36 research outputs found
Pomen Petrovaradina u Ekthesis chronike iz XVI veka
No full textEkthesis chronike is a XVI century work written by an anonymous author. This author or compiler gives some data on our regions as well. The topic of this work is the part of the chronicle which relates to the Ottoman conquest of Hungary, especially to the mention of Petrovaradin, i. e. its’ siege and conquest by the Turks in 1526. The data provided by Ekthesis chronike is analyzed and compared with other contemporary sources, especially Turkish and Hungarian. Even though it is written in a popular manner and contains some mistakes, this chronicle is a very interesting source for late Byzantine history, but also for the period after the fall of Constantinople and Ottoman conquests during the XVI century
Addressing the challenges of Cloud Computing adoption in an enterprise environment: Use case for encouragement and raising awareness among the staff, development of secure and compliant components and analysis of application performance on different Microsoft Azure Cloud Services within the Cloud Competence Center in Rabobank
No full textRabobank is currently planning a complete transition of its services to the publiccloud. Currently there are around 400 DevOps teams that need to make thetransition from deployment on traditional on-premise infrastructure, to deploying their products to the public cloud. The thesis project investigates what are some of the biggest challenges in adopting cloud computing technologies in an enterprise.Some of these are encouraging the staff to adopt the technology, how toembed security and compliance to the cloud computing infrastructure and whichservices to choose when migrating an on-premise application to Microsoft Azure Cloud. Investigation has been done on how to better encourage and inform the staff about the cloud adoption. This is achieved by improving the Cloud Awareness session (where the employees are informed for the cloud initiatives in the bank) through implementation of complete CI/CD (Continuous Integration / Continuous Deployment) pipeline of a .NET Core 2.0 application with modern HTML5 responsive layout that deploys the web application on Microsoft Azure Public Cloud and gives recommendations for testing and monitoring. Moreover, the project investigates what is needed to develop the secure and compliant feature in a huge enterprise like Rabobank with an example of development an Azure Cosmos DB feature delivered as a VSTS (Visual Studio Team Services) extension to be used by the DevOps teams in their CI/CD pipeline. Finally, an analysis is done on the performance, cost and lifecycle management of the same .NET Core 2.0 application deployed on different service offerings by Microsoft Azure Public Cloud, including Windows Server virtual machine, Azure Web App Service and Azure Kubernetes Service.Computer Scienc
The Greek charter of the Hungarian King Stephen I
No full textThe first Hungarian Christian ruler, King Stephen I (997-1038) issued several
charters that have survived to this day. One of them is the charter issued
on behalf of the nuns from the Monastery of the Holy Theotokos in
Veszprémvölgy. The charter was written in the Greek language, and has been
the subject of many studies. The original has not been preserved; what
remains is a copy from the time of King Coloman, dated to 1109. The charter
has not been published in a critical edition in any language other than
Hungarian and even though it has been examined by numerous Hungarian
scholars, many questions remain open. The aim of the author is to provide a
critical edition and an English translation of the charter, but also to
clarify some remaining doubts about the charter and its contents.
