3,124 research outputs found
Antibody therapy of lymphoma
No full textThe availability of rituximab and the possible imminent availability of two new radiolabelled monoclonal anti-CD20 antibodies (Yttrium-90 (90Y)-ibritumomab and Iodine-131(131I)-tositumomab) have captured much attention in the treatment of lymphoma. The chimeric monoclonal anti-CD20 antibody, rituximab has truly heralded a new era for the treatment of lymphoma and human malignancies. The full potential of antibody-based therapy to improve the outcome in patients with B-cell non-Hodgkin’s lymphoma has yet to be defined, but recent data suggests that the combination of chemotherapy plus rituximab may significantly improve outcome for patients with aggressive lymphoma over chemotherapy alone. Highly promising data are also emerging for the use of rituximab in combination with chemotherapy in other types of lymphoma. New advances in antibody therapy, driven by new technologies and defining novel antigen targets, offer the promise of more effective tumour specific therapies. Combinations of antibodies, either conjugated with radioisotopes or unlabelled, used with chemotherapy are likely to provide definitive advances in the treatment of lymphoma in the immediate future
Synthesis optimization and charge carrier transfer mechanism in LiLuSiO<sub>4</sub>:Ce, Tm storage phosphor
No full textLiLuSiO4:Ce and LiLuSiO4:Ce, Tm show very efficient charge carrier storage properties upon beta irradiation after samples have received treatment in vacuum. They outperform the commercial storage phosphor BaFBr(I):Eu2+ in many aspects. The influence of the synthesis conditions, Ce and Tm concentration, nonstoichiometry and codoping with Ca, Hf, Al and Ge are reported. Based on the results of the synthesis optimization, thermoluminescence (TL) emission and TL excitation spectra a mechanism of charge carrier transfer, storage, and recombination during irradiation and thermal or optical readout is proposed.Accepted Author ManuscriptRST/Fundamental Aspects of Materials and EnergyRST/Luminescence Material
GA Landsat 5 TM Analysis Ready Data Collection 3
No full textMaintenance and Update Frequency: asNeededStatement: This product is derived from the USGS Landsat Collection 1 archive.
The Moderate Resolution Imaging Spectroradiometer (MODIS) MCD43A1 Version 6 Bidirectional Reflectance Distribution Function and Albedo (BRDF/Albedo) Model Parameters dataset was provided by the National Aeronautics and Space Administration (NASA). It was produced daily using 16 days of Terra and Aqua MODIS data at 500 m resolution.
The ozone data was provided by Environment Canada.
The Aerosol Optical Thickness data was provided by the Commonwealth Scientific and Industrial Research Organisation (CSIRO).
The Precipitable Water for Entire Atmosphere data was provided by the National Oceanic and Atmospheric Administration (NOAA) / Earth System Research Laboratory (ESRL) / Physical Sciences Division (PSD).
The baseline Digital Surface Model (DSM) data produced from the Shuttle Radar Topography Mission (SRTM) was provided by the National Geospatial-Intelligence Agency (NGA).
