15,544 research outputs found
Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis
No full textOBJECTIVE: To test the hypothesis that gene-gene interaction of the renin-angiotensin system is associated with an effect on the extent of coronary atherosclerosis. SETTING AND RESULTS: A cohort of 1162 patients with coronary artery disease were genotyped for genetic polymorphisms in the renin-angiotensin system. Patients carrying the D allele of the angiotensin I converting enzyme (ACE) gene had greater coronary extent scores (defined as the number of coronary segments with 5% to 75% stenosis) than those not carrying this allele (p = 0.006 in non-parametric analysis and p = 0.019 in parametric analysis). This association remained significant after adjusting for age, body mass index, hypertension, and diabetes, which were also significantly associated with coronary extent scores. There was a significant interaction (p = 0.033) between genotypes of ACE and angiotensin II type 1 receptor (AGTR1). The association between the ACE gene D allele and increased coronary extent scores was significant (p = 0.008 in non-parametric and p = 0.027 in parametric analysis) in those carrying the +1166 C allele of the AGTR1 gene, but was absent in those not carrying the AGTR1 gene +1166 C allele. CONCLUSION: These findings suggest that variation in the ACE and AGTR1 genes and their interaction may not only contribute to susceptibility of coronary artery disease as previously found but also modify the disease process, thus contributing to interindividual differences in severity of the disease
(Simpson-Abelson <i>et al</i>.).
No full text<p>Transcript expression levels of the indicated genes in tongues isolated from the indicated mice 5 days after induction of oropharyngeal candidiasis. Increase over Sham-infected mice is indicated as follows:</p><p>*2-4-fold,</p><p>** 5–10 fold,</p><p>*** 10–50 fold,</p><p>**** > 100-fold</p><p>(Simpson-Abelson <i>et al</i>.).</p
Assessing waterlogging controls I: hydrologic model
No full textH. J. Morel-Seytoux, A. R. Simpson, and R. A. Younghttp://cedb.asce.org/cgi/WWWdisplay.cgi?3859
Letter from the Business Editor to I. S. Simpson
No full textLetter from the Business Editor, possibly B. R. Colson, to I. S. Simpson. The one-page typewritten note is dated 29 November 1912
Brief Investigatory Detentions: A Critique of R. v. Simpson
No full textIn this article, the author examines the brief investigative detention power created by the Ontario Court of Appeal in R. v. Simpson and challenges both the Court\u27s reasoning and the way in which the decision has been followed in other Canadian jurisdictions. The common law power to detain an individual, based upon prominent U.S. and British case law, is inconsistent with the previous Supreme Court jurisprudence on police powers. The author demonstrates this by analyzing several cases involving police powers and joins the list of commentators who have urged the country\u27s highest court to re-examine the Simpson doctrine. The author also argues that there has been a tendency for U.S. courts to grant increased discretion to the police even when such powers are unwarranted. There is a real possibility of a similar accretion of police powers in Canada. Moreover, the American experience also indicates that members of minority groups are frequently subjected to the rigours of brief investigative detention, often only because of their ethnic identity. Recent studies show that the same trend exists in Canada, serving to challenge democratic and egalitarian values that the Charter is designed to protect. The solution, according to the author, lies not with the Courts, but with Parliament taking the opportunity to define the extent and limits of brief investigative detentions
Half-Baked Humeanism
No full textToby Handfield has advanced a subtle form of dispositionalism that purports to reconcile the concept of causal powers with broadly Humean convictions by dissolving the requirement for objectively modal relations between powers and their manifestations. He suggests we should identify manifestations with certain types of causal processes, and identify powers with properties that are parts of their structures. The modal features of causal powers can then be explained in terms of internal relations between a power and the property of being a certain type of causal process, but these relations are supervenient and do not add anything to the basic ontology. In this way, causal powers may be ‘connected’ to their manifestations without admitting objectively modal relations. I disagree with this characterisation of causal powers and its identification of manifestations with types of causal processes: I question the assumption that causal processes can be isolated in quantum physics in the way Handfield requires and confront Humean dispositionalism with the problem of individuating powers in an entangled world
Kanter Revisited: Gender, Power and (In)visibility
No full textThis paper revisits Kanter's (1977) seminal work Men and Women of the Corporation, rereading her account of numerical advantage and disadvantage through a poststructuralist lens which exposes hidden dimensions of gendered power. This lens is captured in the ‘(In)visibility Vortex’ (Lewis and Simpson, 2010) which highlights struggles and tensions around the norm through processes of preservation and concealment within the norm as well as dynamics of revealing, exposure and disappearance as features of the margins. The study draws on developments in feminist theorizing, specially around visibility, invisibility and power, to facilitate this rereading. In so doing, the author demonstrate that while Kanter retreated from explanations based on the gendering of organizations or from recognition of gendered power, these dynamics can be identified in her text. The authors suggest that rereading classic texts can surface dimensions of organizations that have contemporary significance and can inform future research
Multiobjective optimization of water distribution systems accounting for economic cost, hydraulic reliability, and greenhouse gas emissions
No full textKey Points
Three‐objective WDS optimization considering cost, reliability and GHGs
Shape of solution space formed by the objectives is a U‐shaped curve
Location of Pareto front in the solution space and its practical implications
Wenyan Wu, Holger R. Maier, and Angus R. Simpso
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
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