109,521 research outputs found

    The 1961 Kampong Bukit Ho Swee fire and the making of modern Singapore

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    By 1970, Singapore’s urban landscape was dominated by high-rise blocks of planned public housing built by the People’s Action Party government, signifying the establishment of a high modernist nation-state. A decade earlier, the margins of the City had been dominated by kampongs, home to semi-autonomous communities of low-income Chinese families which freely built, and rebuilt, unauthorised wooden houses. This change was not merely one of housing but belied a more fundamental realignment of state-society relations in the 1960s. Relocated in Housing and Development Board flats, urban kampong families were progressively integrated into the social fabric of the emergent nation-state. This study examines the pivotal role of an event, the great Kampong Bukit Ho Swee fire of 1961, in bringing about this transformation. The redevelopment of the fire site in the aftermath of the calamity brought to completion the British colonial regime’s ‘emergency’ programmes of resettling urban kampong dwellers in planned accommodation, in particular, of building emergency public housing on the sites of major fires in the 1950s. The PAP’s far greater political resolve, and the timing of and state of emergency occasioned by the scale of the 1961 disaster, enabled the government to rehouse the Bukit Ho Swee fire victims in emergency housing in record time. This in turn provided the HDB with a strategic platform for clearing other kampongs and for transforming their residents into model citizens of the nation-state. The 1961 fire’s symbolic usefulness extended into the 1980s and beyond, in sanctioning the PAP’s new housing redevelopment schemes. The official account of the inferno has also become politically useful for the government of today for disciplining a new generation of Singaporeans against taking the nation’s progress for granted. Against these exalted claims of the fire’s role in the Singapore Story, this study also examines the degree of actual change and continuity in the social and economic lives of the people of Bukit Ho Swee after the inferno. In some crucial ways, the residents continued to occupy a marginal place in society while pondering, too, over the unresolved question of the cause of the fire. These continuities of everyday life reflect the ambivalence with which the citizenry regarded the high modernist state in contemporary Singapore

    Study of Ho-doped Bi2Te3 topological insulator thin films

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    This publication arises from research funded by the John Fell Oxford University Press (OUP) Research Fund and the Research Complex at Harwell is acknowledged for their hospitality. This work was supported by a DARPA MESO project (No. N66001-11-1-4105). S.E.H. was supported by the VPGE (Stanford University). L.C.M. and A.A.B. acknowledge partial financial support from EPSRC (UK) through a Doctoral Training Award. Diamond Light Source is acknowledged for beamtime on I10 (proposal SI10207).Breaking time-reversal symmetry through magnetic doping of topological insulators has been identified as a key strategy for unlocking exotic physical states. Here, we report the growth of Bi2Te3 thin films doped with the highest magnetic moment element Ho. Diffraction studies demonstrate high quality films for up to 21% Ho incorporation. Superconducting quantum interference device magnetometry reveals paramagnetism down to 2 K with an effective magnetic moment of ∼5 μB/Ho. Angle-resolved photoemission spectroscopy shows that the topological surface state remains intact with Ho doping, consistent with the material's paramagnetic state. The large saturation moment achieved makes these films useful for incorporation into heterostructures, whereby magnetic order can be introduced via interfacial coupling.Peer reviewe

    HO-1 deficiency leads to poor bacterial clearance <i>in vivo</i> and <i>in vitro</i>.

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    Panel A: MRSA CFU levels in HO-1+/+ and HO-1-/- mice. HO-1+/+ and HO-1-/- mice infected intrapleurally with 5x106 CFU of MRSA were euthanized at indicated time points post infection. Lungs, pleural fluid (PF) and peripheral blood (PB) harvested was minced, plated on to Muller Hinton agar plates and CFU of MRSA was determined as discussed under material methods. Data presented is Mean ±SD of six mice at each time point in each strain. ND = None detected. Panel B: MRSA CFU levels in HO-1+/+ and HO-1-/- PMCs. HO-1+/+ PMCs were infected with MRSA (MOI 1:10) either in presence of CoPP or ZnPP; simultaneously HO-1-/- PMCs were infected with MRSA (MOI 1:10) either in presence of CORM2 or Biliverdin. Cultures were harvested after 24 hours and plated on Muller Hinton agar plates with 1:10, 1:100 and 1:1000 dilutions and CFU of MRSA was determined by counting next day. Data are means ±SD of 3 independent experiments. Statistical significance *p5 MRSA incubated for 3h. The MRSA colonies were determined after 24h and expressed as MRSA-CFU recovered compared with control media treated cultures. Statistical significance $p#p<0.001 significant change between pUNO-TLR9-HA vector transfected and control vector transfected cells.</p

