332 research outputs found
Опыт лечения препаратом секукинумаб пациента с псориазом тяжелой степени тяжести, ассоциированным с ВИЧ-инфекцией
No full textPsoriasis is a chronic, immune-mediated, genetic disorder characterized by skin lesions and musculoskeletal system injuries and affected by external and internal factors. Currently, one of the primary challenges in modern dermatovenereology is managing patients with chronic dermatoses including moderate-to-severe psoriasis. This article presents a case narrative concerning the use of secukinumab, an IL-17A inhibitor, in an HIV-positive patient with severe psoriasis and psoriatic arthritis. The disease course was characterized by significant cutaneous and articular syndromes along with resistance to disease modifying anti-rheumatic therapy. Secukinumab treatment of this patient helped to improve both dermatological and musculoskeletal symptoms. The safety and high efficacy of secukinumab enable complete disease control and improve the quality of life in patients with moderate-to-severe plaque psoriasis emphasizing the need for the use of genetically engineered biological drugs.Псориаз — хроническое иммуноопосредованное, генетически обусловленное заболевание, которое характеризуется поражением кожи и опорно-двигательного аппарата и зависит от внешних и внутренних факторов. На сегодняшний день одной из главных задач в современной дерматовенерологии является лечение пациентов с хроническими дерматозами, в том числе с псориазом среднетяжелой и тяжелой степени тяжести. В статье представлен клинический случай применения препарата секукинумаб, относящегося к группе ингибиторов IL-17А, у ВИЧ-инфицированного пациента с псориазом тяжелой степени тяжести и псориатическим артритом. Течение заболевания характеризовалось выраженным кожным и суставным синдромами, а также резистентностью к базисной противовоспалительной терапии. Применение в лечении данного пациента препарата секукинумаб помогло достичь снижения клинических проявлений со стороны как кожи, так и опорно-двигательного аппарата. Безопасность и высокая эффективность препарата секукинумаб позволяют полностью контролировать течение заболевания и улучшают качество жизни пациентов, страдающих бляшечным псориазом среднетяжелой и тяжелой степени тяжести, а также свидетельствуют о необходимости применения генно-инженерных биологических препаратов
Review of the Monograph “Colour. City. Culture” by O.E. Zheleznyak
No full textThe author of the review, professor I. A. Dobritsyna evaluates the Monograph “Colour. City. Culture” by O.E. Zheleznyak as a distinctive work. This thorough and methodically organized monograph presents a profound idea of the colour phenomenon as a part of the culture and the city life and observes a new untraditional treatment of colour and its role in the space of culture and the city. This work can be recommended as a scientific publication for a wide range of specialists and as a manual for higher educational institutions, which train specialists in architecture and design, monumental-decorative and decorative-applied arts
L'apport de la théorie des organisations à la conception néo-institutionnelle de la firme. Une relecture des travaux de O.E. Williamson
No full textThe contribution of the organization theory to the neoinstitutionnalist conception of the firm: a rereading of the works of O.E. Williamson
In this text, the author makes a reflection about the contribution of the organization theory to the neoinstitutionnalist conception of the firm, by proceeding to a rereading of the works of O. Williamson. This borrowing, in contrast to others theories of the firm, permits to highlight numerous aspects of the firm, namely: the contractual nature of the firm, the nature of intrafirm conflict and the organizational dynamic of the firm. Moreover, the author studies the complementarities and the differences between this borrowing and another current of the organization theory, the strategic analysis one. This comparison leads us, as Williamson suggest, to build a "science of organization".L'apport de la théorie des organisations à la conception néo-institutionnelle de la firme. Une relecture des travaux de O.E. Williamson
L'auteur s'interroge dans ce texte sur l'apport de la théorie des organisations à la conception néo-institutionnelle de la firme, en procédant à une relecture de l'ensemble des travaux de O.E. Williamson. Grâce à cet emprunt, Williamson enrichit notablement le traitement de la firme par rapport aux autres théories économiques, sur trois points principaux : la nature contractualiste de la firme, la nature du conflit intrafirme et la dynamique organisationnelle de la firme. Par ailleurs, l'auteur étudie les complémentarités et les divergences entre cet emprunt et un autre courant de la théorie des organisations, celui de l'analyse stratégique. Cette confrontation permet d'avancer dans la construction de ce que Williamson appelle la « science de l'organisation ».Baudry Bernard. L'apport de la théorie des organisations à la conception néo-institutionnelle de la firme. Une relecture des travaux de O.E. Williamson. In: Revue économique, volume 50, n°1, 1999. pp. 45-69
L'apport de la théorie des organisations à la conception néo-institutionnelle de la firme. Une relecture des travaux de O.E. Williamson
No full text[fre] L'apport de la théorie des organisations à la conception néo-institutionnelle de la firme. Une relecture des travaux de O.E. Williamson. . L'auteur s'interroge dans ce texte sur l'apport de la théorie des organisations à la conception néo-institutionnelle de la firme, en procédant à une relecture de l'ensemble des travaux de O.E. Williamson. Grâce à cet emprunt, Williamson enrichit notablement le traitement de la firme par rapport aux autres théories économiques, sur trois points principaux : la nature contractualiste de la firme, la nature du conflit intrafirme et la dynamique organisationnelle de la firme. Par ailleurs, l'auteur étudie les complémentarités et les divergences entre cet emprunt et un autre courant de la théorie des organisations, celui de l'analyse stratégique. Cette confrontation permet d'avancer dans la construction de ce que Williamson appelle la « science de l'organisation ». [eng] The contribution of the organization theory to the neoinstitutionnalist conception of the firm: a rereading of the works of O.E. Williamson. . In this text, the author makes a reflection about the contribution of the organization theory to the neoinstitutionnalist conception of the firm, by proceeding to a rereading of the works of O. Williamson. This borrowing, in contrast to others theories of the firm, permits to highlight numerous aspects of the firm, namely: the contractual nature of the firm, the nature of intrafirm conflict and the organizational dynamic of the firm. Moreover, the author studies the complementarities and the differences between this borrowing and another current of the organization theory, the strategic analysis one. This comparison leads us, as Williamson suggest, to build a "science of organization".
