55 research outputs found
A New Planetary Boundary Layer Scheme Based on LES: Application to the XPIA Campaign
No full textsponsorship: This research has been supported and funded by the von Karman Institute for Fluid Dynamics. A portion of this work was performed at the Royal Observatory of Belgium. Sara Porchetta is an SB PhD fellow at FWO (Flemish Research Funds). NCEP Reanalysis data are provided by the NOAA/OAR/ESRL PSD, Boulder, Colorado, USA, from their website (http://www.esrl.noaa.gov/psd/).The planetary boundary layer scheme developed in this paper is available by request from the author Cem Berk Senel, as well as the simulation results. (von Karman Institute for Fluid Dynamics)status: Publishe
Somatic point mutation calling in low cellularity tumors
No full textSomatic mutation calling from next-generation sequencing data remains a challenge due to the difficulties of distinguishing true somatic events from artifacts arising from PCR, sequencing errors or mis-mapping. Tumor cellularity or purity, sub-clonality and copy number changes also confound the identification of true somatic events against a background of germline variants. We have developed a heuristic strategy and software (http://www.qcmg.org/bioinformatics/qsnp/) for somatic mutation calling in samples with low tumor content and we show the superior sensitivity and precision of our approach using a previously sequenced cell line, a series of tumor/normal admixtures, and 3,253 putative somatic SNVs verified on an orthogonal platform.Karin S. Kassahn, Oliver Holmes, Katia Nones, Ann-Marie Patch, David K. Miller, Angelika N. Christ, Ivon Harliwong, Timothy J. Bruxner, Qinying Xu, Matthew Anderson, Scott Wood, Conrad Leonard, Darrin Taylor, Felicity Newell, Sarah Song, Senel Idrisoglu, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, Anita Steptoe, Marina Pajic, Mark J. Cowley, Mark Pinese, David K. Chang, Anthony J. Gill, Amber L. Johns, Jianmin Wu, Peter J. Wilson, Lynn Fink, Andrew V. Biankin, Nicola Waddell, Sean M. Grimmond, John V. Pearso
O INDIVIDUO E A REVOLUÇÃO EM CUBA
No full textO presente trabalho objetiva discutir a relação entre História e Literatura, tomando como fonte de estudo o conto “Como um simples estudante” do contista cubano Senel Paz (1992). A Literatura se aproxima, cada vez mais, da História, tornando-se fonte privilegiada para estudos dos aspectos materiais e imateriais de uma sociedade. O conto, uma das mais complexas formas da produção literária, em função das suas especificidades, permite ao historiador estabelecer com ele um diálogo e, ao mesmo tempo, um interrogatório que revelam questões implícitas no texto que não são evidenciadas claramente pelo autor, mas que se constituem em evidencias motivadoras do debate de problemas históricos correntes na historiografia. Palavras-chave: Gênero. Literatura Cubana. Senel PazResumen El presente trabajo discute la relación entre Historia y Literatura, tomando como fuente de estudio el cuento “como un simple estudiante” del cuentista cubanos Senel Paz (1992). La Literatura se aproxima, cada vez más, de la Historia, convirtiéndose em fuente privilegiada para los estudios de los aspectos materiales e inmateriales de una sociedad. El cuento, una de las más complejas formas de produción literária, en función de sus especificidades, permite al historiador estabelecer con el un dialogo y, al mismo tempo, um interrogatório que revelan cuestiones implícitas en el texto que no son evidenciadas pero que se constituyen en evidencias motivadoras del debate de los problemas históricos corrientes en la historiografia. Palabras claves: Género. Literatura Cubana. Senel PazAbstract This paper aims to discuss the relation between History and Literature, taking as a study source the tale “Como um simples estudante” by the Cuban write Senel Paz (1992). Literature has joined History more and more, becoming privileged source to the studies of material and immaterial features of a society. The tale, one of the most complex ways of literaty Works, despite its specificities, allows the historian to establish a dialogue with it and, at the same time, a cross-examination that reveals implicit questions in the text, which are not clearly evidenced by the author, but become motivating evidences to the debate of current historic questions in historiography. Keywords: Gender. Cuban Literature. Senel Pa
O INDIVIDUO E A REVOLUÇÃO EM CUBA
No full textO presente trabalho objetiva discutir a relação entre História e Literatura, tomando como fonte de estudo o conto “Como um simples estudante” do contista cubano Senel Paz (1992). A Literatura se aproxima, cada vez mais, da História, tornando-se fonte privilegiada para estudos dos aspectos materiais e imateriais de uma sociedade. O conto, uma das mais complexas formas da produção literária, em função das suas especificidades, permite ao historiador estabelecer com ele um diálogo e, ao mesmo tempo, um interrogatório que revelam questões implícitas no texto que não são evidenciadas claramente pelo autor, mas que se constituem em evidencias motivadoras do debate de problemas históricos correntes na historiografia.
