86,535 research outputs found
L'impiego dei farmaci antidepressivi nel puerperio
No full textRiassunto. Il puerperio, così come la gravidanza, è associato ad un maggior rischio di
disturbi d’ansia e/o disturbi depressivi. La depressione post-partum (DPP), frequentemente
in comorbilità con sintomi d’ansia, è il disturbo che si manifesta più frequentemente
dopo il parto, con tassi di prevalenza compresi tra il 5 e il 15%. Tra gli antidepressivi
(AD), gli inibitori selettivi della ricaptazione della serotonina (SSRI) sono considerati
farmaci di prima scelta nel trattamento dei disturbi depressivi puerperali e in
particolare della DPP. È quindi fondamentale stabilire, per quelle madri che necessitino
di un trattamento con SSRI, il profilo di sicurezza di questi farmaci durante l’allattamento.
I vantaggi dell’allattamento al seno, sia per la madre che per il bambino, sono
infatti ben documentati. Se, da un lato, tutti gli AD, compresi gli SSRI, passano nel latte,
è comunque vero che il rapporto tra concentrazioni ematiche del farmaco e concentrazioni
nel latte, proposto per valutare il rischio di una determinata molecola durante
l’allattamento, appare un parametro che non è in grado di predire in modo accurato la
sicurezza di questi farmaci. Da un’analisi delle evidenze presenti nella letteratura si può
concludere che, tra gli SSRI, paroxetina e sertralina offrono il miglior profilo di sicurezza,
non essendo fino ad oggi stati segnalati effetti collaterali per il neonato in corso di allattamento
con tali AD. Nonostante questi risultati rassicuranti, appaiono comunque necessari
ulteriori studi che permettano di definire meglio il profilo di sicurezza. Come regola
generale, è importante monitorare con molta attenzione le condizioni di un neonato
la cui madre assuma un AD in corso di allattamento, in modo da poter riconoscere precocemente
eventuali effetti collaterali farmaco-indotti.
Parole chiave. Depressione post-partum, allattamento, antidepressivi, inibitori selettivi
della ricaptazione della serotonina, tossicità neonatale
Transcriptome-wide selection and validation of a solid set of reference genes for gene expression studies in the cephalopod mollusk Octopus vulgaris
No full textOctopus vulgaris is a cephalopod mollusk and an active marine predator that has been at the center of a number of studies focused on the understanding of neural and biological plasticity. Studies on the machinery involved in e.g., learning and memory, regeneration, and neuromodulation are required to shed light on the conserved and/or unique mechanisms that these animals have evolved. Analysis of gene expression is one of the most essential means to expand our understanding of biological machinery, and the selection of an appropriate set of reference genes is the prerequisite for the quantitative real-time polymerase chain reaction (qRT-PCR). Here we selected 77 candidate reference genes (RGs) from a pool of stable and relatively high-expressed transcripts identified from the full-length transcriptome of O. vulgaris, and we evaluated their expression stabilities in different tissues through geNorm, NormFinder, Bestkeeper, Delta-CT method, and RefFinder. Although various algorithms provided different assemblages of the most stable reference genes for the different kinds of tissues tested here, a comprehensive ranking revealed RGs specific to the nervous system (Ov-RNF7 and Ov-RIOK2) and Ov-EIF2A and Ov-CUL1 across all considered tissues. Furthermore, we validated RGs by assessing the expression profiles of nine target genes (Ov-Naa15, Ov-Ltv1, Ov-CG9286, Ov-EIF3M, Ov-NOB1, Ov-CSDE1, Ov-Abi2, Ov-Homer2, and Ov-Snx20) in different areas of the octopus nervous system (gastric ganglion, as control). Our study allowed us to identify the most extensive set of stable reference genes currently available for the nervous system and appendages of adult O. vulgaris
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Orazione funebre & componimenti diversi per la morte dell'augustissimo imperadore de' romani Francesco I., granduca VIII. di Toscana : celebrati dalla nazione ebrea di Livorno.
No full textEngraved title vignette; head- and tail-pieces.Signatures: pi1 *² A-F² a-d².Funeral oration in Spanish by Abraham Isaac Castello and in Italian translation by Joseph Castello.Mode of access: Internet.Bound in decorated paper wrappers
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
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