    FROM PHILOSOPHY TO HO CHI MINH'S IDEOLOGY

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    Abstract: The article points out that Ho Chi Minh is a typical philosopher whose core is political philosophy, thereby clarifying Ho Chi Minh’s ideology and practicing Ho Chi Minh’s ideology in Vietnam. Keywords: Philosophy, ideology, Ho Chi Minh. Title: FROM PHILOSOPHY TO HO CHI MINH’S IDEOLOGY Author: Dr. Nguyen Thi Hong Hai International Journal of Social Science and Humanities Research ISSN 2348-3156 (Print), ISSN 2348-3164 (online) Vol. 11, Issue 2, April 2023 - June 2023 Page No: 121-126 Research Publish Journals Website: www.researchpublish.com Published Date: 25-April-2023 DOI: https://doi.org/10.5281/zenodo.7861846 Paper Download Link (Source) https://www.researchpublish.com/papers/from-philosophy-to-ho-chi-minhs-ideologyInternational Journal of Social Science and Humanities Research, ISSN 2348-3156 (Print), ISSN 2348-3164 (online), Research Publish Journals, Website: www.researchpublish.co

    Actuacions dirigides a augmentar l’interès i la participació per l’assignatura per part de l’alumnat

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    Treball final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes. Codi: SAP129. Curs acadèmic 2013-2014Aquest és un Treball Final de Màster que mostra un Projecte de Millora Educativa basat en la metodologia d’Investigació-Acció dut a terme per un alumne del màster en la seua estada en pràctiques a un institut. Els grups on s’intenta portar la millora són dos tercers d’ESO. La problemàtica detectada és la falta de participació i interès de l’alumnat cap a l’assignatura, en aquest cas concret Educació Plàstica i Visual. Una vegada detectada aquesta problemàtica es comencen a recopilar dades per verificar que això és cert. Quan queda palès, es busca bibliografia per tal de trobar l’arrel del problema i fer canvis en el funcionament de les sessions per tal d’augmentar tal interès i participació i així, també, millorar els resultats d’aprenentatge. A l’inici s’observa que l’alumnat no presta molta atenció, no participa molt en classe, gran part no porta el material de l’assignatura, alguns no entreguen les fitxes que els mana el professor i les qualificacions no són gaire bones. Per millorar això i recolzant-nos en la bibliografia especialitzada s’apliquen una sèrie de canvis que consisteixen en canviar l’actitud del professor per fer-la més propera i fer sentir l’alumne valorat (Bacete & Betoret, 1997) i implicar-lo en la classe, adaptar el temari a la seua realitat (experiències i vida quotidiana) (Aguilar & Dorantes, 2010), utilitzant mètodes de participació, ja siguen durant les classes explicatives (Bacete & Betoret, 1997) com en les activitats (Sanmarti, 2010), proposar una tasca per treballar de manera col·laborativa (Sanmarti, 2010) recolzant-nos en l’ús de les TIC (Calzadilla, 2002) (Casado, y otros, 2007) i qualificant-la, en un percentatge concret, mitjançant la coavaluació. Durant el procés del canvi les dades que es van recollint apunten a que les accions estan donant el seu fruit i la predisposició dels alumnes cap a l’assignatura està canviant. En les observacions finals notem que tot l’alumnat ha realitzat la tasca i només un no l’ha passat amb èxit. Cosa que ve a demostrar que les accions han tingut un èxit elevat tenint en compte els objectius marcats però que podem millorar, ja que algun aspecte ha empitjorat, sobretot a l’hora de mantindre l’ordre de la classe. L’actitud de l’alumnat al llarg de les sessions en les que hem establert les millores ha virat cap on nosaltres ens havíem proposat, hem fet que els alumnes participen més en l’assignatura, s’interessen més per aquesta i realitzen les tasques. A més, per la manera de treballar escollida els resultats d’aprenentatge són millors ja que els grups eren heterogenis i, per tant, les qualificacions augmenten. Tot i això han sorgit noves situacions que calen millorar com el control de la classe en alguns moments, el recull de les dades de la coavaluació, el funcionament del treball en grup i també la recollida de dades de l’observació ja que, tot i que en general hem notat millores, com hem fet tants canvis resulta difícil detectar quins han donat millores més rellevants i quins no o inclús aquells que poden haver perjudicat. Per a això hem fet una proposta de millora encaminada a seguir amb les estratègies que han funcionat i corregir les que no ho han fet com esperàvem com són controlar més les intervencions amb torns de paraula i regles establertes entre tots, avaluar per part del professor o, en cas que siga coavaluació, fer-ho mitjançant alguna aplicació informàtica que facilite el recull de dades, aprofundir en les “regles” del treball en grup i fer nous qüestionaris més encaminats a observar el resultat de les noves accions

