackground: Allergic skin disorders constitute a variety of inflammatory skin disorders with increasing incidence. Bibliometric studies involve a statistical analysis of academic literature to assess the current research trend and identify knowledge gaps. There is a dearth of such studies concerning allergic skin disorders. Aim: To perform a bibliometric analysis of global research concerning allergic skin disorders from 2001 to 2020. Materials and Methods: We obtained all data from the Web of Science using the keywords “atopic dermatitis,” “contact dermatitis,” “skin allergy,” “urticaria,” “food allergy,” and “drug allergy.” Only articles in English language were included. Subsequent analysis revealed the total number of publications, top journals, institutions, and countries, thus highlighting the overall research trend. Results: Overall 76,764 articles were published on allergic skin disorders from 2001 to 2020 (original articles > review articles). The United States of America (USA) contributed maximum publications (26.1%) followed by Germany (9.6%), Japan (8.2%), and England (8.1%). The Allergy is the most preferred journal for publishing skin allergy research. Most research concentrated on atopic dermatitis, pathomechanisms of allergic disorders, and their primary prevention. Conclusion: This study evaluates the current landscape of skin allergy research. There has been a consistent increase in the number of publications concerning allergic skin disorders over the years. However, majority of the research publications are from developed countries. Hence, skin allergy-related research publication should be increased for diverse and enriched literary evidences
Pigmentary disorders and their management–analyzing current evidence: Conference proceedings and learning points. Pigmentarycon 2017. November 10–12, Indore, India
No full text
Loeffler′s syndrome following cutaneous larva migrans: An uncommon sequel
No full textCutaneous larva migrans (CLM) is characterized by the formation of distinctive, tortuous, and serpentine skin lesions occurring as a result of epidermal burrowing by certain helminthic larvae. Although this condition is usually uneventful, rarely it may result in patchy pulmonary infiltration with peripheral eosinophilia, also called Loeffler's syndrome. This association is fairly uncommon and is thus being reported
Clinical and Histopathological response to multidrug therapy in paucibacillary leprosy at the end of 6 Months: A prospective observational study from eastern India
No full textBackground: At present, the WHO recommends fixed duration multidrug therapy (FD-MDT) for the treatment of leprosy, in which treatment is provided for a fixed duration regardless of clearance of skin lesions or bacterial status of the patient. There is divided opinion regarding the efficacy of FD-MDT; especially for paucibacillary Hansen's disease, in which treatment is provided for 6 months. In addition, there is a paucity of literature on clinical and histopathological features of treated leprosy. Objectives: The objectives of this study were to prospectively observe the effects of MDT on clinical and histopathological features in paucibacillary leprosy and to assess the efficacy, safety and tolerability of MDT-paucibacillary (PB) regimen. Materials and Methods: A total of 52 new cases of PB leprosy diagnosed by clinicopathological correlation and slit skin smear were administered standard WHO PB-MDT for 6 months. Patients were reviewed at 3rd month and 6th month of therapy and 3 months posttherapy for their clinical and histopathological assessment. Results: Among 52 new cases of PB-leprosy 43 patients (mean age 31.74 ± 12.2 years, m:f 1.53:1) completed the study as per protocol. Fourteen percent patients recovered completely, 76.7% patients had a residual patch at the end. Number of lesions reduced significantly 2nd follow-up onwards while the lesional size showed significant decrease 1st follow-up onward. Nerve palpability also reduced significantly at treatment completion. Histological improvement was appreciable; lymphocytic infiltration reduced significantly 2nd follow-up onward and presence of granuloma 1st FU onward. Only four patients complained of occasional, uneventful epigastric pain during the study. Conclusion: Although the frequency of persistence of lesions after completion of therapy was high, histological evidence of activity was present in a minority (7%). Thus, the standard WHO MDT-PB regimen was found to be effective, safe and well-tolerated
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