8,557 research outputs found
Progress and outlook in studying the substrate specificities of PARPs and related enzymes
No full textDespite decades of research on ADP-ribosyltransferases (ARTs) from the poly(ADP-ribose) polymerase (PARP) family, one key aspect of these enzymes - their substrate specificity - has remained unclear. Here, we briefly discuss the history of this area and, more extensively, the recent breakthroughs, including the identification of protein serine residues as a major substrate of PARP1 and PARP2 in human cells and of cysteine and tyrosine as potential targets of specific PARPs. On the molecular level, the modification of serine residues requires a composite active site formed by PARP1 or PARP2 together with a specificity-determining factor, HPF1; this represents a new paradigm not only for PARPs but generally for post-translational modification (PTM) catalysis. Additionally, we discuss the identification of DNA as a substrate of PARP1, PARP2 and PARP3, and some bacterial ARTs and the discovery of noncanonical RNA capping by several PARP family members. Together, these recent findings shed new light on PARP-mediated catalysis and caution to 'expect the unexpected' when it comes to further potential substrates
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies.
No full textNutritive value of winter wheat for broiler chickens
No full textThe nutritive value of Australian winter wheat varieties for broiler chickens was assessed in a series of conventional energy balance studies each of 7-days duration. Across all samples, the mean and standard deviation for apparent metabolisable energy (AME, MJ/kg dry matter) were 14.29±0.36 (n=25) and ranged from 13.68 to 15.02. For individual varieties, means and standard deviations were 14.80±0.03 for Declic (n=2), 14.31±0.33 for Lawson (n=16), 13.97±0.34 for More (n=4) and 14.20±0.09 for Paterson (n=3). In conclusion, winter wheats were consistently high in AME but, nevertheless, were responsive to endo-4,4-xylanase added to the diet. Uplift in AME of wheat due to enzyme supplementation averaged 0.7 MJ/kg (4.9%) and ranged from 0.22 MJ/kg (1.5%) to 1.13 MJ/kg (8.2%).R.J. Hughes, L. Acone, P. Zviedrans and M. Choc
Polarized electron Source for the Stanford Linear Accelerator
No full textAlguard MJ, Ehrlich RD, Hughes VW, et al. Polarized electron Source for the Stanford Linear Accelerator. In: Proc. IXth Int. Conf. High Energy Acc. 1974: 309-313
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Goal-orientated Functional Rehabilitation using Electrical Stimulation and Iterative Learning Control for Motor Recovery in the Upper Extremity Post-Stroke.
No full textThere is increasing evidence that electrical stimulation (ES) combined with task specific training is effective in the recovery of upper extremity dysfunction following stroke. The aim of this study is to develop a rehabilitation system that delivers precisely controlled levels of stimulation to the shoulder, elbow and wrist during goal-oriented activity which utilises everyday real objects. Iterative learning control (ILC) is used to mediate the ES and updates the stimulation signal applied to each muscle group based on the error between the ideal and actual movement in the previous attempt. The control system applies the minimum amount of stimulation required, maximising voluntary effort with a view to facilitating success at each given task. Markerless motion tracking is provided via a Microsoft Kinect, with hand and wrist data measured by an electrogoniometer. Preliminary results show that ES mediated by ILC has successfully facilitated movement across the shoulder, elbow and wrist of chronic stroke patients. Overall, joint error has reduced for all participants with the mean error across all joints showing reductions for all participants. Furthermore, there was a significant reduction in extrinsic support necessary for each task. The system is described and initial intervention data are reported
Applied Theatre: International Case Studies and Challenges for Practice (second edition) edited by Monica Prendergast and Juliana Saxton and Critical Perspectives on Applied Theory edited by Jenny Hughes and Helen Nicholson
No full text"Applied Theatre: International Case Studies and Challenges for Practice (Second edition) edited. by Monica Prendergast and Juliana SaxtonCritical Perspectives on Applied Theory edited by Jenny Hughes and Helen Nicholson." Contemporary Theatre Review, 27(1), pp. 129–13
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