201 research outputs found
Optimal procurement policy for cost conscious retailer
No full textManufacturers whose products primarily relay on expensive raw materials need to make well informed procurement decisions in order to reduce their production costs. Decision making is especially difficult when there is uncertainty about the raw material cost as well as the product demand. This research considers an optimum procurement and production planning problem under uncertainty. Basic raw material is a rare metal with a dynamically and stochastically changing price. The manufacturer has the dual sourcing option: buy from the spot market; or to sign long term contracts. Long term contracts can be signed only at the beginning of every year with a yearly duration. In addition, the contract price depends on the average spot price during some interval. We first consider a simplified version of the problem without long-term contract, and assume a base-stock procurement and inventory control policy. We model the problem as a Markov chain and present some numerical examples demonstrating the effect of various parameters on the optimum base-stock value. Then, we investigate a case with dual procurement option, and present our results.M.S.Includes bibliographical referencesby Sicong Ho
sj-doc-1-tag-10.1177_17562848221150306 – Supplemental material for Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy
No full textSupplemental material, sj-doc-1-tag-10.1177_17562848221150306 for Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy by Mian Chen, Junguo Chen, Jun Huang, Huashan Liu, Wuteng Cao, Shuangling Luo, Zhanzhen Liu, Huanxin Hu, Sicong Lai, Yujie Hou, Liang Kang and Liang Huang in Therapeutic Advances in Gastroenterology</p
sj-doc-1-tag-10.1177_17562848221117875 – Supplemental material for Clinical significance of adjuvant chemotherapy for pathological complete response rectal cancer patients with acellular mucin pools after neoadjuvant chemoradiotherapy
No full textSupplemental material, sj-doc-1-tag-10.1177_17562848221117875 for Clinical significance of adjuvant chemotherapy for pathological complete response rectal cancer patients with acellular mucin pools after neoadjuvant chemoradiotherapy by Mian Chen, Jianwei Zhang, Yujie Hou, Huashan Liu, Xinjuan Fan, Shuangling Luo, Zhanzhen Liu, Huanxin Hu, Sicong Lai, Liang Kang and Liang Huang in Therapeutic Advances in Gastroenterology</p
Replication Data for: From language to meteorology: kinesis in weather events and weather verbs across Sinitic languages
No full textData generated and/or analysed in the Humanities and Social Sciences Communications article, "From language to meteorology: kinesis in weather events and weather verbs across Sinitic languages
Sicong Ma\u27s Amei Suite & Gaoshan Suite : historical background and performer\u27s guide
Get PDFBefore the Spanish, the Dutch, the Japanese, and the Chinese Mainlanders occupied Taiwan, Austronesians are believed to have been the island’s first immigrants. They are acknowledged as the Aboriginal Taiwanese. Since these people do not have a written language, music, especially singing, became an important means of communication and education for the Aborigines, whose culture is today considered one of the most historically valuable cultures in Taiwan. Sicong Ma (1912-1987) is a major composer who also played an important political role in China. After escaping from China during the Culture Revolution in 1967, Ma was protected by the United States government and settled in the Unites States until he died, He traveled to Taiwan several times as an invited guest of the government, where he gave recitals and conducted symphony orchestras on the island. During his trips to Taiwan, Ma had a chance to attend performances of aboriginal music; this document will explore the influence of this tribal music on his Amei Suite (1973) and Gaoshan Suite (1973), composed after his return to the US. This document will comprise four chapters. The first chapter will explore Sicong Ma’s biographical information and his compositional style, and will also emphasize the connection between Ma and Taiwan. The second chapter will be an introduction to the music of the Taiwanese Aborigines. It will review the musical style of the different tribes, and the use of their instruments, such as double nose flutes, jaw harps, and mouthbows. Chapter three will provide an historical perspective on both of the Ma works under consideration. In cases where it is not possible to consult the original score, the author will concentrate on the musical characters in Ma’s version. The fourth chapter will comprise a performer’s guide. The author will analyze the two suites and give suggestions for interpretation. The goal of this document is to promote the culture of the author’s home country. Moreover, the author hopes that this document will inspire more musicians to analyze and perform works that draw on the folkloric and indigenous idioms of their own countries
Recommended from our members
Machine Learning-based Author Identification for Social Media Forensics
No full textSocial media have gained extreme popularity due to the explosive growth of cyberinfrastructures, mobile devices, Internet technologies, and services. However, they also provide potential anonymity, which in turn harbors hacker forums, carding shops, underground marketplace, dark websites, and so on. As a result, social media have become the playground of cyber threat actors who conduct various malicious operations such as selling stolen cards, disseminating misinformation, propagating hacking tools, spreading malware samples, planning cyberattacks, and organizing trolling campaigns. Therefore, it is urgent to study effective methods that can identify the authors behind the digital text in order to enable forensic analysis, enhance security, and reduce social media misuse. In recent years, machine learning-based author identification has become a promising solution to identify the author of text. However, it is still an underexplored research field in social media forensics. This thesis investigates machine learning-based author identification subfields, including author attribution, author verification, author clustering, and their applications to social media forensics.
