4,135 research outputs found
PCR-mediated recombination can lead to artificial chimera formation, which may pose as BCR-ABL1 compound mutations
No full textPowerpoint presentationWendy T Parker, Stuart R Phillis, David T Yeung, Timothy P. Hughes, Hamish S Scott and Susan Branfor
Investigation of an anisotropic tortuosity in a Biot model of ultrasonic propagation in cancellous bone
No full textThe modeling of ultrasonic propagation in cancellous bone is relevant to the study of clinical bone assessment. Historical experiments revealed the importance of both the viscous effects of bone marrow and the anisotropy of the porous microstructure. Of those propagation models previously applied to cancellous bone, Biot's theory incorporates viscosity, but has only been applied in isotropic form, while Schoenberg's anisotropic model does not include viscosity. In this paper we present an approach that incorporates the merits of both models, by utilizing the tortuosity, a key parameter describing pore architecture. An angle-dependent tortuosity for a layered structure is used in Biot's theory to generate the “Stratified Biot Model” for cancellous bone, which is compared with published bone data. While the Stratified Biot model was inferior to Schoenberg's model for slow wave velocity prediction, the proposed model improved agreement fast wave velocity at high propagation angles, particularly when sorted for porosity. An attempt was made to improve the fast wave agreement at low angles by introducing an angle-dependent Young's Modulus, which, while improving the agreement of predicted fast wave velocity at low angles, degraded agreement at high angles. In this paper the utility of the tortuosity in characterizing the architecture of cancellous bone is highlighte
Our Savior and King: Theology proper in 1 Timothy
No full textIn this dissertation the author seeks to present a holistic theology proper (hereafter, simply "theology") for the first epistle to Timothy, with special regard to the letter's doxologies (King) and divine title, Savior. Chapter 1 identifies the problem, includes a history of research, and describes the method and procedure of the dissertation. The method of inquiry consists of determining the meaning and function of the letter's theology. Thus, the author seeks to understand the background and character of 1 Timothy's theology, while also wishing to discern why the author of 1 Timothy chose to emphasize these peculiar theological themes.
Chapter 2 explores the meaning and function of the theological descriptions found in the doxologies of 1 Timothy 1:17 and 6:15-16. By thorough comparison to Greco-Roman, early Jewish, and OT literature, the author suggests a basically OT-informed view of God. The doxologies depict God as the only Sovereign who rules over all. The writer then determines that the doxologies function as a support and encouragement for Timothy to heed Paul's charge. This conclusion is largely based on the positioning of the doxologies and the macrostructure of the letter.
Chapter 3 examines the meaning and function of the divine epithet Savior. After comparing this term to its occurrences in Greco-Roman, early Jewish, and OT literature, the author again favors an OT background for Savior. This term depicts God as one who mercifully and indiscriminately reconciles sinners who trust in Christ. While also recognizing other functions, the author suggests that God as Savior may have been aimed at the primary implied reader, Timothy, as well. Accordingly, the idea of Savior informs and strengthens Timothy, so that he might continue to labor in presenting the life-giving gospel of God.
Chapter 4 considers every remaining theological description in 1 Timothy, as well as themes that significantly relate to the letter's theology, such as Christology. The author suggests that the entire theology of 1 Timothy either coheres with or supports the predominant ideas of God as King and Savior.
Chapter 5 summarizes the dissertation's findings and concludes with suggested implications for NT studies
Estimation of critical and viscous frequencies for Biot theory in cancellous bone
No full textThe use of Biot theory for modelling ultrasonic wave propagation in porous media involves the definition of a ‘critical frequency’ above which both fast and slow compressional waves will, in principle, propagate. Critical frequencies have been evaluated for healthy and osteoporotic cancellous bone filled with water or marrow, using data from the literature. The range of pore sizes in bone gives rise to a critical frequency band rather than a single critical frequency, the mean of which is lower for osteoporotic bone than normal bone. However, the critical frequency is a theoretical concept and previous researchers considered a more realistic ‘viscous frequency’ above which both fast and slow waves may be experimentally observed. Viscous frequencies in bone are found to be several orders of magnitude greater than calculated critical frequencies. Whereas two waves may well be observed at all ultrasonic frequencies for water-filled cancellous bone at 20 °C, it is probable megahertz frequencies would be needed for observation of two waves in vivo
A web-based screening tool for near-port air quality assessments
No full textAuthor(s): Isakov, Vlad; Barzyk, Timothy M; Smith, Elizabeth R; Arunachalam, Saravanan; Naess, Brian; Venkatram, Akul
Roma, magistra mundi. Itineraria culturae medievalis. Mélanges offerts au Père L.E. Boyle à l\u27occasion de son 75e anniversaire
No full textR. James Long (with Timothy B. Noone) is a contributing author, Fishacre and Rufus on the Metaphysics of Light: Two Unedited Texts , Volume 2, pp. 517-548
A molecular assessment of species boundaries and phylogenetic affinities in Mogurnda (Eleotridae): a case study of cryptic biodiversity in the Australian freshwater fishes
No full textAs the driest inhabitable continent, it comes as no surprise that Australia has comparatively few species of freshwater-dependent fishes compared with land masses of similar size and latitudinal coverage. In addition to relatively low rainfall and few permanent waterbodies, a range of other climatic, geological, physical, and biogeographical factors are generally offered up, to account for the low species count in a country otherwise regarded as mega-biodiverse. Here, we challenge this traditional view by hypothesising that Australia’s lack of freshwater fishes largely reflects a dearth of detailed taxonomic activity. Using both allozyme and mtDNA markers, we undertook a molecular assessment on the Australian purple-spotted gudgeons (Mogurnda), recently subjected to a taxonomic revision that saw a three-fold increase in the number of described species. In addition to demonstrating additional, species-level biodiversity within M. adspersa, our genetic data revealed discordant patterns of mitochondrial and nuclear genetic affinities among populations in several species, plus a sister relationship between the two central Australian species. We discuss the broader implications of such cryptic biodiversity for the Australian freshwater fish fauna; most notable among these is our prediction that only 50% of species have been described.Mark Adams, Timothy J. Page, David A. Hurwood, and Jane M. Hughe
Supplemental Material - Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study
No full textSupplementary Material for Decline in Lung Function From Mid-to Late-Life With Central Arterial Stiffness: The Atherosclerosis Risk in Communities Study by Kennedy M. Peter, James R. Pike, John S. Preisser, Anna M. Kucharska-Newton, Michelle L. Meyer, Maria C. Mirabelli, Priya Palta, Timothy Hughes, Kunihiro Matsushita, Yifei Lu, and Gerardo Heiss in Angiology.</p
Detection of low level nilotinib or dasatinib resistant BCR-ABL mutations by mass spectrometry in CML patients who fail Imatinib is highly predivtive of their subsequent clonal expansion when treated with the drug for which their mutation confers resistance
No full textWendy T Parker, Musei Ho, Rebecca M Lawrence, Darryl L Irwin, Hamish S Scott, Timothy Hughes and Susan Branfordhttp://ash.confex.com/ash/2010/webprogram/Paper29762.htm
Reading Barcodes from Digital Imagery
No full textThis document was prepared for Dr. John Loomis as part of the written PhD. candidacy exam by Timothy R. Tuinstra. This report provides a look at the automatic detection and decoding of barcodes found within imagery. Such techniques could conceivably be used in the retail, manufacturing, inventory and travel industries as well as others. A general description of barcodes is included as well as a review of some of the techniques used to automatically locate barcodes within larger images containing additional objects. The author will also present some results from implementing a variant of these techniques. I
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