110 research outputs found

    sj-docx-1-cll-10.1177_09636897241228031 – Supplemental material for Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

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    Supplemental material, sj-docx-1-cll-10.1177_09636897241228031 for Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice by Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang and Bingwei Sun in Cell Transplantation</p

    How many grid-forming converters do we need? a perspective from small signal stability and power grid strength

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    © 2024 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.Grid-forming (GFM) control has been considered a promising solution for accommodating large-scale power electronics converters into modern power grids thanks to its grid-friendly dynamics, in particular, voltage source behavior on the AC side. The voltage source behavior of GFM converters can provide voltage support for the power grid, and therefore enhance the power grid (voltage) strength. However, grid-following (GFL) converters can also perform constant AC voltage magnitude control by properly regulating their reactive current, which may also behave like a voltage source. Currently, it still remains unclear what are the essential differences between the voltage source behaviors of GFL and GFM converters, and which type of voltage source behavior can enhance the power grid strength. In this paper, we will demonstrate that only GFM converters can provide effective voltage source behavior and enhance the power grid strength in terms of small signal dynamics. Based on our analysis, we further study the problem of how to configure GFM converters in the grid and how many GFM converters we will need. We investigate how the capacity ratio between GFM and GFL converters affects the equivalent power grid strength and thus the small signal stability of the system. We give guidelines on how to choose this ratio to achieve a desired stability margin. We validate our analysis using high-fidelity simulations.This work was jointly supported by the National Key Research and Development Program (2023YFB2406600) and the National Natural Science Foundation of China (No. U2166204 and No. 51922094). (Corresponding author: Linbin Huang.) H. Xin, C. Liu, and Y. Wang are with the College of Electrical Engineering, Zhejiang University, Hangzhou, China. (Email: [email protected]) X. Chen is with the School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. E. Prieto-Araujo is with the Electrical Engineering Department, Technical University of Catalonia, 08034 Barcelona, Spain. L. Huang is with the Department of Information Technology and Electrical Engineering at ETH Z¨ urich, Switzerland. (Email: [email protected])Postprint (author's final draft

    Construction of a genetic linkage map in <i>Pyropia yezoensis</i> (Bangiales, Rhodophyta) and QTL analysis of several economic traits of blades

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    Pyropia yezoensis is an economically important seaweed but its molecular genetics is poorly understood. In the present study, we used a doubled haploid (DH) population that was established in our previous work to construct a genetic linkage map of P. yezoensis and analyze the quantitative trait loci (QTLs) of blades. The DH population was genotyped with fluorescent sequence-related amplified polymorphism (SRAP) markers. A chi-square test identified 301 loci with normal segregation (P ≥ 0.01) and 96 loci (24.18%) with low-level skewed segregation (0.001 ≤ P P. yezoensis.</div

    Molecular Mechanisms in Idiopathic Mitral Valve Chordae Tendineae Rupture: Insights from Transcriptome Analysis and Inflammation Evaluation

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    Qiuji Wang,1– 3,&ast; Lishan Zhong,1,2,&ast; Linbin Hua,1– 3 Shanwen Pang,1– 3 Yuxin Li,1,2 Zhaolong Zhang,1,2 Junfei Zhao,1,2 Huanlei Huang1– 3 1Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, People’s Republic of China; 2Guangdong Cardiovascular Institute, Guangzhou, 510030, People’s Republic of China; 3Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Huanlei Huang, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email [email protected] Junfei Zhao, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email [email protected]: This study investigates the molecular mechanisms and hub genes in idiopathic rupture of mitral valve chordae tendineae (iRCT).Methods: Histological changes were assessed via pathological staining, and transcriptome sequencing was performed on samples from 8 iRCT patients and 6 controls. Differentially expressed genes (DEGs), functional enrichment, PPI networks, and immune cell infiltration were analyzed. Hub gene expression was validated using RT-qPCR.Results: iRCT samples exhibited cell proliferation, disorganized collagen fibers, and elastin fiber rupture. Immunohistochemical analysis further confirmed that activated fibroblasts, macrophages, dendritic cells, and T cells were increased in iRCT samples compared to normal samples. Additionally, iRCT samples exhibited an increased content of collagen fibers and elastin fibers. Transcriptome analysis identified 208 DEGs (109 upregulated, 99 downregulated) linked to inflammation, immune activation, and extracellular matrix remodeling.Conclusion: iRCT involves ECM remodeling, inflammation, and immune dysregulation, with identified hub genes offering potential therapeutic targets.Keywords: mitral valve prolapse, chordae tendineae rupture, inflammation, immune response, transcriptome, bioinformatic

    Sequence-related amplified polymorphism primers used to detect DNA polymorphisms among parents and doubled haploid population of <i>Pyropia yezoensis</i>.

