7,211 research outputs found
Accounting for Impact at Imperial College London
No full textWe report findings of a study of academic engagement and commercialisation at Imperial College London. We detail the extent of collaboration with industry, consulting, patenting and entrepreneurship by Imperial academics, as well as individuals’ motivations and perceived barriers to engagement. The data stems from archival records held by the College, complemented by external databases, and a survey conducted among all academic staff in 2013
Black diamonds : coal, the Royal Navy, and British imperial coaling stations, circa 1870−1914
No full textThis thesis examines how the expansion of a steam-powered Royal Navy from the second half of the nineteenth century had wider ramifications across the British Empire. In particular, it considers how steam propulsion made vessels utterly dependent on a particular resource – coal – and its distribution around the world. In doing so, it shows that the ‘coal question’, almost totally ignored in previous histories, was central to questions of imperial and trade defence, required the creation of infrastructures that spanned the globe, and connected British sailors with a plethora of different imperial, maritime, and foreign peoples.
Although a limited number of studies have highlighted the importance of coal to imperial defence, this thesis considers the wider context of the period 1870−1914 in order to understand the significant place of coal in these discussions. In doing so, it shows coal’s place within wider changes to political ideologies, imperial defence schemes, popular imperialism and navalism, knowledge collection, and the growth of the state apparatus.
A robust coaling infrastructure was required to ensure quality naval coal was available globally on a huge geographical scale. This involved a large number of bodies, but this has never been examined by scholars for this period. Although naval coaling relied heavily on the coal export industry, the Admiralty had a key role in ensuring that the infrastructure, particularly after 1880, could cope with increases in ship size and number and competition from its rivals. The thesis also shows how these processes worked on the ground, from testing and purchasing coal to the methods and labour used to load in on warships.
The thesis also shows that the necessity of coaling in foreign stations fostered new interactions between naval personnel and the wider world. Although naval visits to these places are prime examples of British encounters beyond its own shores at the zenith of empire, these are largely absent from existing studies. Thus, it explores how the interactions with local populations, other maritime visitors, and the stations themselves shaped the experience of sailors abroad, and created a maritime community spanning large oceanic spaces
The SSC of the Generalised Jahangir’s Graph Jm,k and its Algebraic Characterizations
No full textIn this article, we present important combinatorial and algebraicproperties of spanning simplicial complex (SSC) of the generalised Jahangir’sgraph Jm,k. We describe the relation to find f−vectors associatedto Δs(Jm,k) and determine the Hilbert series for the SR-ring KΔs(Jm,k).In the end, we present the associated primes of the facet ideal IF(Δs(Jm,k))and the Cohen-Macaulay characterization of the SR-ring of Δs(Jm,k).AMS (MOS) Subject Classification Codes: Primary 13-P10, Secondary 13-F20, 13-C14, 13-H10.Corresponding Author: Agha KashifKey Words: Simplicial Complexes, f-vectors, Spanning Trees, Face Ring, Hilbert Series, CohenMacaulay
To <i>JM</i> on Its 75th Anniversary
No full text This article discusses how Journal of Marketing ( JM) has influenced marketing science and practice by publishing articles on substantive topics relevant to customers, managers, organizations, markets, and society. The journal's 75th anniversary coincides with the 50th anniversary of the Marketing Science Institute (MSI). Frequently, JM and MSI have collaborated to address important substantive marketing issues identified in MSI's Research Priorities. The author highlights seminal articles on brand equity; business-to-business marketing (including sales force management); connecting marketing information, metrics, and strategy; consumer behavior; innovation, new product development. and product management; marketing orientation and capabilities; and market research, methodology and services. She also draws attention to articles that have won the Sheth Foundation/ JM Award and the H. Paul Root Award. The article describes how JM‘s knowledge dissemination is amplified by powerful social network effects. Ideas in JM articles diffuse through the business community, influencing the mind-set of managers worldwide. </jats:p
