9,744 research outputs found
Induction of mitotic arrest and apoptosis in human prostate cancer PC-3 cells by evodiamine
No full textAssociations between urinary phthalate monoesters and thyroid hormones in pregnant women.
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Pandemic influenza H1N1 vaccination intention: psychosocial determinants and implications from a national survey, Taiwan.
No full textAbstract
BACKGROUND:
Vaccination has been recommended as an effective way to protect people from severe illness during influenza pandemics; however, little is known about the acceptability and psychosocial determinants of intention to receive vaccination against pandemic influenza A/H1N1 (pH1N1).
METHODS:
A national computer-assisted telephone interview survey using random digit dialing was conducted during 28-30 October 2009 among residents of Taiwan aged ≥15 years.
RESULTS:
Of the 1079 participants interviewed, 70.1% reported intention to receive pH1N1 vaccination. Multivariate logistic regression analysis showed that participants who perceived pH1N1 in Taiwan to be much more severe than that in other countries [adjusted odds ratio (AOR)=1.94; 95% confidence interval (CI)=1.05-3.60], who agreed (AOR=2.44; 95% CI=1.30-4.58) or strongly agreed (AOR=2.53; 95% CI=1.38-4.65) that contracting pH1N1 would have a great impact on their daily life, who perceived pH1N1 vaccination to be very effective in preventing pH1N1 (AOR=2.64; 95% CI=1.61-4.33) and who considered receiving vaccination not very difficult (AOR=8.97; 95% CI=6.05-13.29) or not at all difficult (AOR=30.72; 95% CI=19.24-49.04) were more inclined towards getting vaccinated against pH1N1.
CONCLUSION:
These specific and modifiable health beliefs have practical implications for prevention and policy making, and highlight the importance of minimizing perceived barriers while convincing the public of the seriousness of the disease and effectiveness of vaccination when promoting vaccination programmes
A PC parallel port button box provides millisecond response time accuracy under Linux
Full text linkFor psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus
Modulation of Anti-Adhesion Molecule Muc-1 Is Associated with Arctiin- Induced Growth Inhibition of Pc-3 Cells
No full textBACKGROUND. Lignans have been reported to possess anti-tumor activity in various cancer cells. However, their anticancer effects in human prostate cancer have not been well established. Here, we examine the effect of arctiin, a lignan compound, on growth regulation in prostate cancer PC- 3 cells. We postulated that arctiin modulates the attachment/detachment of PC-3 cells and we investigated the role of arctiin on MUC-1 expression. METHODS. The effect of arctiin on PC-3 cell growth was examined using an MTT assay method and cell number was calculated by means of a standard regression line. The expressions of MUC-1 and integrins alpha(2), alpha(5) , and beta(1) were detected using FACScan flow cytometric analysis. Levels of MUC-1 mRNA were determined using reverse transcriptase PCR (RT-PCR). RESULTS . Treatment of PC-3 cells with arctiin decreased the cell number in a concentration and time-dependent manner in serum -containing condition. Arctiin preferentially induced cell detachment, but did not have anti-proliferation or cytotoxic effects in PC-3 cells. The arctiin- induced effect was inhibited by cycloheximide, indicating that protein synthesis was required. FACScan flow cytometric analysis demonstrated that arctiin increased the expression of the anti-adhesion mucin MUC-1, but did not affect integrin expression in PC-3 cells. The arctiin-induced increase in MUC-1 protein expression was due to up-regulation of mRNA, as revealed by RT-PCR analysis. CONCLUSIONS. Arctiin significantly induces cell detachment and decreases the cell numbers via the up-regulation of MUC-1 mRNA and protein in PC-3 cells. (C) 2003 Wiley-Liss. Inc
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