38 research outputs found
A study of the relationship between social factors and certain aspects of language usage, 1954
No full textRecommended from our members
Post-Transcriptional Gene Regulation by N6-Methyladenosine and Selective RNA Binding Proteins
No full textRegulation of genetic output is a complex biological phenomenon that allows cells with identical genetic material to enable diverse phenotypic outcomes. Epigenetics is the study of factors that change gene expression without perturbing the underlying genetic sequence. Mechanisms of epigenetics feature a multitude of chemical modifications to DNA as well as accompanying histone proteins, which tune the transcriptional output in a reversible manner. Recently, the concept of reversible RNA epigenetics has emerged as a mechanism to regulate gene expression post-transcriptionally. N6-methylasdenosein (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). This RNA modification is recognized by m6A-selective RNA binding protein of the YTH family, which incorporate modified RNAs into canonical pathways for mRNA metabolism. In this work, we describe the function of the only nuclear YTH protein YTHDC1 in promoting the nuclear export of methylated mRNAs by interaction with the splicing and export adaptor protein SRSF3. We then turn to a biological example of rapid mRNA processing during progression through the cell cycle. We propose that m6A modifications serve roles in the dynamic regulation of the cellular transcriptome
A Middle-Class African-American Child in Desegregating Savannah: The Reminiscences of Justice Leah Ward Sears
No full textA biography of former Supreme Court of Georgia Chief Justice Leah Ward Sears is presented, focusing on her early years. It comments on her parents, Thomas Euric Sears and Onnye Jean Roundtree Sears, and her experiences growing up in a military family. The author particularly reflects on Ward\u27s time in Savannah, Georgia. Her education at Savannah High School and Emory University School of Law is also considered
The effects of price and brand on consumers' perceptions of service quality, service value and behavioral intentions: Pre-purchase versus post-purchase
No full textThis dissertation synthesizes previous research from consumer research, psychology and applied economics to develop a conceptual model explaining the effects of perceived price and perceived brand on consumers' pre-purchase service expectations. This research also addresses the extent consumers' perceptions of value mediate the relationship between consumers' perceived service quality (i.e., pre-purchase expectations of service and post-purchase evaluations of actual service) and their behavioral intentions (e.g., willingness to buy and search intentions).The objective of this dissertation was to develop and test a conceptual model which: (1) helps explain the effects of perceived price and perceived brand on consumers' pre-purchase expected service quality and (2) addresses the extent consumers' perceptions of value mediate the relationship between consumers' perceived service quality (i.e., pre-purchase expectations of service or post-purchase evaluations of actual service) and their behavior intentions (e.g., willingness to buy and search intentions).To test this model and its propositions, an experiment was conducted. Respondents evaluated a hotel service given variations in advertised price, brand name and actual service performance. A confirmatory factor analytic computer program was used to assess the measurement properties of the scales. Manipulation effects were tested using analysis of variance techniques and certain relationships were tested using correlation and regression analyses.Twelve of the fourteen hypothesized effects and relationships were supported by the empirical results. The results of the brand and price manipulations in the pre-purchase stage were very robust. The results also suggest that consumers rely more on information provided in the pre-purchase stage (i.e., price and brand name) to make evaluations in the pre-purchase. Conversely, post-purchase evaluations were dominated more by experience. Support was also found for a mediating role of service value in consumers' evaluations of willingness to buy and search intentions in both pre-purchase and post-purchase stages. Finally, the results also suggest a moderating role for actual service performance in consumers' evaluation of post-purchase perceived monetary sacrifice.Made available in DSpace on 2011-05-07T13:11:26Z (GMT). No. of bitstreams: 2
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ChemInform Abstract: Ni‐ and Pd‐Catalyzed Synthesis of Substituted and Functionalized Allylic Boronates.
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