Furthermore, some comparisons will be made with the Byzantine charters
issued at the beginning of the 11th and during the 12th century
Concurrent radiochemotherapy in advanced hypopharyngeal cancer
No full textAbstract Background Concurrent platinum-based radiochemotherapy has been recommended as a standard of care in patients with locally advanced squamous cell head and neck carcinomas. Unfortunately, there is a lack of level one evidence on best treatment approach for advanced hypopharyngeal cancer. This report aims to summarize the results of our study on concurrent radiochemotherapy in patients with advanced hypopharyngeal cancer. Methods A retrospective analysis of 41 patients with stage III-IV hypopharyngeal cancer was performed. All patients were treated with three dimensional conformal radiotherapy and received 70 Gy in 35 fractions (2 Gy per fraction, 5 fractions per week). In dependence of the period when radiotherapy was realized, two different treatment techniques were used. Concurrent chemotherapy consisted of cisplatin 30 mg/m2 given on a weekly basis. Results The median age was 52 years (range 29-70). Stage IV disease was recognized in 73.2% of the patients. Complete response rates at the primary site and at the metastatic neck lymph nodes were 68.3% and 36.6%, respectively. A complete composite response was present in 27 patients (65.9%). Median follow-up was 13 months (range 7-36). Distant metastases as initial failure occurred in 7 patients (46.7%). The 2-year local relapse-free survival and regional relapse-free survival rates were 55.2% and 75.8%, respectively. The 2-year locoregional relapse-free survival rate was 51.3%. The 2-year disease-free survival and overall survival rates were 29.3% and 32.8%, respectively. Confluent mucositis was developed in 46.3% of patients. Leucopenia grade 1 was the most frequent hematological toxicity. The median weight loss at the end of treatment was 12% (range 5-21). The worst grade of late toxicity was most commonly pronounced in the skin and in the subcutaneous tissue. Conclusions Based on unsatisfactory results in our study we suggest that the use of sequential radiochemotherapy or chemotherapy given concomitantly with altered fractionation radiotherapy with the implementation of intensity-modulated radiotherapy as radiotherapy technique could represent treatment approaches able to improve outcome in patients with advanced hypopharyngeal cancer.</p
Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors
No full textAbstract Background Concurrent radiochemotherapy is a recommended treatment option for patients with locally advanced squamous cell head and neck carcinomas with recent data showing the most significant absolute overall and event-free survival benefit achieved in patients with oropharyngeal tumours. The aim of this study was to analyse the results of three-dimensional conformal radiotherapy given with concomitant weekly cisplatin in patients with advanced oropharyngeal carcinoma and to identify prognostic factors influencing outcomes of this patients category. Methods Sixty-five patients with stage III or IV squamous cell carcinoma of the oropharynx who underwent concurrent radiochemotherapy between January 2005 and December 2010 were retrospectively analyzed. All patients received radiotherapy to 70 Gy/35 fractions/2 Gy per fraction/5 fractions per week. Concurrent chemotherapy consisted of weekly cisplatin (30 mg/m2) started at the first day of radiotherapy. Results Median age was 57 years (range, 36 to 69 years) and 59 (90.8%) patients were male. Complete composite response was achieved in 47 patients (72.3%). Local and/or regional recurrence was the most frequent treatment failure present in 19 out of 25 patients (76.0%). At a median follow-up of 14 months (range, 5 to 72 months), 2-year local relapse-free, regional relapse-free, locoregional relapse-free, disease-free, and overall survival rates were 48.8%, 57.8%, 41.7%, 33.2% and 49.7%, respectively. On multivariate analysis the only significant factor for inferior regional relapse-free survival was the advanced N stage (p = 0.048). Higher overall stage was independent prognostic factor for poorer local relapse-free survival, locoregional relapse-free survival and disease-free survival (p = 0.022, p = 0.003 and p = 0.003, respectively). Pre-treatment haemoglobin concentration was an independent prognostic factor for local relapse-free survival, regional relapse-free survival, locoregional relapse-free survival, disease-free survival, and overall survival (p = 0.002, p = 0.021, p = 0.001, p = 0.002 and p = 0.002, respectively). Conclusions Poor treatments results of this study suggested that introduction of intensity-modulated radiotherapy, use of induction chemotherapy followed by concurrent radiochemotherapy, accelerated radiotherapy regimens, and molecular targeted therapies could positively influence treatment outcomes. The incorporation of reversal of anaemia should be also expected to provide further improvement in locoregional control and survival in patients with advanced squamous cell carcinoma of the oropharynx.</p