Palavras-chave: Gênero. Literatura Cubana. Senel Paz
Resumen
El presente trabajo discute la relación entre Historia y Literatura, tomando como fuente de estudio el cuento “como un simple estudiante” del cuentista cubanos Senel Paz (1992). La Literatura se aproxima, cada vez más, de la Historia, convirtiéndose em fuente privilegiada para los estudios de los aspectos materiales e inmateriales de una sociedad. El cuento, una de las más complejas formas de produción literária, en función de sus especificidades, permite al historiador estabelecer con el un dialogo y, al mismo tempo, um interrogatório que revelan cuestiones implícitas en el texto que no son evidenciadas pero que se constituyen en evidencias motivadoras del debate de los problemas históricos corrientes en la historiografia.
Palabras claves: Género. Literatura Cubana. Senel Paz
Abstract
This paper aims to discuss the relation between History and Literature, taking as a study source the tale “Como um simples estudante” by the Cuban write Senel Paz (1992). Literature has joined History more and more, becoming privileged source to the studies of material and immaterial features of a society. The tale, one of the most complex ways of literaty Works, despite its specificities, allows the historian to establish a dialogue with it and, at the same time, a cross-examination that reveals implicit questions in the text, which are not clearly evidenced by the author, but become motivating evidences to the debate of current historic questions in historiography.
Keywords: Gender. Cuban Literature. Senel Pa
Genomic analyses identify molecular subtypes of pancreatic cancer
No full textIntegrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing. Expression analysis defined 4 subtypes: (1) squamous; (2) pancreatic progenitor; (3) immunogenic; and (4) aberrantly differentiated endocrine exocrine (ADEX) that correlate with histopathological characteristics. Squamous tumours are enriched for TP53 and KDM6A mutations, upregulation of the TP63∆N transcriptional network, hypermethylation of pancreatic endodermal cell-fate determining genes and have a poor prognosis. Pancreatic progenitor tumours preferentially express genes involved in early pancreatic development (FOXA2/3, PDX1 and MNX1). ADEX tumours displayed upregulation of genes that regulate networks involved in KRAS activation, exocrine (NR5A2 and RBPJL), and endocrine differentiation (NEUROD1 and NKX2-2). Immunogenic tumours contained upregulated immune networks including pathways involved in acquired immune suppression. These data infer differences in the molecular evolution of pancreatic cancer subtypes and identify opportunities for therapeutic development.Peter Bailey, David K. Chang, Katia Nones, Amber L. Johns, Ann-Marie Patch, Marie-Claude Gingras, David K. Miller, Angelika N. Christ, Tim J. C. Bruxner, Michael C. Quinn, Craig Nourse, L. Charles Murtaugh, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Ehsan Nourbakhsh, Shivangi Wani, Lynn Fink, Oliver Holmes, Venessa Chin, Matthew J. Anderson, Stephen Kazakoff, Conrad Leonard, Felicity Newell, Nick Waddell, Scott Wood, Qinying Xu, Peter J. Wilson, Nicole Cloonan, Karin S. Kassahn, Darrin Taylor, Kelly Quek, Alan Robertson, Lorena Pantano, Laura Mincarelli, Luis N. Sanchez, Lisa Evers, Jianmin Wu, Mark Pinese, Mark J. Cowley, Marc D. Jones, Emily K. Colvin, Adnan M. Nagrial, Emily S. Humphrey, Lorraine A. Chantrill, Amanda Mawson, Jeremy Humphris, Angela Chou, Marina Pajic, Christopher J. Scarlett, Andreia V. Pinho, Marc Giry-Laterriere, Ilse Rooman, Jaswinder S. Samra, James G. Kench, Jessica A. Lovell, Neil D. Merrett, Christopher W. Toon, Krishna Epari, Nam Q. Nguyen, Andrew Barbour, Nikolajs Zeps, Kim Moran-Jones, Nigel B. Jamieson, Janet S. Graham, Fraser Duthie, Karin Oien, Jane Hair, Robert Grützmann, Anirban Maitra, Christine A. Iacobuzio-Donahue, Christopher L. Wolfgang, Richard A. Morgan, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Borislav Rusev, Paola Capelli, Roberto Salvia, Giampaolo Tortora, Debabrata Mukhopadhyay, Gloria M. Petersen, Australian Pancreatic Cancer Genome Initiative, Donna M. Munzy, William E. Fisher, Saadia A. Karim, James R. Eshleman, Ralph H. Hruban, Christian Pilarsky, Jennifer P. Morton, Owen J. Sansom, Aldo Scarpa, Elizabeth A. Musgrove, Ulla-Maja Hagbo Bailey, Oliver Hofmann, Robert L. Sutherland, David A. Wheeler, Anthony J. Gill, Richard A. Gibbs, John V. Pearson, Nicola Waddell, Andrew V. Biankin, Sean M. Grimmon
