2,565 research outputs found
The future of community research: a conversation with Alison Hulme, Alan Bradshaw and Adam Arvidsson
Full text linkTo better understand the state of community research in other disciplines, and to consider how the contexts of contemporary market societies are changing both com- munities, and knowledge making in respect of communities
Mix and Match: Mono-substituted Hydrocarbon Diastereomer Combinations Reveal Stapled Peptides with High Structural Fidelity
No full textModified peptides such as stapled peptides, which replicate the structure of α-helical protein segments, represent a potential therapeutic advance. However, the 3D solution structure of these stapled peptides is rarely explored beyond the acquisition of CD data to quantify bulk peptide helicity; the detailed backbone structure which underlies this is typically undefined. Diastereomeric stapled peptides based on helical sections of three proteins (αSyn, Cks1 and CK1α) were generated; their overall helicity was quantified by CD; and the most helical peptide from each series was selected for structural analysis. Solution-phase models for the optimised peptides were generated using NMR-derived restraints and a modified CHARMM22 force field. Comparing these models with PDB structures allowed deviation between the stapled peptides and critical helical regions to be evaluated. These studies demonstrate that CD alone is not sufficient to assess the structural fidelity of a stapled peptide.
## File format information ##
* ".lip" - "All-Hydrogen Lipid Parameter File". This format is plain text.
* ".pdb" - "Protein Data Bank". This format is plain text
Introduction Iron rice bowls and plastic money: the push and pull of consumerism’s rise in capitalist/communist China
No full textAs the plane takes off the girl next to me gently rustles the bag nestled between her feet, eager to explore its contents. She looks about 20, but it is difficult to tell. She wears some fashionably distressed jeans and a sports top. This is the flight from Shanghai to Kunming, the provincial capital of rural Yunnan province in Southwest China. I am the only non-Chinese face on board. Once we have reached our cruising height the girl leans down and pulls the bag onto her lap, opening it and taking out a blue Adidas zip-up top, a pale pink T-shirt with the words ‘cool life’ scrawled on it in glittery silver, and a Hello Kitty pencil case. She holds each of the things in front of her, examining them from different angles, turning them over in her hands, and feeling their insides and edges. Her face is at times tense, as if fearing potential regret at her own error of judgement or taste in buying them, and at times serene. Finally, seeming pleased with her purchases, she turns to me and smiles, asking where I am from – “Meiguo?” she says. I reply that I am not American, but English. “Ah Yinguo! David Beckham, Big Ben, Red Bus,” she reels off gleefully, citing the global signs that have in recent years become those most attributed to the UK
Listening Locally:A Study Into The Impact Of Local Radio
Full text linkThis report looks at the social impact of local radio in Northampton in terms of how it influences social resilience and individual well-being. It was conducted from January to November 2021and involved an online questionnaire and follow-up interviews. The author is Dr Alison Hulme who conducted the research in conjunction with NLive radio and the University of Northampton. It was funded by the University of Northampton’s Business Ideas and Innovation Grant (BIIG)
Listening Locally:A Study Into The Impact Of Local Radio
Full text linkThis report looks at the social impact of local radio in Northampton in terms of how it influences social resilience and individual well-being. It was conducted from January to November 2021and involved an online questionnaire and follow-up interviews. The author is Dr Alison Hulme who conducted the research in conjunction with NLive radio and the University of Northampton. It was funded by the University of Northampton’s Business Ideas and Innovation Grant (BIIG)
Listening Locally:A Study Into The Impact Of Local Radio
Full text linkThis report looks at the social impact of local radio in Northampton in terms of how it influences social resilience and individual well-being. It was conducted from January to November 2021and involved an online questionnaire and follow-up interviews. The author is Dr Alison Hulme who conducted the research in conjunction with NLive radio and the University of Northampton. It was funded by the University of Northampton’s Business Ideas and Innovation Grant (BIIG)
Development and Application of Desorption Electrospray Ionization Mass Spectrometry for Historical Dye Analysis
No full textPrimary data files for the data presented in upcoming publication E. Sandström, C. Vettorazzo, C.L. Mackay, L.G. Troalen and A.N. Hulme. 'Development and Application of Desorption Electrospray Ionization Mass Spectrometry for Historical Dye Analysis.' Analytical Chemistry (in submission)
From ‘make do and mend’ to ‘your country needs you to spend’: Constructing the Consumer in late-modernity
No full textChemBioChem 2016 - Bisebromoamide files
No full textSystematic alanine-scanning of the linear peptide bisebromoamide (BBA), isolated from a marine cyanobacterium, is enabled by targeting the solid phase peptide synthesis of thiazole analogues. The synthetic Tz-BBA analogues have comparable cytotoxicity (nM) to bisebromoamide and cellular morphology assays indicate that they target the actin cytoskeleton. Pathway inhibition in human colon tumour (HCT-116) cells has been explored using reverse phase protein array (RPPA) analysis, which shows a dose-dependent response of IRS-1 expression. Alanine-scanning reveals a structural dependence to the cytotoxicity, actin-targeting and pathway inhibition, and allows a new readily-synthesised lead to be proposed
'Hulme and the Nightmare Scenario':Reading Race, Collecting Cultures - The Roving Reader Files
Full text linkThe Ahmed Iqbal Ullah Race Relations Resource Centre is an open access University of Manchester facility. The Roving Reader Files category of blog posts is produced by Alison Newby (under the pseudonym The Roving Reader) in collaboration with Hannah Niblett (Collections Access Officer). The Roving Reader Files are designed as public engagement materials, the intention being to introduce research skills and terminology to the general user/reader in an entertaining yet informative manner by revealing hidden stories, making unusual connections and sharing insights into using the Centre's collection for research. The blog post "Hulme and the Nightmare Scenario" introduces the Hulme Study Collection (held in the Centre’s archive) in order to give a flavour of how one of the worst UK urban planning disasters of the mid-to-late twentieth century affected the lived experience of one of Manchester’s most deprived communities. Rare, unpublished City Council documentation is juxtaposed with the published hopes for the future recorded by local residents in Hulme Views. Self Portraits, revealing the spirit, strength, camaraderie and humour surviving in the multi-ethnic Hulme community despite tremendous tensions and difficulties
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