Reduced cytochrome c: exploring its promoting function in synergistic denitrification by Pseudomonas sp. JM-7 and Thiobacillus denitrificans
No full textExcessive accumulation of nitrate in natural ecosystems can lead to eutrophication of water bodies, resulting in environmental impacts such as algal blooms and red tides that pose serious threats to environmental and human health. Autotrophic denitrification is a resource-efficient biological nitrogen removal technology, but the slow growth and low electron transfer efficiency of autotrophic denitrifiers limit their practical application. In this study, the heterotrophic denitrifying bacterium Pseudomonas sp. JM-7 (P. JM-7) was used in mixed culture with the autotrophic denitrifying Thiobacillus denitrificans ATCC 25259 to form a heterotrophic-autotrophic synergistic denitrification process (mixPT) to enhance electron transfer and improve the denitrification efficiency. Our results for an initial nitrate concentration of 430 mg/L showed that P. JM-7 reduced approximately 210 mg/L nitrate (48.8 %) in 90 h, with 1 g/L yeast extract powder (YEP) as the electron donor, while Thiobacillus denitrificans barely removed nitrate. In contrast, the mixPT system reduced approximately 360 mg/L nitrate (83.3 %), nearly 1.7 times greater than P. JM-7 alone. The mixPT culture also exhibited excellent denitrification in low carbon waters (10 mg/L), and removed 40 mg/L nitrate completely within 120 h. Cytochrome c produced by Pseudomonas sp. JM-7, which is an excellent electron transfer mediator for denitrification by Thiobacillus denitrificans, played a crucial role in the heterotrophic-autotrophic syntrophic denitrification. The adsorption effect of Pseudomonas sp. JM-7 shortened the contact distance between the autotrophic denitrifying bacteria and cytochrome c, which made it easy for cytochrome c to transfer the electrons to the autotrophic bacteria directly, thereby reducing the loss of electrons in the process of transfer, and improved the electron utilization efficiency. These findings have demonstrated the potential applications of mixPT system in controlling eutrophic waters and propose cytochrome c of Pseudomonas sp. JM-7 could serve as a novel and high-quality electron transfer mediator. Furthermore, this study have overcome the restriction of low denitrification efficiency exhibited by heterotrophic denitrifying bacteria Pseudomonas sp. JM-7 in low-carbon environments and expanded the utilisation of Pseudomonas sp. JM-7 in low carbon environments
JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species
No full text\ua9 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.Studies showed that JM-20, a benzodiazepine-dihydropyridine hybrid molecule, protects against rotenone and 6-hydroxydopamine neurotoxicity. However, its protective effects against cytotoxicity induced by endogenous neurotoxins involved in Parkinson’s disease (PD) pathogenesis have never been investigated. In this study, we evaluated the ability of JM-20 to inhibit alpha-synuclein (aSyn) aggregation. We also evaluated the interactions of JM-20 with aSyn by molecular docking and molecular dynamics and assessed the protective effect of JM-20 against aminochrome cytotoxicity. We demonstrated that JM-20 induced the formation of heterogeneous amyloid fibrils, which were innocuous to primary cultures of mesencephalic cells. Moreover, JM-20 reduced the average size of aSyn positive inclusions in H4 cells transfected with SynT wild-type and synphilin-1-V5, but not in HEK cells transfected with synphilin-1-GFP. In silico studies showed the interaction between JM-20 and the aSyn-binding site. Additionally, we showed that JM-20 protects SH-SY5Y cells against aminochrome cytotoxicity. These results reinforce the potential of JM-20 as a neuroprotective compound for PD and suggest aSyn as a molecular target for JM-20
Increasing Distributed Generation Penetration using Soft Normally-Open Points
No full textThis paper considers the effects of various voltage control solutions on facilitating an increase in allowable levels of distributed generation installation before voltage violations occur. In particular, the voltage control solution that is focused on is the implementation of `soft' normally-open points (SNOPs), a term which refers to power electronic devices installed in place of a normally-open point in a medium-voltage distribution network which allows for control of real and reactive power flows between each end point of its installation sites. While other benefits of SNOP installation are discussed, the intent of this paper is to determine whether SNOPs are a viable alternative to other voltage control strategies for this particular application. As such, the SNOPs ability to affect the voltage profile along feeders within a distribution system is focused on with other voltage control options used for comparative purposes. Results from studies on multiple network models with varying topologies are presented and a case study which considers economic benefits of increasing feasible DG penetration is also given