“Well: live long, black earth” (Nu, zdravstvuy, chernozem…): “I” of the author in the “chernozem” poetic “nest” of O. Mandelstam
No full textThe article explores the variety of voices of an author in the group of “black earth” (“chernozem”) poems written by O.E. Mandelstam in 1935, the character of relations among them, polyvalency of the key image of “soil – black earth – vegetable garden”. The author analyzes the peciliarities of rythmic patterns, specific character of a metaphor, the character of associative links in poetry of the later years of Osip Mandelstam
The effectiveness of self-supervised representation learning in zero-resource subword modeling
No full textFor a language with no transcribed speech available (the zero-resource scenario), conventional acoustic modeling algorithms are not applicable. Recently, zero-resource acoustic modeling has gained much interest. One research problem is unsupervised subword modeling (USM), i.e., learning a feature representation that can distinguish subword units and is robust to speaker variation. Previous studies showed that self-supervised learning (SSL) has the potential to separate speaker and phonetic information in speech in an unsupervised manner, which is highly desired in USM. This paper compares two representative SSL algorithms, namely, contrastive predictive coding (CPC) and autoregressive predictive coding (APC), as a front-end method of a recently proposed, state-of-the art two-stage approach, to learn a representation as input to a back-end cross-lingual DNN. Experiments show that the bottleneck features extracted by the back-end achieved state of the art in a subword ABX task on the Libri-light and ZeroSpeech databases. In general, CPC is more effective than APC as the front-end in our approach, which is independent of the choice of the out-domain language identity in the back-end cross-lingual DNN and the training data amount. With very limited training data, APC is found similar or more effective than CPC when test data consists of long utterances.Accepted author manuscriptMultimedia Computin
‘Pervaia kniga A. S. Suvorina’.
No full text© O.E. Makarova 2009, who is the author of chapter VI, 'Pervaia kniga A. S. Suvorina', in Kniga: issledovaniia i materialy, Sbornik 92/I-II
Analytic Solutions of Elastic Tunneling Problems
No full textThe complex variable method for solving two dimensional linearly elastic problems is used to obtain several fundamental analytical solutions of tunneling problems. The method is used to derive the general mathematical representation of problems involving resultant forces on holes in a half-plane. Such problems are encountered in geomechanics during the excavation of tunnels. When tunnels are excavated the removal of the weighted material inside the tunnel causes the ground under the tunnel to rebound. This in turn causes a resultant force, referred to here as the buoyancy force, to act on the tunnel until the stresses return to a state of equilibrium. The mathematical representation derived in this thesis shows that the displacements will usually be unbounded at infinity in solutions of two-dimensional problems involving resultant forces acting on holes in a half-plane. A general solution is derived for a single, circular tunnel in an elastic halfplane that includes a buoyancy force. The boundary conditions in this solution are that the surface of the half-plane is stress-free and that the displacements are specified along the tunnel boundary. This general solution is used in the rest of the thesis as the framework for considering three fundamental tunneling problems: the problem of a rigid, buoyant tunnel, the ground loss problem, and the ovalization problem. The three fundamental solutions are combined to illustrate their possible use as tools for the prediction of settlement troughs. The inclusion of buoyancy effects in the solution is shown to have a possibly considerable narrowing effect on settlement troughs. Neglect of the buoyancy effect might well be a reason why settlement troughs calculated in theory are often wider than those measured in practice.Civil Engineering and Geoscience
Novel design methods for high-quality lithographic objectives
No full textThis thesis discusses some of the challenges of optical design for Extreme Ultraviolet (EUV) mirror systems and illustrates novel design techniques and their application to, preponderantly, EUV systems and, in addition, some Deep Ultraviolet (DUV) lithographic objectives. The main added value of this thesis is the fact that it shows how scientific results can be used for the design of complex lithographic systems.Applied Science
Using cross-model learnings for the Gram Vaani ASR Challenge 2022
No full textIn the diverse and multilingual land of India, Hindi is spoken as a first language by a majority of its population. Efforts are made to obtain data in terms of audio, transcriptions, dictionary, etc. to develop speech-technology applications in Hindi. Similarly, the Gram-Vaani ASR Challenge 2022 provides spontaneous telephone speech, with natural back-ground and regional variations in Hindi. The challenge provides: 100 hours of labeled train-set, 5 hours of labeled dev-set and 1000 hours of unlabeled data-set. For the 'Closed Challenge', we trained an End-to-End (E2E) Conformer model using speed perturbations, SpecAugment techniques and use VTLN to handle any unknown speaker groups in the blind evaluation set. On the dev-set, we achieved a 30.3% WER compared to the 34.8% WER by the Challenge E2E baseline. For the 'Self Supervised Closed Challenge', a semi-supervised learning approach is used. We generate pseudo-transcripts for the unlabeled data using a hybrid TDNN-3gram LM model and trained an E2E model. This is then used as a seed for retraining the E2E model with high confidence data. Cross-model learning and refining of the E2E model gave 25.3% WER on the dev-set compared to ∼33-35% WER by the Challenge baseline that use wav2vec models.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Multimedia Computin
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