La metaficción en la novela cubana del Periodo Especial
No full textDespite having dissimilar purposes and results, the use of metafiction in Cuban narrative has been constant since the nineties. After establishing their context and placing them on the theoretical-critical map, the author analyzes El bosque, el lobo y el hombre nuevo by Senel Paz, La nada cotidiana by Zoé Valdés, Las bestias by Ronaldo Menéndez, La fiesta vigilada by Antonio José Ponte and La sombra del caminante by Ena Lucía Portela, in order to identify the use of different metafictional strategies and show their influence on the criticism of “the new man” and the symbolic imaginary of the Cuban Revolution.Aunque con disímiles propósitos y resultados, el empleo de la metaficción en la narrativa cubana ha sido constante desde la década de los noventa. Después de asentar el contexto de las narraciones y las coordenadas teórico-críticas, el presente ensayo analiza El bosque, el lobo y el hombre nuevo de Senel Paz, La nada cotidiana de Zoé Valdés, Las bestias de Ronaldo Menéndez, La fiesta vigilada de Antonio José Ponte y La sombra del caminante de Ena Lucía Portela para identificar el despliegue de diversas estrategias metaficcionales y mostrar cómo inciden en el cuestionamiento de la figura del hombre nuevo y del imaginario simbólico de la Revolución Cubana
Detective fiction in Cuban society and culture.
No full textPhDThe object of this thesis is to reach towards an understanding of Cuban society through a
study of its detective fiction and more particularly contemporary Cuban society through
the novels of the author and critic, Leonardo Padura Fuentes.
The method has been to trace the development of Cuban detective writing and to
read Padura Fuentes in the light of the work of twentieth century Western European
literary critics and philosophers including Raymond Williams, Antonio Gramsci, Terry
Eagleton, Roland Barthes, Jean Paul Sartre, Michel Foucault, Jean François Lyotard and
Jean Baudrillard in order to gain a better understanding of the social and historical
context from which this genre emerged.
By concentrating on the literary texts, I have explored readings which lead out into
an analysis of the broader philosophical, political and historical issues raised by the
Cuban revolution. Since it deals primarily with modes of deviance and notions of legality
and justice within the context of the modern state, detective fiction is particularly well
suited to this type of investigation. The intention is to show how this is as valid in the
Cuban context as it is in advanced capitalist societies where such research has already
been carried out with some success.
The thesis comprises an introduction, ten chapters and a conclusion. The chapters
are divided into three sections. Chapters 1 to 3 attempt a broad theoretical, historical and
socio-political analysis of the cultural reality within which the Cuban revolutionary
detective genre emerged. Chapters 4 to 6 analyse the Cuban detective narrative from its
inception in the early part of the twentieth century until the emergence of Leonardo
Padura Fuentes as the foremost exponent of the genre in Cuba after 1991. Chapters 7-
10 concentrate upon the work of Leonardo Padura Fuentes, offering a reading of his
detective tetralogy informed by the preceding discussion.
