191 research outputs found
Analysis of Surface Water Key Pollutants of the Tributaries of the Danube River in Bulgarian Section
No full text[Filipova M.; Филипова М.]; [Zheleva I.; Желева И.]; [Lecheva A.; Лечева А.]; [Rusev P.; Русев П.]Based on official data, a comparative analysis of the surface water along the rivers flowing into the Danube River in the transborder area Bulgaria– Romania is presented. The content of dissolved oxygen, nitrate nitrogen and Biological and Chemical Oxygen Demand (BOD5 and COD) for a five year period 2009–2013 is analyzed. The aim is the dynamics of these indicators and the reasons for the current exceedances to be traced and analyzed. Measures for improving the condition of the surface runoff are also proposed. 2010 Mathematics Subject Classification: 62-07, 62P12, 92F99
Microscopic Examination of SiO<sub>2</sub>/<i>4H</i>-SiC Interfaces
No full textSiO2/4H-SiC interfaces are examined by high-resolution transmission electron microscopy (HRTEM), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and spatially resolved electron energy-loss spectroscopy (EELS). HRTEM and HAADF-STEM images of SiO2/4H-SiC interfaces reveal that abrupt interfaces are formed irrespective of the fabrication conditions. Transition regions around the interfaces reported by Zheleva et al. were not observed. Using EELS, profiles of the C/Si and O/Si ratios across an interface were measured. Our measurements did not reveal a C-rich region on the SiC side of the interface, which was reported by Zheleva et al.</jats:p
Chemical composition and biological properties of Synedrella nodiflora (L.) Gaertn: A comparative investigation of different extraction methods
No full textSynedrella nodiflora (L.) Gaertn. (Asteraceae), is a weed with ethnomedicinal uses. To extend scientific information on this species, we evaluated the effects of different extraction procedures (maceration, Soxhlet, sonication and homogenizer-assisted extraction (HAE)) using methanol as solvent, on the chemical composition and biological potential. The chemical profiles of the extracts were identified using a chromatographic (UHPLC-HRMS) technique. The antioxidant and enzyme inhibitory activities of the studied extracts were determined. The extract obtained by Soxhlet technique showed a higher level of total phenolic (TPC) and flavonoid content (TFC) and was a superior source of antioxidant compounds. The macerated extract was the most potent inhibitor of cholinesterases and α-glucosidase, whereas the highest activity against tyrosinase was observed in the order of sonication > Soxhlet > HAE > maceration. A modest activity was observed against α-amylase for all the extracts. Multivariate analysis showed that the bioactive compounds recovery and the biological activities of S. nodiflora were mostly dependent on the nature of the extraction technique used. In conclusion, S. nodiflora extracts showed good biological potential and data massed from this study could serve as a scientific baseline for further investigation in order to exploit its potential for designing novel bio-products with therapeutic applications
Mathematical modeling of the heat transfer during pyrolysis process used for end-of-life tires treatment
No full textFrom small-scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques
No full textThe genus Primula holds great importance as a source of traditional remedies in various folk medicine systems. In the present study, we investigated the chemical composition and biological properties of different extracts (ethyl acetate, ethanol, ethanol/water, and water) of aerial parts and rhizomes of Primula vulgaris. To determine the chemical profile, the extracts were analyzed using ultrahigh performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) technique and flavonoids were a major group in this profile. The antioxidant capacity was demonstrated by in vitro chemical tests and in general the ethanol/water extract was found to be the most potent. Enzyme inhibition was studied against various enzymes and ethanol and ethanol/water extracts were more active than others. To assess the anti-inflammatory potential of the extracts at the molecular level, human dermal fibroblasts (HDF) were treated with lipopolysaccharide (LPS). In vitro experiments showed that the levels of nuclear factor kappa B (NFKB), receptor for advanced glycation endproducts (RAGE), activator protein-1 (AP-1), interleukin 6 (IL-6), interleukin 17 (IL-17) and tumor necrosis factor (TNF)-alpha were significantly reduced after treatment with the tested extracts. In addition, the extracts showed an inhibitory effect on the enzymes collagenase, elastase, and hyaluronidase, which are involved in the inflammatory process and destabilization