5,413 research outputs found
SHEER hos bondböna - dess molekylära funktion och potentiella roll i stresstolerans
No full textVicia faba, faba bean, is an ancient crop, which has seen a resurgence in popularity in Finland in recent years. Faba bean has a high protein content, high yield and positive effects on soil nutrients and pollinator communities, but is attacked by several pathogens, of which Botrytis spp. is the most damaging, sometimes destroying the whole yield. A lack of reference genome has slowed down breeding efforts, although this was solved last year with the publication of a faba bean reference genome. The Stress induced HEmE Receptor (SHEER) family of proteins have been shown to play a role in several cellular processes of animals and plants. SHEER is one of these proteins, having been shown to bind heme, be involved in stress resistance and pathogen resistance and possibly autophagy in the model organism Arabidopsis thaliana. The observations of the protein function in A. thaliana makes it an interesting target for research also in faba bean, a species in which SHEER has not yet been studied. SHEER is highly conserved in eukaryotes and can therefore be expected to have similar functional roles in A. thaliana and faba bean.
In this thesis, SHEER from the cultivars ‘Disco’ and ‘Tiffany’ is isolated and sequenced to determine the genomic and coding sequence of the gene. The heme binding ability of recombinant SHEER in vitro is demonstrated and the ability of the predicted heme binding and C-terminal domain of faba bean SHEER is shown to functionally complement sheer knockout A. thaliana plants. Furthermore, a phylogenetic tree was made of SHEER family homologs from 22 eukaryotic species, showing a split early in eukaryotic development between the SHEER homologs and the rest of the SHEER family homologs. The results presented in this thesis provide a good foundation for understanding SHEER function in faba bean, but more research is needed to determine further molecular functions, besides heme binding, and the role of the protein in physiological processes, such as pathogen resistance.Vicia faba, bondböna, är en antik gröda som har sett ett uppsving i popularitet i Finland under de senaste åren. Bondböna innehåller en hög andel protein, ger en stor skörd och har positiva effekter för pollinerare och på jordmånens ämnessammansättning. Bondböna drabbas dock av flertalet sjukdomar, varav chokladfläcksjuka orsakad av Botrytis spp. är den mest skadliga. Denna sjukdom kan till och med förstöra hela skörden på en åker. Bristen på ett referensgenom hos bondböna har försvårat förädlingen, vilket löstes förra året av att ett referensgenom för bondböna publicerades. Stress induced HEmE Receptor (SHEER) familjen av proteiner har visats spela en roll i flertalet cellulära processer hos både djur och växter. SHEER är ett av dessa proteiner och har visats binda hem, vara involverat i stresstolerans och patogenresistens, och möjligtvis vara involverat i autofagi i modellorganismen Arabidopsis thaliana. Observationerna av dessa funktioner i A. thaliana gör SHEER till ett intressant mål för forskning även i bondböna, en art där SHEER inte har undersökts tidigare.
I denna avhandling isolerar och sekvenserar jag SHEER från bondbönekultivaren ’Disco’ och ’Tiffany’ för att avgöra genens sekvens. Jag demonstrerar SHEERs förmåga att binda hem in vitro, och förmågan hos bondbönans SHEERs hembindande och C-terminala domäner att funktionellt komplettera sheer knockout A. thaliana jämförbart med vildtyp påvisas. Dessutom konstruerar jag ett fylogram med homologer till SHEER-proteinerna från 22 eukaryota arter, vilket indikerar en splittring av SHEER-homologerna från resten av SHEER-proteinernas homologer tidigt i eukaryoternas evolution. Resultaten som presenteras i denna avhandling utgör en lovande grund för att förstå funktionen av SHEER i bondböna. Mera forskning behövs dock inom detta område för att upptäcka ytterligare molekylära funktioner, förutom bindning av hem, hos SHEER och proteinets roll i fysiologiska processer, såsom patogenresistens, hos bondböna
Sistema Cucina "Sheer"
No full textSheer è una cucina a scomparsa brevettata prodotta da Sheer, marchio di Gatto cucine. Sheer è uno dei prodotti più innovativi apparsi negli ultimi anni nel settore delle cucine, per la bellezza della forma, per le soluzioni tecnologiche adottate, per i materiali avanzati utilizzati. Il suo successo è testimoniato dalle numerosissime recensioni ed esposizioni nelle più importanti mostre mondiali.