The contribution made by the thesis to knowledge of the subject is to build upon the
work of Seymour Menton and Amelia S. Simpson on the development of the Cuban
detective novel and to provide analyses of the pre-Revolutionary Cuban detective
narrative and the work of Leonardo Padura Fuentes for the first time in the English
language. The thesis concludes that the study of this popular genre in Cuba is of crucial
importance to the scholar who wishes to reach as full an understanding of the social
dynamics within that society as possible. In particular, it proves that Cuban detective
fiction provides a useful barometer of social change which records the shifts in the Cuban
Zeitgeist that have taken place over the past century
Exposure-Tolerant Imaging Solution forCultural Heritage Monitoring
No full textThis paper describes a simple and cheap solution specifically designed for monitoring the degradation of thin coatings employed for metal protection. The proposed solution employs a commercial photocamera and a frequency-domain-based approach that is capable of highlighting the surface uniformity changes due to initial corrosion. Even though the proposed solution is specifically designed to monitor the long-time performance of protective coatings employed for the restoration of silver artifacts, it can be successfully used also for assessing the conservation state of other ancient metallic works of art. The proposed solution is made tolerant to exposure changes by using a procedure for sensor nonlinearity identification and correction, does not require a precise lighting control, and employs only free open-source software, so that its overall cost is very low and can be used also by not specifically trained operator
The effects of financial liberalization and new bank entry on market structure and competition in Turkey
No full textUntil 1980 Turkey's financial system was shaped to support state-oriented development. After the 1960s the financial system, dominated by commercial banks, became an instrument of planned industrialization. Turkey had an uncompetitive financial market and an inefficient banking system. Controlled interest rates, directed credit, high reserve requirements and other restrictions on financial intermediation, and restricted entry of new banks -plus the exit of many banks between 1960 and 1980- created a concentrated market dominated by banks owned by industrial groups with oversized branch networks and high overhead costs. Turkey since 1980 has seena trend toward liberalization of its financial market. Reforms eliminated interest rate controls, eased the entry of new financial institutions, and allowed new types of instruments. Regulatory barriers were relaxed, attracting many banks (both Turkish and foreign) into the system, and Turkey's banking system became integrated with world markets. The author examines how reform has changed the system, focusing on Turkey's commercial retail banking market. He finds that: (1) Although reform reduced concentration in the industry, leading banks are still able to coordinate their pricing decisions overtly. High profitability appears to have resulted from the banks uncompetitive pricing rather their efficiency. Deregulation and liberalization should be continued and strengthened. (2) The entry of small-scale firms alone is not enough to increase competition, so new banks should probably not be expected to alter the market structure. (3) To promote competition will require addressing barriers to both entry and mobility. The main barrier to mobility seems to be the size of the large banks, which exerts a significant negative effect on competition. (4) Interbank rivalry among the leading banks cannot be facilitated without creating new banks of a certain size with a reasonable number of branches. Breaking up public banks (which hold 30 percent of sectional assets, excluding the Agricultural Bank and three development banks) could help create 15 to 20 new banks with 40 to 50 branches. This would reduce concentration and improve mobility in retail banking. (5) Breaking up public banks before privatization would probably also improve their governance structures and efficiency. (6) Promoting the entry of nonbanks and local banks would also increase the number of institutions competing for deposits. Turkey lacks a healthy variety of credit institutions and should consider developing a mortgage market and creating institutions for housing finance.Payment Systems&Infrastructure,Financial Intermediation,Economic Theory&Research,Banks&Banking Reform,Markets and Market Access,Banks&Banking Reform,Financial Intermediation,Economic Theory&Research,Markets and Market Access,Access to Markets
mRNA vaccine quality analysis using RNA sequencing
No full textAbstract The success of mRNA vaccines has been realised, in part, by advances in manufacturing that enabled billions of doses to be produced at sufficient quality and safety. However, mRNA vaccines must be rigorously analysed to measure their integrity and detect contaminants that reduce their effectiveness and induce side-effects. Currently, mRNA vaccines and therapies are analysed using a range of time-consuming and costly methods. Here we describe a streamlined method to analyse mRNA vaccines and therapies using long-read nanopore sequencing. Compared to other industry-standard techniques, VAX-seq can comprehensively measure key mRNA vaccine quality attributes, including sequence, length, integrity, and purity. We also show how direct RNA sequencing can analyse mRNA chemistry, including the detection of nucleoside modifications. To support this approach, we provide supporting software to automatically report on mRNA and plasmid template quality and integrity. Given these advantages, we anticipate that RNA sequencing methods, such as VAX-seq, will become central to the development and manufacture of mRNA drugs
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