1,721,126 research outputs found

    Un modello di malattia da poliglutammine: clinica e diagnosi della Corea di Huntington

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    La corea di Huntington (Corea major) è una grave patologia degenerativa su base genetica del Sistema Nervoso, descritta nel 1872 da George Huntington, che porta inevitabilmente alla perdita delle funzioni motorie, a ritardo mentale e a morte precoce. Tale malattia insorge in età adulta, generalmente intorno ai 35 anni. Sono stati tuttavia descritti casi ad insorgenza precoce, intorno ai 15-16 anni. Solo all’inizio del XX secolo si riconobbe l’esistenza di un processo atrofico-degenerativo interessante il neo-striato e la corteccia cerebrale, quale responsabile del quadro sintomatologico. Di seguito descriviamo sia alcuni aspetti clinici che molecolari di questa malattia, quale modello di malattia neurodegenerativa su base genetica

    Influence of gender role orientation (masculinity versus femininity) on body satisfaction and eating attitudes in homosexuals, heterosexuals and transsexuals

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    The primary aim of this study was to investigate the relationship between gender role orientation and eating disorder attitudes and behaviors and body dissatisfaction in a sample of homosexuals, heterosexuals, and transsexuals. We screened 132 homosexuals, 178 heterosexuals (both male and female), and 15 MtF transsexuals by means of an ad hoc socio-demographic schedule; the Eating Disorders Inventory-2 and Symptom Checklist; the Body Uneasiness Test and the Bem Sex Role Inventory. Differences between homosexual, heterosexual, and transsexual participants emerged, but those data seem to be best explained by the constructs of femininity and masculinity than by the biological gender. The empirical evidence of a positive correlation between femininity and eating problems, and the negative correlation between masculinity and eating problems, is full of implications. Eating disorders appear to be diseases of femininity; masculinity seems to be a protective factor, independently by the biological gender

    Muscle Dysmorphia: A comparison between competitive bodybuilders and fitness pratictioners

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    Objective: The primary aim of this study was to investigate the features of Muscle Dysmorphia and other body image-related concerns in a sample of competitive male bodybuilders. Method: We screened 217 male athletes, 119 bodybuilders and 98 fitness practitioners, recruited in 12 gymnasiums in Southern Italy, by means of an ad hoc socio-demographic schedule, the Muscle Dysmorphia Inventory (MDI) and the Muscle Appearance Satisfaction Scale (MASS). Results: Twenty one of the bodybuilders (17.6%) show high levels of preoccupation and dissatisfaction with their muscularity, 45.4% (N=54) a marked dependence on bodybuilding; 35.3% (N=42) follow a high-protein diet and 35.3% (N=42) used vitamin supplements to improve their weightlifting performances and favor post-training physical recovery. In addition, forty-three (36.1%) also report use of substance while nine subjects (7.6%) declare to avoid situations in which their body might be seen or manifest high levels of distress when this happens. The ANCOVA (Exercise Frequency per Week as a covariate) results indicate that bodybuilders, compared to fitness practitioners, report significant elevations in all measures. Moreover, considering only the bodybuilders sample, who report a regular use of substance scored higher in Dietary Behavior, Body size-symmetry, Physique Protection, Supplement Use MDI scales and on Body building Dependence, Muscle Checking and Injury MASS subscales. Discussion: Our findings seem to suggest that the practice of the bodybuilding is associated to the proposed criteria of muscle dysmorphia if compared with regular fitness practice. In particular, we found that a regular use of substance was associated with greater dissatisfaction with muscularity
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