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    Sequence-related amplified polymorphism primers used to detect DNA polymorphisms among parents and doubled haploid population of Pyropia yezoensis.</p

    Promoting effects of aluminum addition on chlorophyll biosynthesis and growth of two cultured iron‐limited marine diatoms

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    Promoting effects of aluminum addition on chlorophyll biosynthesis and growth of two cultured iron‐limited marine diatoms Linbin Zhou CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China Marine Biogeochemistry Division GEOMAR Helmholtz Centre for Ocean Research Kiel Germany University of Chinese Academy of Sciences Beijing China https://orcid.org/0000-0001-7230-4116 Fengjie Liu Marine Biogeochemistry Division GEOMAR Helmholtz Centre for Ocean Research Kiel Germany Grantham Institute—Climate Change and the Environment, Department of Life Sciences Imperial College London London UK Eric P. Achterberg Marine Biogeochemistry Division GEOMAR Helmholtz Centre for Ocean Research Kiel Germany Anja Engel Marine Biogeochemistry Division GEOMAR Helmholtz Centre for Ocean Research Kiel Germany https://orcid.org/0000-0002-1042-1955 Peter G.C. Campbell Institut National de la Recherche Scientifique Centre Eau Terre Environnement Quebec Canada https://orcid.org/0000-0001-7160-4571 Claude Fortin Institut National de la Recherche Scientifique Centre Eau Terre Environnement Quebec Canada https://orcid.org/0000-0002-2479-1869 Liangmin Huang CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China University of Chinese Academy of Sciences Beijing China Yehui Tan CAS Key Laboratory of Tropical Marine Bio‐resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China University of Chinese Academy of Sciences Beijing China Abstract Aluminum (Al) may play a role in the ocean's capacity for absorbing atmospheric CO 2 via influencing carbon fixation, export, and sequestration. Aluminum fertilization, especially in iron (Fe)‐limited high‐nutrient, low‐chlorophyll ocean regions, has been proposed as a potential CO 2 removal strategy to mitigate global warming. However, how Al addition would influence the solubility and bioavailability of Fe as well as the physiology of Fe‐limited phytoplankton has not yet been examined. Here, we show that Al addition (20 and 100 nM) had little influence on the Fe solubility in surface seawater and decreased the Fe bio‐uptake by 11–22% in Fe‐limited diatom Thalassiosira weissflogii in Fe‐buffered media. On the other hand, the Al addition significantly increased the rate of chlorophyll biosynthesis by 45–60% for Fe‐limited T. weissflogii and 81–102% for Fe‐limited Thalassiosira pseudonana , as well as their cell size, cellular chlorophyll content, photosynthetic quantum efficiency ( F v / F m ) and growth rate. Under Fe‐sufficient conditions, the Al addition still led to an increased growth rate, though the beneficial effects of Al addition on chlorophyll biosynthesis were no longer apparent. These results suggest that Al may facilitate chlorophyll biosynthesis and benefit the photosynthetic efficiency and growth of Fe‐limited diatoms. We speculate that Al addition may enhance intracellular Fe use efficiency for chlorophyll biosynthesis by facilitating the superoxide‐mediated intracellular reduction of Fe(III) to Fe(II). Our study provides new evidence and support for the iron–aluminum hypothesis

    Information on the genetic linkage map of <i>Pyropia yezoensis</i> constructed with sequence-related amplified polymorphism markers based on a doubled haploid population.

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    Information on the genetic linkage map of Pyropia yezoensis constructed with sequence-related amplified polymorphism markers based on a doubled haploid population.</p

    Quantitative trait loci (QTLs) of five economic traits of gametophytic blades of <i>Pyropia yezoensis</i>.

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    Quantitative trait loci (QTLs) of five economic traits of gametophytic blades of Pyropia yezoensis.</p

    Information of segregation distortion regions (SDRs) on the genetic linkage map of <i>Pyropia yezoensis</i>.

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    Information of segregation distortion regions (SDRs) on the genetic linkage map of Pyropia yezoensis.</p
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