Internet Relay Chat (IRC) has traditionally been used for legitimate purposes. Yet, cyber threat actors extensively abuse it to generate a wide range of illegal content and perform malicious behaviors due to its potential anonymity and popularity among hackers. Unfortunately, author identification research in IRC remains a largely underexplored area. In this thesis, we first present our automatic social media monitoring and threat detection method that can effectively collect data for author identification tasks and then present a novel author attribution framework and its application to IRC. It consists of a holistic feature extraction model and an ensemble of ensembles for multi-class classification. We then bring a novel author verification framework under the principle of one-class learning to effectively verify the authorship of IRC texts.
This research also examines author clustering for social media forensics. Most author identification studies focus on author attribution and author verification, while the author clustering research is largely ignored. Meanwhile, cyber threat actors widely make use of Twitter to create alias accounts for numerous malicious purposes, especially in trolling campaigns and misinformation propagations. Thus, developing an effective author clustering method for Twitter is urgent. In this research, we developed a novel unsupervised learning-based author clustering framework and its application to Twitter. We delivered the capability to identify the group among many Twitter aliases even without prior knowledge of the number of authors.
We address the effectiveness and demonstrate the feasibility of our author identification frameworks through diverse experiments. Our author attribution approach can achieve more than 90% attribution accuracy given hundreds of candidates in the author attribution experiments. In the author verification experiments, over 70% of author cases, our author verification approach can achieve more than 99% AUC. In the author clustering experiments given more than one hundred unlabeled text samples, our author clustering approach attains an average accuracy of 81.93% when knowing the number of authors and an average accuracy of 74.78% without prior knowledge of the number of authors
Abstract 4996: The m6A hallmark of cancer: RNA demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation
No full textAbstract
N6-methyladenosine (m6A) is the most prevalent internal modification on mRNA, but its functions in human diseases are poorly understood. The dynamic and reversible m6A modification installed and erased by N6-methyltransferases and demethylases regulates cell fate and gene expression. We show that the m6A demethylase ALKBH5 is highly expressed in patient-derived glioblastoma stem-like cells (GSCs) and informs poor survival of patients with glioblastoma. Silencing ALKBH5 suppresses the proliferation of GSCs in vitro and in vivo. Results of integrated transcriptome and m6A-seq analyses reveal a global change of gene expression enriched in cell cycle and altered expression of select ALKBH5 targets. Among these targets, Ingenuity’s upstream regulator analysis identified FOXM1, an essential transcription factor for GSC proliferation, as a key mediator responsible for the disrupted proliferation program. Using multiple molecular and biochemical approaches, we demonstrate that ALKBH5 binds to and demethylates FOXM1 nascent transcripts. This promotes the interaction of FOXM1 pre-mRNA with HuR, thereby maintaining FOXM1 expression. Further, a long noncoding RNA antisense to the FOXM1 (FOXM1-AS) interacts with ALKBH5 as well as FOXM1 pre-mRNA and promotes their interaction. Depleting ALKBH5 and FOXM1-AS abolishes GSC tumorigenesis through the FOXM1 axis. The vulnerability of GSCs to disruptions in ALKBH5-dependent gene expression suggests that m6A has a central role in tumor development and provides a rationale for therapeutically targeting epitranscriptomic modulators in patients with glioblastoma.
