1,778,858 research outputs found
IgA in the horse: cloning of equine polymeric Ig receptor and J chain and characterization of recombinant forms of equine IgA
Get PDFAs in other mammals, immunoglobulin A (IgA) in the horse has a key role in immune defense. To better dissect equine IgA function, we isolated complementary DNA (cDNA) clones for equine J chain and polymeric Ig receptor (pIgR). When coexpressed with equine IgA, equine J chain promoted efficient IgA polymerization. A truncated version of equine pIgR, equivalent to secretory component, bound with nanomolar affinity to recombinant equine and human dimeric IgA but not with monomeric IgA from either species. Searches of the equine genome localized equine J chain and pIgR to chromosomes 3 and 5, respectively, with J chain and pIgR coding sequence distributed across 4 and 11 exons, respectively. Comparisons of transcriptional regulatory sequences suggest that horse and human pIgR expression is controlled through common regulatory mechanisms that are less conserved in rodents. These studies pave the way for full dissection of equine IgA function and open up possibilities for immune-based treatment of equine diseases
IGA Nephropathy : From Molecules to Men /
No full textThe author of this volume has studied IgA nephropathy for nearly 25 years, almost as long as primary IgA nephropathy has been recognized as a new disease. IgA nephropathy, considered to be an immune-complex-mediated glomerulonephri tis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing pro- liferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. Since the pathogenesis of IgA nephropathy is still obscure, specific treatment is not yet available. Previous approaches have included tonsillectomy, anticoagulants, prednisolone, immunosuppressants, angiotensin-converting enzyme inhibitors and others. During his career, the author of this book has studied many aspects of IgA nephropathy, shedding much light on the mechanism of development and progression of this disease. He also undertook new treatments for patients and developed animal models for IgA nephropathy. The purpose of the present volume is to review the authors work on pathogenesis and treatment of the disease and to provide the most up-to-date findings on this subject, constituting a valuable source of information for nephrologists, general practitioners, residents and interns.The author of this volume has studied IgA nephropathy for nearly 25 years, almost as long as primary IgA nephropathy has been recognized as a new disease. IgA nephropathy, considered to be an immune-complex-mediated glomerulonephri tis, is characterized by granular deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and is defined as nephropathy showing pro- liferative changes in the glomerular mesangial cells and increases in the mesangial matrices. Apart from being one of the most common types of chronic glomerulonephritis, it is also the most frequent case of end-stage renal disease. Since the pathogenesis of IgA nephropathy is still obscure, specific treatment is not yet available. Previous approaches have included tonsillectomy, anticoagulants, prednisolone, immunosuppressants, angiotensin-converting enzyme inhibitors and others. During his career, the author of this book has studied many aspects of IgA nephropathy, shedding much light on the mechanism of development and progression of this disease. He also undertook new treatments for patients and developed animal models for IgA nephropathy. The purpose of the present volume is to review the authors work on pathogenesis and treatment of the disease and to provide the most up-to-date findings on this subject, constituting a valuable source of information for nephrologists, general practitioners, residents and interns.Print version recor
Selective measurement of anti-tTG antibodies in coeliac disease and IgA deficiency : an alternative pathway
Get PDFObjective
To determine the ability of selective antibody testing to screen for coeliac disease in
the presence of IgA deficiency and to define the sensitivity of a pathway using this
method (Figure1).
Method
All IgA and IgG anti-tTG tests performed at our centre between January 2008 and
December 2009, using the Immunocap 250 analyser, were retrospectively reviewed.
Positive results were correlated with histology. Results were used to validate our
diagnostic pathway.
Results
12,289 consecutive serological tests were reviewed. IgA deficient patients gave either
an “error” reading or very low response on the Immunocap 250 analyser. Subsequent
testing of this sub-group demonstrated raised IgG anti-tTG antibodies in those with
histologically proven coeliac disease.
Conclusions
Using our antibody screening pathway, which involves the selective use of IgG antitTG,
sensitivity increased from 87% to 92% in those with IgA deficiency. Adoption
of this pathway for coeliac screening would negate the routine screening of
immunoglobulin levels, with resultant cost saving
InvenioRDM GitHub Archiver (IGA) – Release 1.0.0
No full textThis is the first full release of IGA, the InvenioRDM GitHub Archiver. This release supports the use of IGA as both a command-line program and as a GitHub Action. Complete documentation is available at https://caltechlibrary.github.io/iga/ and a shortened version of the documentation is present in the repository README file.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) lets you automatically archive GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – Release 1.1.0
No full textNew features:
New option --print-doi makes IGA print the DOI of a published record in addition to printing the URL. (Without the option, IGA only prints the URL.)
Changes:
The color of text messages printed to the terminal has been changed slightly in an effort to improve readability.
The versions of some dependencies in requirements.txt have been updated.
Documentation has been updated and expanded.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) lets you automatically archive GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – Release 1.0.1
No full textChanges in this release:
Fix issue #8: parsing organization info sometimes results in an empty id string.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) lets you automatically archive GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – Release 1.0.2
No full textChanges in this release:
Fix issue #21: the copyright year put in the metadata dates field can could up being a completely bogus value in some cases.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) lets you automatically archive GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – Release 1.2.1
No full textChanges in this release:
Fixed setup.cfg, which had some garbled content.
Fixed the GitHub Action for building the IGA documentation pages to avoid needlessly running it on every push.
The GitHub Actions workflow (action.yml) for IGA now caches Python package dependencies for a slight speed up in run times on GitHub.
Added a GitHub Actions workflow to lint the code on pushes & pull requests.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) automatically archives GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – Release 1.0.3
No full textChanges in this release:
The sample workflow has been revised to be slightly more informative about where it's sending the release for archiving.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) lets you automatically archive GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
InvenioRDM GitHub Archiver (IGA) – CFF Updating
No full textThis release adds CFF updating as part of the example workflow.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/CHANGES.mdThe InvenioRDM GitHub Archiver (IGA) automatically archives GitHub releases in an InvenioRDM repository.Additional information is available at https://github.com/caltechlibrary/iga/blob/main/README.m
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