Sheer è costituita da un’isola circolare e da un mobile-parete. L’isola è composta da due semisfere di 148 cm. di diametro, che possono assumere la doppia configurazione aperta e chiusa. Quella inferiore è in carbonio o in acciaio. Quella superiore è in metacrilato traslucido con funzione di cappa aspirante e lampadario. Il mobile- parete autoportante, progettato nelle tre misure 180, 210 e 240 cm, rivestito in carbonio o in legno, è composto da un sistema espositivo con mensole-maniglie in alluminio, integrato ad un blocco posteriore per elettrodomestici ad inserimento laterale e cassettoni di contenimento. Si chiude con una tenda a rullo elettrificata
The erasure of race and racism
No full textWith the advent in the UK of a new Labour government in 1997 and the publication of the Macpherson report in 1999, public debate over race and racism was reactivated after a long period when such concerns had remained dormant. In this article, I shall draw upon an ethnographic study of one university in the UK over a ten year period (Pilkington, 2011a). Here I shall focus on the early part of that period, predominantly 1999-2003 when arguably issues relating to race and racism were at their height. I examine how Midshire University responded in turn to the Commission for Racial Equality’s (CRE’s) leadership challenge; the government’s strategies for higher education relating to widening participation and equal opportunities; and the race relations legislation. The story is not a happy one, with the institution constantly subsuming race under a more general agenda and in the process failing to address the specificities of race. Midshire University is unlikely to be the only university to do this. For universities in the UK are typically characterised by the ‘sheer weight of whiteness’ which blinds senior managers and academics to racial inequalities in their midst
Student Struggle for Soviet Jewry, with Rabbi Charles Sheer
No full textRecording of a weekly radio program by Jerry Goodman
called "Russia Reports" that aired on the radio station WEVD. Rabbi
Charles Sheer, Jewish Chaplain at Columbia University, member of the
board of The Student Struggle for Soviet Jewry talks about the
beginnings, the functions and the methods of the SSSJ.Digital recordingDigital finding aid
Theōn hemerai: astrology, the planetary week, and the cult of the seven planets in the Graeco-Roman world
No full textSheer Being and Thought
No full textI wrote earlier on the difference between the Pippinian and Houlgatian interpretations of Hegel’s Logic. In the current piece, I want to elaborate a bit more on Stephen Houlgate’s take on what he calls ‘sheer being’. It will still be extremely exploratory, without delving into the detail of Hegel’s own text, let alone into the secondary literature on the beginning of the Logic (apart from Houlgate, important work in this area is offered by Robert Pippin, Dieter Henrich, Rolf-Peter Horstmann, and more recently Pirmin Stekeler-Weithofer in his massive 3-volume commentary on the Logic). The piece is chiefly critical of a particular, sophisticated and influential reading of the Logic, and doesn’t make propositions on how a positive reading of the Logic might look like.
These are just some more critical reflections on what I take to be an ultimately unsuccessful way of approaching Hegel’s Logic, one though that seems very influential and intuitively plausible. I am increasingly suspicious of their attempts to defend ontological readings of Hegel’s Being Logic, such as we can find in the work of Houlgate (but also many others). Below I shall comment in turn on various passages I quote from a recent essay by Houlgate (Houlgate 2018) and elaborate on some of the central arguments
“Dichotomies in Silk: Sheer and Opaque”
No full textSince my days as a student of design, I was interested in fiber as a means to express myself creatively, influenced largely by Junichi Arai’s innovative works in the 1980s. As an artist, I emphasize the material itself and how it takes on shape in the same manner as that of a sculptor. It is in my character as an artist and designer to play with diverse materials and experiment with an array of techniques that can be applied to them. Illustrated by slides, I would like to share my creative exploration using silk fabric and recent technical improvements in surface design processes.