Citation Format: Sicong Zhang, Aidong Zhou, Oliver Bogler, Sadhan Majumder, Suyun Huang. The m6A hallmark of cancer: RNA demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4996. doi:10.1158/1538-7445.AM2017-4996</jats:p
Lexical differentiation in Mandarin Chinese sensory lexicon
No full textHow human beings perceive the world through our five main physiological senses and how such perception is encoded in the human languages are intriguing yet challenging in linguistic studies. Considering uneven studies of Chinese sensory language compared to other Indo-European languages, this study takes the initiative to replicate Strik Lievers and Winter (2018)’s perspective of investigating sensory lexemes distribution across lexical categories, to examine the relationship between Mandarin Chinese sensory lexicon in terms of their parts-of-speech and the five senses. A list of 1,369 sensory related lexemes with annotated lexical categories and sensory modalities were compiled. The quantitative method was used to explore the correlation between sensory modalities and part-of-speech distributions. Chi-squared test yielded a significant result with the p-value<0.05, suggesting a strong relationship between these two categories and the existence of asymmetrical distributions in lexical categories among different senses. In addition, correspondence analysis was conducted, and the result suggests vision is the only sense associated with a high proportion of verbs, taste and touch are more associated to adjectives, while smell and hearing are found preferring nouns. But given there exists a large amount of “deverbal” nouns in auditory sense (occupying 58% of all the nouns), it suggests hearing tends to be more ‘verby’ instead of ‘nouny’. In view of the time-dependency features associated with different lexical categories (see Givón, 1979; 2001[1984]), this study goes further to discuss the ‘time-variant’ in each sense. We adopt Huang (2015; 2016)’s ontological endurant/perdurant dichotomy in which a concept which can be defined independent of time is endurant, and a concept which must be defined dependent of time is perdurant. Since some formal syntacticians suggested lexical categories could be decomposed to +N/+V features, i.e., nouns as [+N, -V], verbs as [-N, +V] and adjectives as [+N, +V] (Haegeman 1994, p.146), Huang (2016) claims that +N feature stands for endurant properties, and +V feature stands for perdurant properties. By decomposing words and linking such features to endurant/perdurant dichotomy, it is possible for us to suggest a ‘sensory endurant/perdurant scale’, on which smell is seen as the most endurant sense, touch and taste are in the middle, while hearing and vision are viewed as the most perdurant modalities
Ma Sicong's Violin Artistry and Compositions
Get PDFMa Sicong was a violinist, composer, and educator of the highest caliber in China who devoted his entire professional life to the instrument. Known for producing violin music in various styles and forms for more than fifty years, Ma Sicong contributed to the violin's popularization in China through his performance and composition with Chinese elements. His violin music incorporates principal melodies from Chinese folk music, and his talents as a mature Western composer talents blend these melodies into violin solos with a distinct national identity.The Inner Mongolia Suite and First Rondo by Ma Sicong, both of which are considered among the most outstanding violin solos ever written for the instrument, are examined in this dissertation, as is the composer's own playing experience, to gain a better understanding of the compositions and their meaning. There are several ramifications for Chinese composition for the violin due to the inclusion of national features that affected the design and development of the violin. The author also hopes that this dissertation can serve as a beneficial resource for future students interested in comparable topics.Music Performanc
Diachrone prototypesemantiek van Chinese radicalen
No full textChinese radicals are the semantic components of Chinese characters that generally indicate the major concept or category to which the Chinese character belongs (see Chen & Chou 2010; Chen 2012; Chou & Huang 2005; Chou & Huang 2006; Huang, Yang & Chen 2008; Yang et al. 2018; Qiu 1988: 11-12). Characters that share the same radical may be semantically linked in various ways to the broad semantic category that the radical represents, and radicals may thus be considered a categorization mechanism to distinguish lexical meanings. In this sense, lexical semantic studies of Chinese radicals are within the scope of prototype-based studies of lexical semantics. However, traditional studies of Chinese characters or radicals in Chinese linguistics are philological in nature (e.g. Lu & Wang 1994; Wang 1996). These studies tend to focus on the origin of radicals and characters, their graphemic development through time, and the symbolic connection between the character's graphemic form and its phonetic aspect. In other words, not only has the cognitive aspect of Chinese radicals been neglected, but also prototype-based studies of Chinese radicals seem to be missing.
Against this backdrop, this dissertation takes the perspective of Cognitive Linguistics to determine which role radicals play as a way of categorization in Chinese characters to fill this research gap. Concretely, the research questions are formulated as follows.