Level 1 Collection 1 data was provided by the United States Geological Survey (USGS)'s Earth Resources Observation and Science (EROS) Center.<b>BACKGROUND</b><br/><p><br/><p>The United States Geological Survey's (USGS) Landsat satellite program has been capturing images of the Australian continent for more than 30 years. This data is highly useful for land and coastal mapping studies. <br/><p>In particular, the light reflected from the Earth’s surface (surface reflectance) is important for monitoring environmental resources – such as agricultural production and mining activities – over time. <br/><p>We need to make accurate comparisons of imagery acquired at different times, seasons and geographic locations. However, inconsistencies can arise due to variations in atmospheric conditions, sun position, sensor view angle, surface slope and surface aspect. These need to be reduced or removed to ensure the data is consistent and can be compared over time. <br/><p> </p><br/><b>WHAT THIS PRODUCT OFFERS</b><br/><p><br/><p>GA Landsat 5 TM Analysis Ready Data Collection 3 takes Landsat 5 Thematic Mapper (TM) imagery captured over the Australian continent and corrects for inconsistencies across land and coastal fringes. The result is accurate and standardised surface reflectance data, which is instrumental in identifying and quantifying environmental change. <br/><p><br/><p>The TM instrument is an advanced, multispectral scanning, Earth resources sensor which is designed to categorise the Earth's surface. It is particularly useful for agricultural applications and identification of land use. <br/><p><br/><p>This product is a single, cohesive Analysis Ready Data (ARD) package, which allows you to analyse surface reflectance data as is, without the need to apply additional corrections. <br/><p><br/><p>It contains three sub-products that provide corrections or attribution information:<br/><p><br/><p> 1) GA Landsat 5 TM NBAR Collection 3 <br/><p> 2) GA Landsat 5 TM NBART Collection 3<br/><p> 3) GA Landsat 5 TM OA Collection 3<br/><p><br/><p>The resolution is a 30 m grid based on the USGS Landsat Collection 1 archive
Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks
No full textp53 mutant tumour cells respond to genotoxic insults by bypassing G1 arrest and halting in G2. Following release from G2 arrest they undergo mitotic catastrophe, whereby mitotic cycling is suppressed, delayed apoptosis begins and endopolyploid cells are produced. The ability of these endopolyploid cells to participate in the restitution process is controversial. To facilitate recovery, these endopolyploid cells must repair the extensive DNA damage induced. DNA damage and its resolution were studied by observing the kinetics of {gamma}-H2AX foci formation and by comet assay analysis. Subsequently, the kinetics and distribution of Rad51 foci were studied as a measure of homologous recombination. Here we present evidence of the resolution of DNA damage in endopolyploid cells through a decrease of tail moment by comet assay and in the number of cells expressing {gamma}-H2AX foci. Rad51 foci expression reached a maximum in endopolyploid cells on days 5-6 after irradiation, when delayed apoptosis was maximal, indicating that cells were being selected for survival at this time. Furthermore, the proportion of Annexin-V-positive polyploid cells decreased as they continued ongoing rounds of DNA replication, suggesting endoreduplication is involved in selecting cells resistant to apoptosis. Our findings suggest that after severe genotoxic insult endopolyploid cells have a transient survival advantage that may contribute to radioresistance of tumours that undergo mitotic catastrophe
The dependence of light extraction improvement on optimized surface microstructure for AlGaN-based UVC-LEDs considering TM-polarized emission
No full textIn order to improve the light extraction of AlGaN-based short wavelength ultraviolet light emitting diodes (DUC-LEDs), a type of microstructure with high aspect ratio is introduced and optimized on the AlN substrate surface. And, particle swarm optimization (PSO) algorithm is used to inverse design of the surface microstructure to maximize the light extraction efficiency (LEE). Considering that the propagation characteristics of TM-polarized light are different from that of TE-polarized light, the optical field distribution and LEE is analyzed for the UVC-LEDs with different TE-polarized component when the optimized surface microstructure is applied. Furthermore, the preparation process tolerance of the high aspect ratio structure is discussed by calculating the LED's LEE when the structural deviation occurs or morphology changes. Simulation results show that, by using the optimized surface microstructure based on parabola cone array, the LEDs' LEE is increased from 4.4% to 8.7% and from 0.4% to 3.7% for TE-polarized and TM-polarized emission, respectively. In addition, it is demonstrated that the light extraction improvement by the surface microstructure has a good tolerance to the structural deviation and morphology. The results are significant for improving light extraction and realizing high efficient short wavelength AlGaN-based UVC-LEDs by designing surface microstructures.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.ImPhys/Esmaeil Zadeh grou
Rigor and relevance in empirical TM research: Key issues and challenges Author links open overlay panel