Having had the opportunity to explore a huge array of polyester fabrics in the 1990s, I experimented with the thermoplastic characteristics of polyester using various shaping processes and heat. This gave me the foundation to open the potential of silk when I later worked with Isao Negishi, a chemical engineer who perfected the process of silk cloque in combination with traditional Japanese paste-resist dying techniques of kata-zome (stenciled) and tsutsu-gaki (hand painted).
Sheer silk fabric may be either screen printed or hand-painted with paste-resist, then immersed in chemicals. This causes the exposed areas to crimp and condense into opaque sections, puckering the fabric. The resulting design is much like a bas-relief pattern set against the reserved areas of the original sheer fabric. A stronger chemical solution (or thinner reserve paste) yields greater shrinkage. The possibilities in achieving expressive textural patterns are endless and silk fiber, being natural, behaves like a living entity with its subtle nuances seen in each piece
Cover to Be Unveiled: How Meaning Is Revealed with Sheer Veils in Paintings by Lucas Cranach the Elder
No full textWhile scholars have questioned the meaning of Lucas Cranach the Elder’s sheer veils when associated with sensual nude figures, research about sheer veils adorning women in a religious context in his paintings has not yet been developed. Through a primarily iconographical approach, I explore who dons each type of veil, and when, to better understand why the same sheer veil is worn differently by various individuals and what that could mean relative to Cranach’s body of work. These veils exhibit artistic prowess, but analysis of their placement on individual figures also reveals how Cranach’s repeated use of sheer veils in his paintings trains the eye on underlying messages, unlocking meanings of these works for Cranach and his patrons and broader themes present in sixteenth century visual culture. My paper initiates this important discussion about how sheer veils – often overlooked in Cranach’s works – are used in both religious and secular contexts
Sheer Poison? Wittgenstein’s Philosophy of Religion
No full textAnscombe once said to Anthony Kenny that “On the topic of religion, Wittgenstein is sheer poison”. This paper offers an assessment of that view. I take it that Anscombe meant that Wittgenstein was a bad influence rather than that his views were necessarily false, although she seems to have been uncertain about what exactly his views were. In “Paganism, Superstition and Philosophy”, she identifies five ideas that make up “a certain current in philosophy which has a strong historical connection with Wittgenstein”. I identify some of the sources of these ideas, in Wittgenstein’s writing and in work by some of his followers, and consider what Anscombe’s objections to them might have been. I also look at whether we should think of these ideas as belonging either to Wittgenstein’s philosophy of religion or to his personal beliefs. This will involve some consideration of how far we can, or should try to, separate the personal from the philosophical. So far as he held objectionable views about religion, I argue that these ought to be considered personal rather than philosophical
Sheer Poison? Wittgenstein’s Philosophy of Religion
No full textAnscombe once said to Anthony Kenny that “On the topic of religion, Wittgenstein is sheer poison”. This paper offers an assessment of that view. I take it that Anscombe meant that Wittgenstein was a bad influence rather than that his views were necessarily false, although she seems to have been uncertain about what exactly his views were. In “Paganism, Superstition and Philosophy”, she identifies five ideas that make up “a certain current in philosophy which has a strong historical connection with Wittgenstein”. I identify some of the sources of these ideas, in Wittgenstein’s writing and in work by some of his followers, and consider what Anscombe’s objections to them might have been. I also look at whether we should think of these ideas as belonging either to Wittgenstein’s philosophy of religion or to his personal beliefs. This will involve some consideration of how far we can, or should try to, separate the personal from the philosophical. So far as he held objectionable views about religion, I argue that these ought to be considered personal rather than philosophical
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