3,008 research outputs found
Frequencies and distribution of t-haplotype in the Southeast Asian house mouse (Mus musculus castaneus) in Taiwan.
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Dicentrine, an alpha-adrenoceptor antagonist with sodium and potassium channel blocking activities.
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Evaluation and Physical Therapy Intervention of Oral Feeding Difficulty in Preterm Infants-Literature Review.
No full textInvolvement of multiple DNA elements in iron-inducible transcription of the ap65-1 gene in the protozoan parasite Trichomonas vaginalis.
No full textMagnetic resonance imaging of seminal vesicle cyst associated with ipsilateral urinary anomalies.
No full textNon-invasive and transdermal measurement of blood uric acid level in human by electroporation and reverse iontophoresis
No full text[[abstract]]The aim of this study was to find out the optimum combination of electroporation (EP) and reverse iontophoresis (RI) on noninvasive and transdermal determination of blood uric acid level in humans. EP is the use of high-voltage electric pulse to create nano-channels on the stratum corneum, temporarily and reversibly. RI is the use of small current to facilitate both charged and uncharged molecule transportation across the skin. It is believed that the combination of these two techniques has additional benefits on the molecules' extraction across the human skin. In vitro studies using porcine skin and diffusion cell have indicated that the optimum mode for transdermal uric acid extraction is the combination of RI with symmetrical biphasic direct current (current density = 0.3 mA/cm(2); phase duration = 180 s) and EP with 10 pulses per second (voltage = 100 V/cm(2); pulse width = 1 ms). This optimum mode was applied to six human subjects. Uric acid was successfully extracted through the subjects' skin into the collection solution. A good correlation (r(2) = 0.88) between the subject's blood uric acid level and uric acid concentrations in collection solutions was observed. The results suggest that it may be possible to noninvasively and transdermally determine blood uric acid levels.[[note]]SC
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