No full textThis paper aims to offer a critical reflection on the way Talent Management (TM) is investigated in practice, by addressing the key issues regarding the quality (in terms of rigor and relevance) of academic empirical TM research and therefore the critical scrutiny of TM scholars’ work. We will argue that despite the growth in the quantity, the quality of many empirical TM papers is lagging behind and hindering the progress of the academic field of TM. Based on a content analysis of 174 peer-reviewed articles published between 2006 and 2017, the paper outlines nine critical issues regarding the quality of the existent empirical TM research. In order to improve the positioning of the field as well as the impact of TM research on practice itis absolutely necessary for TM scholars to secure the quality of academic empirical TM research. Also, the collaboration between practitioners and scholars should increase.Peer ReviewedPostprint (author's final draft
Rigor and relevance in empirical TM research: Key issues and challenges Author links open overlay panel
No full textThis paper aims to offer a critical reflection on the way Talent Management (TM) is investigated in practice, by addressing the key issues regarding the quality (in terms of rigor and relevance) of academic empirical TM research and therefore the critical scrutiny of TM scholars’ work. We will argue that despite the growth in the quantity, the quality of many empirical TM papers is lagging behind and hindering the progress of the academic field of TM. Based on a content analysis of 174 peer-reviewed articles published between 2006 and 2017, the paper outlines nine critical issues regarding the quality of the existent empirical TM research. In order to improve the positioning of the field as well as the impact of TM research on practice itis absolutely necessary for TM scholars to secure the quality of academic empirical TM research. Also, the collaboration between practitioners and scholars should increase.Peer Reviewe
Dalla Biblioteca Comunale di Urbania: due raccolte musicali per un interprete
No full textIn the Library of Urbania (Marche, Italy) six musical manuscripts containing seventeenth century arias and cantatas are preserved. They belonged to an aristocratic family of Apecchio, (Marche), the Ubaldini. This article investigates two of them containing cantatas by Cossoni, Giovanni Bonaventura Viviani, Legrenzi Bassani and others, and in which there is the note “ex libris Antonij Barbarini”. This article reconstructs the origin of these two manuscripts, for whom the author individuated the probable owner, the singer Ippolito Fusai, by means the repertory identified in it. A thorough investigation of this hitherto little-known manuscripts may shed new light on the diffusion and transmission of music in Italy during the Seventeenth and early-Eighteenth centurie
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
No full textRituximab, a monoclonal antibody which targets CD20 on B-cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 mAb are continually being sought. Here we demonstrate that type II (tositumomab-like) anti-CD20 mAb are 5 times more potent than type I (rituximab-like) reagents in depleting human CD20 Tg B-cells, despite both operating exclusively via activatory FcR-expressing macrophages. Much of this disparity in performance is attributable to type I mAb-mediated internalization of CD20 by B-cells leading to reduced macrophage recruitment and the degradation of CD20:mAb complexes, shortening mAb half-life. Importantly, human B cells from healthy donors, and most cases of Chronic Lymphatic Leukemia (CLL) and Mantle Cell Lymphoma, showed rapid CD20 internalization which paralleled that seen in the Tg mouse B cells, while most Follicular Lymphoma (FL) and Diffuse Large B-Cell Lymphoma (DLBCL) cells were far more resistant to CD20 loss. We postulate that differences in CD20 modulation may play a central role in determining the relative efficacy of rituximab in treating these diseases and strengthen the case for focusing on type II anti-CD20 mAb in the clinic. <br/
Antibody therapy of lymphoma.
No full textThe availability of rituximab and the possible imminent availability of two new radiolabelled monoclonal anti-CD20 antibodies (Yttrium-90 (90Y)-ibritumomab and Iodine-131(131I)-tositumomab) have captured much attention in the treatment of lymphoma. The chimeric monoclonal anti-CD20 antibody, rituximab has truly heralded a new era for the treatment of lymphoma and human malignancies. The full potential of antibody-based therapy to improve the outcome in patients with B-cell non-Hodgkin's lymphoma has yet to be defined, but recent data suggests that the combination of chemotherapy plus rituximab may significantly improve outcome for patients with aggressive lymphoma over chemotherapy alone. Highly promising data are also emerging for the use of rituximab in combination with chemotherapy in other types of lymphoma. New advances in antibody therapy, driven by new technologies and defining novel antigen targets, offer the promise of more effective tumour specific therapies. Combinations of antibodies, either conjugated with radioisotopes or unlabelled, used with chemotherapy are likely to provide definitive advances in the treatment of lymphoma in the immediate future
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