86,895 research outputs found
Dell'Ospitalità. L'essere per l'inizio di Nunzio Incardona
No full textThe author explores the work of Nunzio Incardona using the Derridean category of hospitality. The hermeneutic gain is an unprecedented reading of the beginning of philosophy that Incardona takes from Hegel
Introduzione. Il suono delle cose
No full textThis paper introduces the book of the theoretical texts by the composer Federico Incardona (Palermo, 1958-2006), collected and put in order by his students, now stored in the musicological library of Palermo University; it draws a concept map to guide the reader into Incardona’s labyrinthine path. The fundamental concepts, highlighted and analyzed, are: the “inaudito” (what you never heard) as the result of a research in which the composer is involved even physically; the “sign”, as a tool to objectify the unheard; the “tone row” as the order of notes obtained by their bonds with the sensations and experiences: the epiphany of the sound of things: the “tradition” as “permanent revolution”, a R. Kolisch’s idea that Incardona learned from H.-K. Metzger ; the “work” as an utopian aspiration
Predicting human-immunodeficiency virus rebound after therapy initiation/switch using genetic, laboratory, and clinical data
No full textOptimization of combination antiretroviral therapy (CART) for treatment of human immunodeficiency virus (HIV) infection usually targets achievement of suppression of plasma viral load at specific time points after therapy initiation (e.g. 12 or 24 weeks). In the majority of antiretroviral-naïve patients, modern CARTs are usually powerful enough to push the HIV-RNA load down to undetectable levels using standard detection assays (i.e. 50 copies/mL). However, emergence of drug resistance and viral load rebound is still a concern, especially in patients who failed multiple lines of therapy. Nowadays, understanding and predicting CART durability, i.e. how long an antiretroviral therapy can be sustained without changes, in absence of viral load rebound or other adverse events, has become an important challenge to address. In this work, we develop and implement a model to predict CART durability using multiple input domains (demographics, clinical, laboratory, and virus genetics), with data extracted from one of the largest HIV cohorts worldwide, the EuResist integrated database
OBSERVING THE POLARIZED COSMIC MICROWAVE BACKGROUND FROM THE EARTH: SCANNING STRATEGY AND POLARIMETERS TEST FOR THE LSPE/STRIP INSTRUMENT
No full textDetecting B-mode polarization anisotropies on large angular scales in the Cosmic Microwave Background (CMB) polarization pattern is one of the major challenges in modern observational cosmology since it would give us an important evidence in favor of the inflationary paradigm and would shed light on the physics of the very early Universe. Multi-frequency observations are required to disentangle the very weak CMB signal from diffuse polarized foregrounds originating by radiative processes in our galaxy. The “Large Scale Polarization Explorer” (LSPE) is an experiment that aims to constrain the ratio between the amplitudes of tensor and scalar modes to r ≈ 0.03 and to study the polarized emission of the Milky Way. LSPE is composed of two instruments: SWIPE, a stratospheric balloon operating at 140, 210 and 240 GHz that will fly for two weeks in the Northern Hemisphere during the polar night of 2021, and STRIP, a ground-based telescope that will start to take data in early 2021 from the “Observatorio del Teide” in Tenerife observing the sky at 43 GHz (Q-band) and 95 GHz (W-band). In my thesis, I show the results of the unit-level tests campaign on the STRIP detectors that took place at “Università degli Studi di Milano Bicocca” from September 2017 to July 2018, and I present the code I developed and the simulations I performed to study the STRIP scanning strategy. During the unit-level tests, more than 800 tests on 68 polarimeters have been performed in order to select the 55 (49 Q-band and 6 W-band) with the best performance in terms of central frequencies, bandwidths, noise temperatures, white noise levels, slopes and knee frequencies. The STRIP scanning strategy is based on spinning the telescope around the azimuth axis with constant elevation in order to overlap the SWIPE coverage maintaining a sensitivity of 1.6 μK (on average) per sky pixels of 1°. Individual sources will be periodically observed both for calibration and study purposes
Stochastic Modelling of Genotypic Drug-Resistance for Human Immunodeficiency Virus towards Long-Term Combination Therapy Optimisation
No full textMOTIVATION: Several mathematical models have been investigated for the description of viral dynamics in the human body: HIV-1 infection is a particular and interesting scenario, because the virus attacks cells of the immune system that have a role in the antibody production and its high mutation rate permits to escape both the immune response and, in some cases, the drug pressure. The viral genetic evolution is intrinsically a stochastic process, eventually driven by the drug pressure, dependent on the drug combinations and concentration: in this article the viral genotypic drug resistance onset is the main focus addressed. The theoretical basis is the modelling of HIV-1 population dynamics as a predator-prey system of differential equations with a time-dependent therapy efficacy term, while the viral genome mutation evolution follows a Poisson distribution. The instant probabilities of drug resistance are estimated by means of functions trained from in vitro phenotypes, with a roulette-wheel-based mechanisms of resistant selection. Simulations have been designed for treatments made of one and two drugs as well as for combination antiretroviral therapies. The effect of limited adherence to therapy was also analyzed. Sequential treatment change episodes were also exploited with the aim to evaluate optimal synoptic treatment scenarios. RESULTS: The stochastic predator-prey modelling usefully predicted long-term virologic outcomes of evolved HIV-1 strains for selected antiretroviral therapy combinations. For a set of widely used combination therapies, results were consistent with findings reported in literature and with estimates coming from analysis on a large retrospective data base (EuResist)
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Pain Coping Strategies in Pediatric Patients with Acute Leukemias in the First Month of Therapy: Effects of Treatments and Implications on Procedural Analgesia
No full textChildren with leukemia experience difficulties adapting to medical procedures and to the chemotherapy’s adverse effects. Study’s objectives were to identify which coping strategies could be associated with the treatments’ factors and with the dosage of sedation analgesic drugs during bone marrow aspirates. A total of 125 patients (mean = 6.79 years; standard deviation = 3.40), majority with acute lymphoblastic leukemia (90.4%) and their parents received, one month after diagnosis, the Pediatric Pain Coping Inventory. Data on the severe treatment effects and on the dosage of drugs in sedation-analgesia were also collected. An ANCOVA model (R2 = 0.25) showed that, weighing the age factor (F = 3.47; df = 3; p = 0.02), the number of episodes of fever (F = 4.78; df = 1; p = 0.03), nausea (F = 4.71; df = 1; p = 0.03) and mucositis (F = 5.81; df = 1; p = 0.02) influenced the use of distraction. Cognitive self-instructions (R2 = 0.22) were influenced by the number of hospitalizations (F = 5.14; df = 1; p = 0.03) and mucositis (F = 8.48; df = 3; p = 0.004) and by child’s age (F = 3.76; df = 3; p = 0.01). Children who sought parental support more frequently (F = 9.7; df = 2; p = 0.0001) and who tended not to succumb to a catastrophic attitude (F = 13.33; df = 2; p = 0.001) during the induction treatment phase required lower drug dosages, especially propofol. The clinical application of these results could be to encourage the use of cognitive self-instructions and search for social support
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