Impact on radiation dose and volume V57 Gy of the brain on recurrence and survival of patients with glioblastoma multiformae
No full textThe aim of the study was to analyze impact of irradiated brain volume V57 Gy (volume receiving 57 Gy and more) on time to progression and survival of patients with glioblastoma
Impact on radiation dose and volume V57 Gy of the brain on recurrence and survival of patients with glioblastoma multiformae
No full textAbstractBackgroundThe aim of the study was to analyze impact of irradiated brain volume V57 Gy (volume receiving 57 Gy and more) on time to progression and survival of patients with glioblastoma.Patients and methodsDosimetric analysis of treatment plan data has been performed on 70 patients with glioblastoma, treated with postoperative radiochemotherapy with temozolomide, followed by adjuvant temozolomide. Patients were treated with 2 different methods of definition of treatment volumes and prescription of radiation dose. First group of patients has been treated with one treatment volume receiving 60 Gy in 2 Gy daily fraction (31 patients) and second group of the patients has been treated with “cone-down” technique, which consisted of two phases of treatment: the first phase of 46 Gy in 2 Gy fraction followed by “cone-down” boost of 14 Gy in 2 Gy fraction (39 patients). Quantification of V57 Gy and ratio brain volume/V57Gy has been done. Average values of both parameters have been taken as a threshold value and patients have been split into 2 groups for each parameter (values smaller/ lager than threshold value).ResultsMean value for V57 Gy was 593.39 cm3(range 166.94 to 968.60 cm3), mean value of brain volume has was 1332.86 cm3(range 1047.00 to 1671.90 cm3) and mean value of brain-to-V57Gy ratio was 2.46 (range 1.42 to 7.67). There was no significant difference between two groups for both V57 Gy and ratio between brain volume and V57 Gy.ConclusionsIrradiated volume with dose 57 Gy or more (V57 Gy) and ration between whole brain volume and 57 Gy had no impact on time to progression and survival of patients with glioblastoma.</jats:sec
Why are features deprecated?: An investigation into the motivation behind deprecation
No full textIn this study, we investigate why API producers deprecate features. Previous work has shown us that knowing the rationale behind deprecation of an API aids a consumer in deciding to react, thus hinting at a diversity of deprecation reasons. We manually analyze the Javadoc of 374 deprecated methods pertaining four mainstream Java APIs to see whether the reason behind deprecation is mentioned. We find that understanding the rationale from just the Javadoc is insufficient; hence we add other data sources such as the source code, issue tracker data and commit history. We observe 12 reasons that trigger API producers to deprecate a feature. We evaluate an automated approach to classify these motivations.Accepted author manuscriptSoftware Engineerin
Concurrent Paclitaxel and Radiotherapy Lung Cancer as a Model for Successful Implementation
No full textHead and neck cancer in young adults treated with 3-D conformal radiotherapy
No full textBackground: Purpose of this study was to determine patterns of failure in young adults with head and neck cancer treated with 3-D conformal radiotherapy. Methods: Twenty-eight patients with head and neck cancer younger than 41 years of age were treated with 3-D conformal radiotherapy. Patients’ median age was 31.4 years. Radiotherapy was delivered in the median total dose of 67.2 Gy to PTV (range, 60.0-70.0 Gy) with or without concurrent cisplatin. Results: The median duration of follow-up was 20 months. Distant metastases were the most frequent pattern of failure. The locoregional relapse-free survival (LRR-FS) rate at 2 years was 66.6%. The median duration of LRR-FS was 15 months. The distant metastases relapse-free survival (DMR-FS) rate at 2 years was 65.7%. The median duration of DMR-FS was also 15 months. The overall survival (OS) rate at 2 years was 57.2%. The median duration of OS was 20 months. Conclusion: Radiotherapy with or without concurrent chemotherapy plays an important role in treatment of patients with head and neck cancer. Recent developments of new radiotherapy techniques have increased rates of local control. Distant metastases remain the most frequent pattern of failure in this group of young adults with head and neck cancer. Introducing new cytotoxic and target therapies in future could lead to better outcome in this subgroup of patients
