1,721,102 research outputs found

    [Assessment of occupational risk of Legionella spp. infection among dental health-care personnel]

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    Various authors have reported the presence of Legionella spp. in dental unit waterlines with prevalence rates reaching, in some cases, 69.7% In order to evaluate the association between occupational exposure to Legionella and risk of infection, anti-Legionella spp. antibodies were measured in 88 dental assistants, 44 of which exposed and 44 not exposed to dental environments. Antibody levels > 1:128 were considered positive for infection. Relative risk was found to be 3.5 (p<0.01). These results confirm the hypothesis that workers in dental health-care settings are at occupational risk for Legionella infection. It is essential, therefore, that surveillance of microbiological quality of dental waterlines be implemented and appropriate disinfection procedures performed where necessary

    Antifungal susceptibility testing of a 10-year collection of Candida spp. isolated from patients with candidemia.

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    Nosocomial yeast infections have increased significantly worldwide and especially in surgical and intensive care unit (ICU) patients. Although Candida species have various degrees of susceptibility to frequently used drugs, antifungal resistance is rare. A ten-year retrospective surveillance of candidemia was carried out in a University Hospital of Southern Italy. The aim of this study was the determination of Candida bloodstream infections (BSI) and central venous catheter (CVC)-related episodes, prevalence and in vitro susceptibility. 320 candidemia episodes were registered and 374 yeasts collected. Etest and Sensititre methods were used to test the isolates' susceptibility to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole, posaconazole and voriconazole. The results were compared with those of CLSI reference broth microdilution method. Most yeasts were susceptible to all antifungal drugs, with the exception of C. glabrata susceptibility to triazoles and C. tropicalis to fluconazole and voriconazole. As expectedC. parapsilosis isolates were generally associated with higher echinocandin minimum inhibitory concentrations (MICs) than the other Candida species. This study confirms the different antifungal susceptibility patterns among species, and underlines the need to perform antifungal susceptibility testing of clinically relevant yeasts
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