    HO-1 and HIF-1α are expressed in the peri-infarct region of the ischemic mouse brain.

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    (A) Representative image of the TTC stained regions (a, contralateral region; b, peri-infarct region; c, infarct region) in a mouse subjected to 2 h ischemia and 24 h reperfusion (I/R) (n = 3 per group). (B) DAB staining observed as brown color in the peri-infarct region (b) in wild-type (WT) and HO-1+/- mice. Scale bars = 20 μm. (C) Expression of target proteins was determined in brain tissues using western blot analysis, and their levels were quantified (n = 5 per group). **P D) WT and HO-1+/- mice were subjected to I/R, and the brain sections (a, contralateral region; b, peri-infarct region; c, infarct region) were stained with the indicated antibodies (n = 4 per group). Images are representative from three individual tissues.</p

    HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.

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    Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression. In many diseases including murine malaria, HO-1 induction produces protective anti-inflammatory effects, but observations from patients suggest these may be limited to a narrow range of HO-1 induction, prompting us to investigate the role of HO-1 in malaria infection. In 307 Gambian children with either severe or uncomplicated P. falciparum malaria, we characterized the associations of HMOX1 promoter polymorphisms, HMOX1 mRNA inducibility, HO-1 protein levels in leucocytes (flow cytometry), and plasma (ELISA) with disease severity. The (GT)(n) repeat polymorphism in the HMOX1 promoter was associated with HMOX1 mRNA expression in white blood cells in vitro, and with severe disease and death, while high HO-1 levels were associated with severe disease. Neutrophils were the main HO-1-expressing cells in peripheral blood, and HMOX1 mRNA expression was upregulated by heme-moieties of lysed erythrocytes. We provide mechanistic evidence that induction of HMOX1 expression in neutrophils potentiates the respiratory burst, and propose this may be part of the causal pathway explaining the association between short (GT)(n) repeats and increased disease severity in malaria and other critical illnesses. Our findings suggest a genetic predisposition to higher levels of HO-1 is associated with severe illness, and enhances the neutrophil burst leading to oxidative damage of endothelial cells. These add important information to the discussion about possible therapeutic manipulation of HO-1 in critically ill patients

    Annex 1. Prova inicial gramatical pronoms "en" i "ho"

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    Prova inicial gramatical sobre el pronom "en" i el pronom "ho" amb activitats distractores. Annex 1 a la seqüència didàctica sobre "en" i sobre "ho"

    Annex 3. Prova inicial oral pronoms "en" i "ho"

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    Prova inicial oral sobre el pronom "en" i el pronom "ho" amb activitats distractores. Annex 3 a la seqüència didàctica sobre "en" i sobre "ho"

    Annex 2. Prova inicial d'escriptura pronoms "en" i "ho"

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    Prova inicial d'escriptura sobre el pronom "en" i el pronom "ho" amb activitats distractores. Annex 2 a la seqüència didàctica sobre "en" i sobre "ho"
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