1,706 research outputs found
Antibody-drug conjugates: targeted weapons against cancer
No full textAntibody drug conjugates (ADCs) are formed by a targeting antibody conjugated to a chemotherapeutic molecule through a linker. Recent data demonstrate that they represent a valuable advancement for the clinics and, despite their recent appearance, they are already undergoing an innovation wave aimed at targeting all their three building blocks. Thus, new antibody formats are being engineered, site-specific linkers are being designed and highly toxic molecules, like RNA polymerase inhibitors, start to be used for conjugation. These molecules were previously considered extremely toxic and could not be used as chemotherapeutic drugs. In this review, we will go through an overview of current cancer treatments and their limitations, and the logic which has led to the generation of ADCs. Their mechanism of action will be outlined and the most recent novelties in linker design and optimization will be discussed, along with present and near future of the current ADC pipeline
Luisa Igloria, 36th Annual ODU Literary Festival
No full textLuisa Igloria is an award -winning poet, and the author of The Saints of Streets (University of Santo Tomas Publishing House, Fall 2013), Juan Luna\u27s Revolver (University of Notre Dame Press, 2009 Ernest Sandeen Prize), Trill & Mordent (WordTech Editions, 2005), and 8 other books. Luisa has degrees from the University of the Philippines, Ateneo de Manila University, and the University of Illinois at Chicago, where she was a Fulbright Fellow from 1992-1995. Luisa teaches in and currently directs the MFA Creative Writing Program at Old Dominion University
Luisa A, Igloria, 37th Annual ODU Literary Festival
No full textLUISA A. IGLORIA is a professor and director of the MFA Creative Writing Program at ODU. She is the author of Ode to the Heart Smaller than a Pencil Eraser (2014 May Swenson Prize, University of Utah Press); Night Willow: Prose Poems (2014); The Saints of Streets (2013); Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize); Trill & Mordent (2005); and eight other books. Luisa was a Fulbright Fellow from 1992-95 at the University of Illinois at Chicago. Since Nov. 20, 2010, she has written (at least) a poem a day, archived at www.vianegativa.us/author/luisa/
Ingegnerizzazione di mAb per scopi teraupeutici
No full textLa quinta edizione di Farmacologia generale e molecolare mantiene l'impostazione originale che ne ha fatto un volume unico nel panorama editoriale, ponendo al centro dell'attenzione il bersaglio molecolare del farmaco anziché il composto chimico. Al tempo stesso si presenta ai lettori profondamente rinnovata: oltre ai necessari aggiornamenti di una materia in rapido sviluppo, che hanno portato a un'ampia revisione di tutti i capitoli, nell'ultimo decennio è mutato il contesto biomedico, spostando l'interesse sul malato che è, e deve sempre più essere, protagonista attivo della scelta terapeutica. Questa lenta ma progressiva rivoluzione culturale ha portato cambiamenti anche nel modo di concepire e sviluppare i farmaci, nella legislazione che governa la loro immissione in commercio e nell'assetto della filiera produttiva del farmaco. Inserendo nuovi capitoli e nuovi Autori, il libro affronta questi temi e le nuove tecnologie che offrono una conoscenza sempre più approfondita dei determinanti molecolari delle patologie e della loro modulazione farmacologica, una maggiore efficacia e specificità nell'azione complessiva dei farmaci e una minore tossicità. Tra le principali novità, vi sono l'ampia rivisitazione degli aspetti riguardanti il drug discovery, temi innovativi portati dalla nanotecnologia e dalle biotecnologie e la discussione degli sviluppi della farmacologia verso la terapia personalizzata. Capitoli inediti trattano la farmacologia di genere e gli aspetti tossicologici della farmacologia e della farmacoterapia. Il libro si conclude con l'analisi critica del futuro della farmacologia mondiale, di particolare utilità per chi vuole intraprendere la carriera di farmacologo. Farmacologia generale e molecolare dispone online, su studenti33.it, di preziosi contenuti aggiuntivi: l'iconografia completa del volume e una ricca selezione di approfondimenti per la preparazione avanzata in ambito farmacologico, quasi un secondo volume che completa il testo cartaceo
Luisa Igloria, 28th Annual ODU Literary Festival
