1,721,167 research outputs found
Re: Ian D. Davis, Wanling Xie, Carmel Pezaro, et al. Efficacy of Second-line Targeted Therapy for Renal Cell Carcinoma According to Change from Baseline in International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Category. Eur Urol 2017;71:970-8: The Change in Baseline IMDC Prognostic Category: From the Past, Implications for the Future
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The End of Chemotherapy in Renal Cell Carcinoma: For Much But Not for All
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Study design and clinical evidence in mRCC: Can we save axitinib as a first-line therapy?
No full textPost-docetaxel therapy in castration resistant prostate cancer - the forest is growing in the desert.
Full text linkIn Europe, prostate cancer is the most common cancer among men with 382.000 new cases and 89.000 deaths annually. Historically, androgen deprivation therapy and docetaxel based chemotherapy were the only treatments able to improve survival. Two studies have been published during last few months regarding the management of castration resistant prostate cancer (CRPC) progressed after docetaxel: for the first time second line therapies have been demonstrated to improve prognosis of these patients. The relevance of these trials is the reintroduction of chemotherapy and hormonal therapy in a disease once considered chemotherapy and castration resistant. All these data may change the traditional approach to CRPC but no evidences have came out from recently closed or ongoing clinical trials about the therapeutic algorithm. How to get oriented in this forest? We propose that patient's conditions, response and toxicities reported with previous treatments and, above all, dynamics and evolution of disease may influence the choice of subsequent therapies in docetaxel progressed CRPC. © The Author(s), 2012
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