123 research outputs found
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6
No full textEffector caspases-3, -6 and -7 are responsible for producing the morphological features associated with apoptosis, such as DNA fragmentation. The present study demonstrates that a member of a novel series of pyrrolo-1,5-benzoxazepines, PBOX-6, induces apoptosis in MCF-7 cells, which lack caspase-3. Apoptosis was accompanied by DNA fragmentation and the activation of caspase-7, but not caspases-3 and -6. Inhibition of caspase-7 activity reduced the extent of apoptosis induced, indicating that activation of caspase-7 is involved in the mechanism by which PBOX-6 induces apoptosis in MCF-7 cells. This study suggests that caspase-3 is not necessarily essential for DNA fragmentation and the morphological changes associated with apoptosis. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved
Rick Bragg, 1997 Harry M. and Edel Ayers Lecture Series 1
No full textAuthor Rick Bragg was featured at the Harry M. and Edel Ayers Lecture Series held November 19, 1997 on the 11th floor of the Houston Cole Library at Jacksonville State University.https://digitalcommons.jsu.edu/lib_ac_histimg_1990/1381/thumbnail.jp
Rick Bragg, 1997 Harry M. and Edel Ayers Lecture Series 2
No full textAuthor Rick Bragg was featured at the Harry M. and Edel Ayers Lecture Series held November 19, 1997 on the 11th floor of the Houston Cole Library at Jacksonville State University. Shown Rick Bragg chats with Opal A. Lovett after giving his speech.https://digitalcommons.jsu.edu/lib_ac_histimg_1990/1382/thumbnail.jp
EDEL: ENEA dosemeter for eye lens
No full textSince the publication of International Commission on Radiological Protection statement in 2011 on tissue reaction, eye lens radiation protection played an important role in exposed personnel dosimetry. For this reason, the Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA) Individual Monitoring Service decided to study a prototype to fulfil specific requests (e.g. for survey in interventional department and intercomparisons). On the basis of such preliminary investigation, a new eye lens dosemeter was developed. The new dosemeter, named EDEL (ENEA Dosemeter for Eye Lens), was characterised in terms of Hp(3), the operational quantity related to eye lens monitoring. The investigation was performed experimentally and optimised using the Monte Carlo MCNP6 code. The new prototype was thought to fulfil two main requests: the reliability of the dosimetric data and the portability of the dosemeter itself. The new dosemeter will soon be supplied to the collaborating hospitals for workplace test measurements. © The Author 2015. Published by Oxford University Press. All rights reserved
Polyphony and the anxiety of influence in the fiction of Henry James
Get PDFJames's fiction, especially in the Middle Phase, centres
on the figure of the artist and is characterized by, the two
interrelated aspects which previous criticism has largely
overlooked: the Bakhtinian 'polyphonic' -creation of
'author-thinkers'; and the conflict between ephebes and
precursors, for which Harold-Bloom's concept of 'the-anxiety of
influence' is the most illuminating model. Polyphony is the
narrative mode, and influence is the intra-artistic, theme.
These, as the Introduction to the thesis makes clear, are
rehearsed in James's inaugural novel, Roderick Hudson. Rowland
Mallet is an author-thinker, and his failure is caused by
authorial limitations. His monologism -is impaired by his
mistaking empathy for the authorial sympathy. Likewise,
Hudson's failure does not arise from a mercurial temperament,
but from a polyphonic shortcoming: not possessing the power of
fiction to contain the fiction of power in, his mentor. And the
relationships among the three artists - Gloriani, Hudson and
Singleton - perfectly exemplify the Bloomian-theme. It is these
two concepts, polyphony and influence, which are the major
preoccupation in the Middle Phase; as, the works chosen
demonstrate. These are a novella, a novel, and a number of
short stories all of which have been unjustifiably neglected.
Chapter One, on The Aspern Papers, argues that Tina Bordereau,
far from being, the artless victim seen by many critics,
actually challenges and defeats the narrator by the very form
of her narrative. Her 'realist' discourse undermines his
language of 'romance', and shows up its internal unstability.
Chapter Two is an extensive study of the critical reception of
The Tragic Muse. The most common areas of critical attention
have been its contemporary topicality, its relation to previous
novels on similar themes, and the possible genealogy of Gabriel
Nash. Those have all missed the core of the work. - Chapter Three
demonstrates how polyphony and the anxiety of influence make
the novel what it really is. Influence arises from the
juxtaposition of, and the wrestling between, artistic ephebes
and their precursors (Nick and Nash,, Miriam and Madame Carre).