of the extracellular matrix (ECM). P. vulgaris has been observed to modulate matrix metalloproteinase (MMP) synthesis by decreasing the concentration of cellular reactive oxygen species (ROS) during LPS-induced inflammation. This study also examined the molecular binding and dynamic behavior of various enzymes and proteins associated with skin and infections using ligands derived from the tested extracts. Simulations with AutoDock Vina V1.1.2 and GROMACS 2023.1 showed that isoquercetin in particular showed superior performance in interactions with hyaluronidase. These findings are important for the development of potential therapeutic strategies for skin health and infection control. In summary, P. vulgaris can be considered as an important source of natural bioactive compounds for the development of effective health-promoting applications in nutraceuticals, pharmaceuticals, and cosmetics
Metodyka kształcenia przygotowującego przyszły personel medyczny do pracy z dziećmi i dorosłymi ze specjalnymi potrzebami
No full textChildren and adults with special needs are members of our society and take their place in it. They develop themselves and live among us. Share their lives with friends, neighbors and relatives. The methodology of training in health care aims to reveal and outline the system of training of future medical specialists to work with children and adults with special needs in the high school. The study presents the process and the conditions under which the methodology is a factor in the system of training of the specialists to work with these individuals. Presented "Individual healthcare plan" contains valuable information for needy children and adults with special needs care.Dzieci i dorośli ze specjalnymi potrzebami są pełnoprawnymi członkami naszego społeczeństwa. Rozwijają się i żyją między nami. Dzielą swoje życie z przyjaciółmi, sąsiadami i bliskimi. Artykuł ma na celu przedstawianie zarysu systemu kształcenia przygotowującego przyszły personel medyczny do pracy z osobami ze specjalnymi potrzebami. Prezentowany "Indywidualny plan opieki zdrowotnej" zawiera cenne informacje dla dzieci i dorosłych ze specjalnymi potrzebami
Metodyka kształcenia przygotowującego przyszły personel medyczny do pracy z dziećmi i dorosłymi ze specjalnymi potrzebami
No full textChildren and adults with special needs are members of our society and take their place in it. They develop themselves and live among us. Share their lives with friends, neighbors and relatives. The methodology of training in health care aims to reveal and outline the system of training of future medical specialists to work with children and adults with special needs in the high school. The study presents the process and the conditions under which the methodology is a factor in the system of training of the specialists to work with these individuals. Presented "Individual healthcare plan" contains valuable information for needy children and adults with special needs care.Dzieci i dorośli ze specjalnymi potrzebami są pełnoprawnymi członkami naszego społeczeństwa. Rozwijają się i żyją między nami. Dzielą swoje życie z przyjaciółmi, sąsiadami i bliskimi. Artykuł ma na celu przedstawianie zarysu systemu kształcenia przygotowującego przyszły personel medyczny do pracy z osobami ze specjalnymi potrzebami. Prezentowany "Indywidualny plan opieki zdrowotnej" zawiera cenne informacje dla dzieci i dorosłych ze specjalnymi potrzebami
Metodyka kształcenia przygotowującego przyszły personel medyczny do pracy z dziećmi i dorosłymi ze specjalnymi potrzebami
No full textChildren and adults with special needs are members of our society and take their place in it. They develop themselves and live among us. Share their lives with friends, neighbors and relatives. The methodology of training in health care aims to reveal and outline the system of training of future medical specialists to work with children and adults with special needs in the high school. The study presents the process and the conditions under which the methodology is a factor in the system of training of the specialists to work with these individuals. Presented "Individual healthcare plan" contains valuable information for needy children and adults with special needs care.Dzieci i dorośli ze specjalnymi potrzebami są pełnoprawnymi członkami naszego społeczeństwa. Rozwijają się i żyją między nami. Dzielą swoje życie z przyjaciółmi, sąsiadami i bliskimi. Artykuł ma na celu przedstawianie zarysu systemu kształcenia przygotowującego przyszły personel medyczny do pracy z osobami ze specjalnymi potrzebami. Prezentowany "Indywidualny plan opieki zdrowotnej" zawiera cenne informacje dla dzieci i dorosłych ze specjalnymi potrzebami
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