No full textLuisa Igloria (previously published as Maria Luisa A. Carino) is the author of six books, four of which received the National Book Award from the Manila Critics’ Circle: Blood Sacrifice (University of the Philippines Press, 1998); Encanto (Anvil, 1994); Cartography (Anvil, 1992); and Cordillera Tales (New Day, 1990). She is also the author of In the Garden of the Three Islands (Moyer Bell/Asphodel, 1995), and the editor of Not Home, But Here: Writing from the Filipino Diaspora (Anvil, 2003). Her seventh and most recent book is Trill & Mordent (WordTech Editions, 2005), a runner-up for the 2004 Editions Prize. Igloria’s work has appeared in numerous national and international journals; she has received prestigious honors that include the 2004 Fugue Poetry Award, Finalist for the 2004 Larry Levis Editors Prize for Poetry, and Finalist for the 2003 Dorset Prize (Tupelo Press). She has received fellowships from the Fulbright Foundation, the Hawthornden Castle in Scotland, and to the Summer Literary Seminars in St. Petersburg, Russia. Igloria is an associate professor on the faculty of ODU’s Creative Writing Program
Luisa A. Igloria, 43rd Annual Literary Festival
No full textLuisa A. Igloria was recently appointed Virginia Poet Laureate (2020-2022). She is the 2019 co-winner of the Crab Orchard Open Poetry competition for Maps for Migrants and Ghosts (Fall 2020) and winner of the 2015 Resurgence Prize (U.K.), the world\u27s first major award for ecopoetry. She is the author of four chapbooks plus 14 full-length works, including The Buddha Wonders if She is Having a Mid-Life Crisis (2018), Ode to the Heart Smaller than a Pencil Eraser (2014 May Swenson Prize), and Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize). She teaches in ODU\u27s MFA Program in Creative Writing
Luisa González
No full textThis is a testimonial of the representation of the play entitled A ras del suelo, by Luisa González. This deals with the initial encounter with the author, her knowledge and the begin- ning of a wonderful and enriching friendship among Luisa González and the Costa Rican actress Eugenia Cheverri.Es un testimonio de la génesis de la puesta en escena de la obra “A ras del suelo” de Luisa González. El encuentro inicial, físico con ella, su participación como autora, y el inicio de una hermosa amistad entre la escritora del relato y la gente de teatro costarricense en los años setenta
Luisa Igloria, 41st Annual ODU Literary Festival
No full textLuisa A. Igloria is the winner of the 2015 ResurgencePrize (UK), the world\u27s first major award for ecopoetry, selected by former UK poet laureate Sir Andrew Motion, Alice Oswald, and Jo Shapcott. She is the author of three chapbooks plus the full length works The Buddha Wonders if She is Having a Mid-Life Crisis (Phoenicia Publishing, Montreal; March 2018), Ode to the Heart Smaller than a Pencil Eraser (selected by Mark Doty for the 2014 May Swenson Prize, Utah State University Press), Night Willow (Phoenicia Publishing, Montreal, 2014),The Saints of Streets (University of Santo Tomas Publishing House, 2013), Juan Luna\u27s Revolver (2009 Ernest Sandeen Prize, University of Notre Dame Press), and nine other books. She teaches on the faculty of the MFA Creative Writing Program at Old Dominion University, which she directed from 2009-2015
Luisa A. Igloria: 47th Annual ODU Literary Festival
No full textLuisa A. Igloria is the author of Caulbearer (Immigrant Writing Series Prize, Black Lawrence Press, 2024), Maps for Migrants and Ghosts (Co-Winner, 2019 Crab Orchard Open Poetry Prize), The Buddha Wonders if She is Having a Mid-Life Crisis (2018), 12 other books, and 4 chapbooks. With Aileen Cassinetto and Jeremy S. Hoffman, she co-edited Dear Human at the Edge of Time: Poems on Climate Change in the U.S. (Paloma Press, 2023), offered as a companion to the Fifth National Climate Assessment (NCA5). Originally from Baguio City, she makes her home in Norfolk VA where she is the Louis I. Jaffe and University Professor of English and Creative Writing at Old Dominion University’s MFA Creative Writing Program. She also leads workshops for and is a member of the board of The Muse Writers Center in Norfolk. Luisa is the 20th Poet Laureate of the Commonwealth of Virginia (2020-22), Emerita. During her term, the Academy of American Poets awarded her a 2021 Poet Laureate Fellowship
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