The dialogic quality defined by Bakhtin is crucial to the
proper, and even-handed, characterization of all, the conflicts
in the novel. And since most of James's tales in the eighties
and nineties -are about 'masters - and acolytes, the anxiety of
influence remains central. Chapter Four is a study of 'The
Author of Beltraffiol' and 'The Lesson of the Master'. Again the
characters' manipulations are a crucial focus in a way that
G6rard Genette's terminology helps to illuminate. The fact that
the ephebe is the author-thinker emphasizes the inextricability
of the Bakhtinian and the Bloomian in James. Just as
polyphony offers a different focus for explicating the poetics
of James's fiction; so the ephebal conflict provides the basis
for a fresh perception of James's own artistic struggle
Protein Synthesis and Turnover
No full textUpon completion of transcription, the newly synthesized messenger RNA (mRNA) translocates out of the nucleus and into the cytoplasm where it gets translated into functional proteins. Decoding the mRNA into an amino acid sequence requires the concerted action of both RNA molecules, including transfer RNAs (tRNAs) and ribosomal RNAs (rRNAS), as well as many cytoplasmic proteins. This chapter outlines the molecular events that underlie the translation of mRNA into protein, highlighting the mechanisms that ensure high fidelity of these events. This chapter also discusses how newly synthesized proteins are targeted to their correct intracellular location, as well as the quality control mechanisms in place that ensure protein integrity inside the cell
Newly Qualified Irish Primary School Teachers’ Experiences and Understandings of Reinforcement and Punishment
No full textThe Irish education system has had many considerable changes within the past two decades. Initial teacher education has considerably lengthened in duration. Behaviour management models utilised within the education system have also shifted, from punitive towards reinforcement-based procedures. There has been a significant amount of research regarding the preparation provided by ‘Initial Teacher Education’ (ITE) programmes in the Irish context. Much of this research highlighted findings regarding how underprepared teachers are in the area of behaviour management. Interestingly, however, there has been little research on preparedness since the ITE programmes have recently lengthened in duration. Therefore, this qualitative research aimed to answer the question: What are the experiences and understandings of Irish newly qualified primary school teachers (NQTs) in the area of punishment and reinforcement within the context of behaviour management? Four semi-structured interviews with newly qualified teachers were conducted. Thematic analysis of transcripts indicated four key themes: ‘Learning of behaviour management’, ‘Reinforcement’, ‘Punishment’, and ‘Establishment of behaviour management’. The findings indicate, though provided with various learning opportunities, newly qualified teachers lack in their understanding of the terms reinforcement and punishment, despite clear uses of both in the classrooms. The NQTs had a clearer concept of the term reinforcement, in comparative to that of punishment. Although participants were largely unaware of the definition of punishment, and often evidently disapproving of its use, there were clear uses of punishment procedures by NQTs in the findings of this study. This study indicated the need to scrutinise education in the area of behaviour management at both initial teacher education and newly qualified teacher levels. Further studies investigating the impact of varying methods of preparation for effective behaviour management may be beneficial. Further exploration of the causal links between NQT self-efficacy and the selection of reinforcement or punishment is also recommended
Regulation of Gene Expression: Basic Mechanisms
No full textThe study of genes and the mechanism whereby the information they hold is converted into proteins and enzymes, hormones, and intracellular signaling molecules is the realm of molecular biology. Except for the erythrocyte, all cells in the body have the same DNA complement. One of the most fascinating aspects of this work is the study of the mechanisms that control differential gene expression, both in time and in place, and the consequences if these control mechanisms are disrupted.The goal of this chapter is to introduce the basic concepts involved in regulation of protein-coding genes and how these processes are involved in the causation of human disease. The basic mechanism of gene regulation will be described first, followed by a discussion of a specific gene regulation system to highlight various aspects of the basic mechanism. The chapter will end with a discussion of various ways in which the gene regulatory apparatus can be adapted to suit the needs of different tissues and situations.<br/
Siegfried In The Interpretations Of The German Film Directors Of The Early 20th – Early 21st Century (Fritz Lang's "The Nibelungs" And Uli Edel`S "Ring Of The Nibelungs")
No full textFilm experts and art historians studied German cinema in detail, however, movies based on “The Song of the Nibelungs” as well as on the German and Scandinavian heroic epic have not yet been investigated by means of modern interdisciplinary approaches. The author pays attention to Siegfried, one of the most important heroes of the German and Scandinavian epic, according to Fritz Lang's (1890 – 1976) and Uli Edel`s (1947) interpretations, divided by almost a century (1924 and 2004). The author analyzes various means of expression: visuality, scenery, actor's performance, credits/dialogues. As far as the Lang's movie is concerned, he concludes that one can interpret the figure of Sigfried on two levels of interpretation. The first is the visual one which includes the actor's performance and the work of support staff (e.g. dress makers, set dressers). It describes him as an extraordinary strong hero. The second one is the semantic level which is formed of credits and music. It creates a myth about Siegfried as the national hero. In Edel's movie, the dialogues between heroes and actor's performance are used as the main means of expression. In Lang’s interpretation, Siegfried is described as the neo-romantic superhero, the person possessing a special force. Uli Edel’s Siegfried obtains dialectic nature – he is the prince, the king, and he is also the commoner; courageous soldier, dragon slayer, and obedient vassal, servant; son of Christian parents, pagan's stepson. The author assumes that Fritz Lang and Uli Edel reacted to inquiries of the time. In the 1920s, Germany suffered a difficult period between the two World Wars, the German people were oppressed by military reparations. Powerful Siegfried, as the national hero and embodiment of the German people, was urged to remind Germans of their great heroic past, to return their self-confidence to them. In our era of globalization and multiculturalism, the idea of association, peaceful co-existence of various ideas and religions was embodied in Siegfried.</jats:p
Fawcett, Edgar, 1885 August 15
No full textCopy extant? No record of it in Edel bindersPrivate, Anderson Galleries (NY), 3-4 September 1928: "Autograph Collection of a Late American Author" (#543
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