Promoting denitrification via high electron conversion ratio in the iron valence cycle: prospects for Pseudomonas sp. JM-7 application in environmental engineering
No full textThe interdependence between iron and nitrogen in the environment is of utmost importance, and this study has explored the intricate relationship between denitrification and iron valence cycling using Pseudomonas sp. strain JM-7 (P. JM-7) as a model bacteria. Our research demonstrated that P. JM-7 had the ability to effectuate electron transfer from the periplasmic space to electron acceptors, such as nitrate, via Cytochrome c-proteins (c-Cyts). We found that iron valence state transformations with Fe(II)/Fe(III) promoted P. JM-7′s denitrification of nitrate coupled to yeast extract powder (YEP) oxidation. Denitrification rates depended on temperature (>21 °C) and pH (6–9). During logarithmic growth, 5 g/L YEP enabled 350 mg/L nitrate removal, increasing to 1650 mg/L in stable growth. Addition of 4 mM Fe(II)/Fe(III) increased denitrification to 500 mg/L during logarithmic growth. The dynamic test results displayed that compared to the SiO2 filler control group, iron-containing fillers could facilitate P. JM-7 to reduce 100 mg/L nitrate with 50 mg/L YEP electrons, corresponding to 6 times the maximum electron transfer efficiency in the static test. Overall, iron redox cycling significantly enhanced P. JM-7 denitrification, imparting insights into iron–nitrogen interactions. In summary, our research imparts valuable insights into the nexus between iron and nitrogen in the environment, highlighting the potential application of P. JM-7 in environmental engineering. Our findings indicate that P. JM-7 exhibits a significant denitrification capability, and further research is recommended to investigate its ability to remove phosphorus and promote sustainable environmental remediation practices
Desempenho de macieiras 'Imperial Gala' e 'Mishima Fuji' em diferentes porta-enxertos.
No full textO objetivo deste trabalho foi avaliar a influência de diferentes porta?enxertos no desempenho das cultivares de macieira ( Malus domestica ) Imperial Gala e Mishima Fuji. O delineamento experimental utilizado foi o de blocos ao acaso, com quatro repetições. Utilizaram?se os porta?enxertos CG.969, CG.874, CG.210, CG.56, CG.008, JM.2 e JM.7, além da combinação de Marubakaido com interenxerto de M.9 (Marubakaido/M.9). Avaliaram-se as variáveis: produção por planta, produtividade, número de frutos por planta, massa de fruto, área da seção transversal do tronco, sólidos solúveis, firmeza do fruto e índice iodo?amido. A produtividade de ambas as cultivares foi maior com os porta?enxertos Marubakaido/M.9, JM.2, CG.008, CG.874, CG.210 e CG.56. Além disso, os porta?enxertos CG.008, CG.874, CG.210 e CG.56 reduzem o vigor da cultivar?copa, mas sem reduzir a produtividade. O teor de sólidos solúveis dos frutos é maior quando se utilizam porta?enxertos menos vigorosos.Título em inglês: Performance of 'Imperial Gala' and 'Mishima Fuji' apples on different rootstocks
Uterine transplantation: a promising surrogate to surrogacy?
No full textUterine transplantation: a promising surrogate to surrogacy?
Grynberg M1, Ayoubi JM, Bulletti C, Frydman R, Fanchin R.
Author information
Abstract
Infertility due to the inability of the uterus to carry a pregnancy ranks among the most unresolved issues in reproductive medicine. It affects millions of women worldwide who have congenital or acquired uterine affections, often requiring hysterectomy, and potentially represents a considerable fraction of the general infertile population. Patients suffering from severe uterine infertility are currently compelled to go through gestational surrogacy or adoption; both approaches, unfortunately, deprive them of the maternal experience of pregnancy and birth. Uterine transplantation represents an outstanding, yet complex, perspective to alleviating definitive uterine infertility. In the past decades, a number of scientific experiments conducted both in animals and women, focusing on uterine transplantation, have led to promising results. Collectively, these findings undoubtedly constitute a sound basis to clinically apply uterine transplantation in the near future. This paper is, however, an overview not only of the extent and limitations of accumulated scientific knowledge on uterine transplantation, but also its ethical implications, in an effort to define the actual place of such an approach among the therapeutic arsenal for alleviating infertility.
© 2011 New York Academy of Sciences
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