1. How does the semantics of the radical relate to the semantics of the same form when used as an independent character?
2. Do radicals go through internal semantic change? If so, what are the possible diachronic changes that radicals go through? What is the underlying mechanism that drives the semasiological development of radicals?
3. How does radicals' semasiological change influence the word and character networks in which they are involved?
4. As a way of categorization, which role do radicals play in Chinese characters?
Concretely, the project focuses on the FIRE character as a case study in particular given that FIRE is an independent character that can also be used as a radical in composite characters. In view of the first research question, the question arises as to what extent the semantic developments of the FIRE character and the FIRE radical are similar and whether it is possible that the FIRE radical develops independently of the FIRE character. In a first case study (published as Huang et al. 2021), I therefore investigate how the senses of the internal semantic structure of the FIRE character connect as a network. In a second case study (published as Huang et al. 2020), I analyze the semantic structure and development of the FIRE radical as well as the semantic network of composite characters in which the FIRE radical is involved. Finally, I look into variant characters and paronyms incorporating the FIRE radical in order to find out the semantic functions of radicals in so-called radicalization processes, whereby a radical is either added, replaced or removed from a character.
The studies show that to a large extent, the radicals are semantically independent from the independent character they originate from. That is, radicals inherit the most prototypical meaning from their corresponding independent character. From this core meaning, they develop their own clusters of extensions in a radial network. These individual developments can result from the need to capture new concepts following changes in the real world, which are categorized with the radical. They can also follow from the fact that the radical changes indirectly due to the semasiological changes of composite characters featuring the radical. That is, the radical develops semantically because the characters that feature the radical develop semantically over time. However, the radical constrains the semantic development of these characters to some extent, because radicals preferably categorize senses that fit its prototypical circle better than that of other radicals. Hence, the semantic network of the radical results from an interplay between the categorizing function of the radical and the semantic development of characters featuring the radical.
References
Chou, Ya-Min & Chu-Ren Huang. 2005. Hantology: An ontology based on conventionalized conceptualization. In Proceedings of OntoLex 2005 - ontologies and lexical resources. https://aclanthology.org/I05-7002.
Chou, Ya-Min & Chu-Ren Huang. 2006. Hantology-a linguistic resource for Chinese language processing and studying. In Proceedings of the fifth international conference on language resources and evaluation (LREC'06). Genoa, Italy: European Language Resources Association (ELRA).
Huang, Chu-Ren, Ya-Jun Yang & Sheng-Yi Chen. 2008. An ontology of Chinese radicals: Concept derivation and knowledge representation based on the semantic symbols of the four hoofed-mammals. In Proceedings of the 22nd pacific asia conference on language, information and computation, 189-196. The University of the Philippines Visayas Cebu College, Cebu City, Philippines: De La Salle University, Manila, Philippines.
Huang, Chu-Ren. (黄居仁), Sheng-Yi. (陳聖怡) Chen & Ya-Min. (周亞民) Chou. 2010. 語言的知識與知識的語言: 由說文解字出發的知識本體研究 [Knowledge of the Language and the Language of Knowledge: An ontological study based on ShuoWenJieZi]. In Wuyun. (悟雲) Pan & Zhongwei. (鍾偉) Shen (eds.), 《研究之樂：慶祝王士元先生七十五壽辰學術論文集》[The Joy of Research: A Collection of Academic Papers in Celebration of Mr. Wang Shiyuan's 75th Birthday], 106-122. Shanghai: 上海教育出版社 [Shanghai Education Publishing House].
Huang, Danqing, Dirk Geeraerts & Weiwei Zhang. 2020. A semantic analysis of the fire radical in chinese. Revista Diadorim 22(2). 248-276. https://doi.org/10.35520/diadorim.2020.v22n2a39308.
Huang, Danqing, Dirk Geeraerts & Weiwei Zhang. 2021. A diachronic analysis of the FIRE character. Chinese Semiotic Studies. De Gruyter 17(1). 1-44. https://doi.org/10.1515/css-2021-0001.
Yang, Yike, Chu-Ren Huang, Sicong Dong & Si Chen. 2018. Semantic transparency of radicals in Chinese characters: An ontological perspective. In Proceedings of the 32nd pacific asia conference on language, information and computation. Hong Kong: Association for Computational Linguistics.status: Publishe
- …
