108 research outputs found
Ethyl 4-[3-(2-methylbenzoyl)thioureido]benzoate
No full textThe molecular conformation of the title compound, C18H18N2O3S, is stabilized by an intramolecular N—H ... O hydrogen bond. The crystal packing shows centrosymmetric dimers connected by N—H ... S hydrogen bonds. The terminal ethoxy substituents are statistically disordered [occupancy ratio 0.527 (5):0.473 (5)]
3,3'-Dibutanoyl-1,1'-(o-phenylene)dithiourea
No full textThe molecular conformation of the title compound, C16H22N4O2S2, is stabilized by two intramolecular N—H ... O hydrogen bonds. The crystal packing shows N—H ... O and N—H ... S hydrogen bonds
Corrigendum to “Promising electrochemical study of titanate based anodes in direct carbon fuel cell using walnut and almond shells biochar fuel” [J. Power Sources 434 (2019) 126679](S0378775319306500)(10.1016/j.jpowsour.2019.05.085)
No full text© 2019 Elsevier B.V. The authors regret that the family name of author Asia Rafique was wrongly added as ‘Asia Iftikhar’ in the original article, the corrected name is “Asia Rafique”. The authors would like to apologise for any inconvenience caused
Synthesis, characterization and crystal structure of ethyl 4-(3-chloro benzamido)benzoate
No full textThe title compound was efficiently synthesized in two steps starting from esterification of 4-aminobenzoic acid followed by amidation with 3-chlorobenzoyl chloride in dry tetrahydrofuran. The structure was confirmed by spectroscopic data and elemental analysis. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with Z = 2 and unit cell dimensions a = 5.2941(15) Å, b = 8.157(2) Å, c = 16.238(4) Å, α = 82.682(6)°, β = 84.481(6)°, γ = 80.100(6)° and V = 683.2(3) Å3
Islam: Extremism and Moderation
No full textIslam has, for many years now, been torn between radical fundamentalist groups and the more intellectually moderate groups. With both groups claiming to follow the true Islam, an individual may have a difficult time in practicing one’s faith.
The ambition of this essay will be to investigate some of the major differences between the movements, more specifically the Wahhabi/Salafi movement practiced in Saudi Arabia and the more moderate approach emphasized by numerous Islamic Scholars. Grappling with these issues in my own search for the authentic Islam, this essay will provide a view of both sides with an attempt to justify the moderate position over the strict, literalist one. The intention is to show why the moderate intellectual position is more rooted in Islamic principles and values than the monotonous fanatic position. Due to the many sects, some with more extreme positions like the Khawarij alongside the more rational such as the Mu’tazilites, I decided it would be an enlightening task to break down both sides and challenge the history of both.Peer reviewedstudent peer-reviewed journal articlefinal article publishe
More Than One Path?
No full textIn the minds of many Muslims and non-Muslims the idea of salvation in Islam is quite simple: only Muslims have a chance of attaining paradise and anyone who does not profess to be a Muslim is destined for eternal doom. The ambition of this essay is to argue that from the Islamic point of view, non-Muslims do indeed have a chance of attaining God’s mercy and being saved. This will be argued by taking a look at how the Qur’an accepts diversity, verses in the Qur’an regarding other faiths, along with an explanation and commentary on these verses from some of the most learned scholars on the Qur’an. Also, this essay will look at various Prophetic precedents in Islamic history on this issue.student peer reviewed journal articlefinal article publishe
Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches
No full textMuhammad Tahir Aqeel,1 Nisar ur-Rahman,1 Arif-ullah Khan,2 Zaman Ashraf,3 Muhammad Latif,4 Hummera Rafique,5 Usman Rasheed1 1Department of Pharmacy, COMSATS Institute of Information Technology Abbottabad, Abbottabad, Pakistan; 2Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan; 3Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan; 4College of Medicine, Centre for Genetics and Inherited Diseases (CGID), Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia; 5Department of Chemistry, University of Gujrat, Gujrat, Pakistan Background: Hyperlipidemia is a worth-mentioning risk factor in quickly expanding cardiovascular diseases, including myocardial infarction and, furthermore, in stroke. Methods: The present work describes the synthesis of phenolic derivatives 4a–e and 6a–c with the aim of developing antihyperlipidemic agents. The structures of the synthesized compounds were confirmed by spectroscopic data. The in silico docking studies were performed against human 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase enzyme (PDB ID: 1HWK), and it was observed that compounds 4a and 6a exhibited maximum binding affinity with target protein having binding energies −8.3 and −7.9 kcal, respectively. Results: Compound 4a interacts with amino acids Val805 with distance 1.89 Å and Met656, Thr558, and Glu559 with bonding distances 2.96, 2.70, and 2.20 Å, respectively. The in vivo antihyperlipidemic activity results revealed that compound 4a indicated minimum weight increment, ie, 20% compared with 35% weight increment with standard drug atorvastatin during 6 weeks of treatment. Moreover, increment in high-density lipoprotein cholesterol and decrease in total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were more prominent in case of 4a compared to atorvastatin with P<0.05. The synthesized compounds were nontoxic and well tolerated because none of the mice were found to suffer from any kind of morbidity and death during 6 weeks of dosing. Conclusion: Based on our pharmacological evaluation, we may propose that compound 4a may act as a lead structure for the design and development of more potent antihyperlipidemic drugs. Keywords: phenolic derivatives, synthesis, antihyperlipidemic, in silico docking, HMG CoA reductase, atorvastati
Methyl 3,5-dibromo-4-methylbenzoate
No full textIn the title compound, C9H8Br2O2, the molecule is essentially planar with an r.m.s. deviation of 0.0652&#8197;&#197; from the mean plane through all non-H atoms and a dihedral angle of 7.1&#8197;(2)&#176; between the benzene ring plane and the carboxylate substituent. In the crystal structure, weak C&#8212;H...Br hydrogen bonds and weak intermolecular O...Br contacts [3.095&#8197;(2)&#8197;&#197;], link adjacent molecules into layers parallel to (102). Additional weak intermolecular C&#8212;H...O hydrogen bond interactions stack the layers above and below the molecular plane and down the a axis
Methyl 4-methylbenzoate
No full textThe structure of the title compound, C9H10O2, is related to that of 4-methylphenyl 4-methylbenzoate and ethylene di-4-methylbenzoate showing similar bond parameters. The molecule is planar, the dihedral angle between the aromatic ring and the –COOMe group being 0.95 (6)°. The cystal structure exhibits intermolecular C—H...O contacts that link molecules into infinite chains extended in the [001] direction
- …
