20,778 research outputs found
Epidemiological Studies on Multiple Risk Factors for Myopia in Taiwan: Gene-Environment Interaction
No full textAnalysis of EGF signaling in healthy aging promotion in caenorhabditis elegans
No full textThe increase in longevity expectancy has been a focused issue goal of much current aging research. Many genes have been noted to modulate longevity of simple model systems, acting through distinct mechanisms. However, in principle, promotion of healthy aging of individual tissues can be accomplished without a major impact on the longevity endpoint. As such, healthspan-only genes may have been missed by genetic screens for longevity. New screens for tissue–specific betterment of aging phenotypes were anticipated to reveal a class of genes that might be manipulated for tissue-specific anti-aging outcomes. We identified two novel healthspan regulators, called HPA-1 and HPA-2 (for the high performance in old age locomotory phenotypes that their disruption confers) that delay age-associated locomotory decline when they are knocked down by RNAi or by genetic deletion. Surprisingly, hpa-1 and hpa-2 do not regulate healthspan through canonical recognized longevity pathways. Instead, the structure of HPA proteins implicated a novel function of EGF signaling in anti–aging protection, and my genetic studies supported this mechanism. Activated EGF signaling confers a positive effect on multiple aging phenotypes, acting through the downstream branch of the EGF pathway involving PLCanalysis defined the temporal and spatial benefits from EGF signaling. EGF/lin-3 ligand is expressed into late life and acts throughout life to influence healthy aging. lin-3 alternative slice variants, lin-3S and lin-3XL show healthspan promotion. Muscle and neuron are the most potent tissue for EGFR signaling on healthspan enhancement. I also identified global and tissue-specific modulators of healthy aging in the EGF pathway and identified candidate calcium-sensitive transducers of the anti-aging function of EGF signaling. Recent data in vertebrates suggest that EGF signaling might contribute to long-term maintenance. Thus, EGF signaling may exert a conserved impact on healthy aging and might be a plausible reagent for anti-aging therapies.Ph. D.Includes bibliographical referencesIncludes vitaby Shih-Hung Y
An Integrated Modified Smith Predictor with PID Controller for Integrator Plus Deadtime Processes
No full textAutomated robotic assembly using a vibratory work table : optimal tuning of vibrators based on the Taguchi method
Full text linkThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1992.Includes bibliographical references (leaves 66-70).by Shih-Hung Li.M.S
Progressive learning of endpoint feedback systems with model uncertainty and sensor noise
Full text linkThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1996.Includes bibliographical references (leaves 141-146).by Shih-Hung Li.Ph.D
Documents of Ling-shih Hung (令史弘)
Full text linkEtsin-gol MSS. (居延漢簡) found at Kharakhoto amount to even ten thousand and mostly are fragmentary. It would be very difficult to put them in order. Here the writer wishes to suggest one approach to this purpose. He has collected as many documents as possible concerning Ling-shih Hung (令史弘). He believes that it is possible to make several reasonable groups of documents by thus centering them in such and such individuals
Uca (Gelasimus) jocelynae Shih, Naruse & Ng 2010
No full textUca (Gelasimus) jocelynae Shih, Naruse & Ng, 2010 (Fig. 3E, F) Uca (Gelasimus) jocelynae Shih, Naruse & Ng, 2010a: 51, figs. 2–4 [type locality: Penghu, Taiwan]; Shih 2012b: 64, figs. 90– 93; Toyota & Seki 2014: 221, 4 unnumbered figs. (see Shih et al. 2010a for list of citation of synonyms) Uca jocelynae — Shih 2012b: 64, figs. 90–93; Fujita & Uyeno 2015: 98, fig. 3D–F. Material examined. (See Shih et al. 2010a for specimens from Taiwan [including Penghu] and the Ryukyus) Dongsha Island: 1 ♂ (16.2 mm) (NCHUZOOL 14735), 1 ♂ (14.1 mm) (NCHUZOOL 14736), 3 Sep. 2011; 2 ♂♂ (14.9, 15.0 mm) (NCHUZOOL 14728), 19 Nov. 2011; 1 ♂ (18.1 mm) (NCHUZOOL 14729), 23 Mar. 2012; 1 ♂ (11.8 mm) (NCHUZOOL 14730), 24 Mar. 2012; 1 ♂ (17.5 mm) (NCHUZOOL 14734), 26 May 2012. Distribution. Widely distributed on the western Pacific islands (Ryukyus, Taiwan [including Penghu and Dongsha], Guam, the Philippines, Sulawesi, Papua New Guinea, and Vanuatu. Remarks. Uca jocelynae is found in the western part (west to Vanuatu) of the western Pacific, in contrast to the range of its sister species U. neocultrimana (east to Fiji) (Shih et al. 2010a: fig. 1). See Remarks under U. borealis for the morphological comparison of the three species of the U. vocans complex.Published as part of Shih, Hsi-Te, Lee, Jung-Hsiang, Ho, Ping-Ho, Liu, Hung-Chang, Wang, Chia-Hsiang, Suzuki, Hiroshi & Teng, Shao-Jyun, 2016, Species diversity of fiddler crabs, genus Uca Leach, 1814 (Crustacea: Ocypodidae), from Taiwan and adjacent islands, with notes on the Japanese species, pp. 57-82 in Zootaxa 4083 (1) on page 64, DOI: 10.11646/zootaxa.4083.1.3, http://zenodo.org/record/105088
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