39 research outputs found
Supplemental material for Two-way partial AUC and its properties
No full textSupplemental Material for Two-way partial AUC and its properties by Hanfang Yang, Kun Lu, Xiang Lyu and Feifang Hu in Statistical Methods in Medical Research</p
Strategic plan of ZY Company
No full textZY Company was founded in Shanghai in 2006, which has been dedicated to adult higher
education and vocational skills training, and has been among the top three in the industry.
However, in the past two years, with a series of reform programs and measures issued by the
Ministry of Education, the main business of ZY Company has been greatly impacted. Based
on this, how to comprehensively analyze the company's own situation and grasp the current
internal and external environments, and implement the business transformation is the real
problem that ZY Company needs to solve, which is also the core problem studied in this study.
To achieve this goal, this study uses literature review method, PESTL analysis and
Porter's Five Forces model to sort out and analyze the status of ZY company, external macro
environment and industry environment. At the same time, the in-depth interview method is
used to further understand ZY company, analyze the company's customer types according to
different dimensions, thus establishing a typical customer profile, and enhancing the
company's market competitiveness through precise marketing. In addition, SWOT analysis is
applied to comprehensively analyze ZY's strengths, weaknesses, opportunities and challenges.
Finally, VRIO model and BCG Matrix are used to qualitatively and quantitatively analyze the
internal and external factors of ZY Company, and a questionnaire is designed to understand
the implementation of all aspects of transformation within the company. After all these
analyses, the development strategy and business type that meets the actual situation of ZY
Company is finally determined.A empresa ZY foi fundada em Xangai em 2006 e dedica-se ao ensino superior para adultos e
à formação de competências profissionais, encontrando-se entre as três primeiras do sector.
No entanto, nos últimos dois anos, com uma série de programas e medidas de reforma
emitidos pelo Ministério da Educação, a atividade principal da ZY Company sofreu um
grande impacto. Com base nisto, como analisar exaustivamente a situação da própria empresa
e compreender os actuais ambientes interno e externo, e implementar a transformação
empresarial éo verdadeiro problema que a empresa ZY precisa de resolver, que étambém o
problema central estudado neste estudo.
Para atingir este objetivo, este estudo utiliza o método de pesquisa bibliográfica, a
análise PESTL e o modelo das Cinco Forças de Porter para classificar e analisar a situação da
empresa ZY, o ambiente macro externo e o ambiente da indústria. Ao mesmo tempo, o
método de entrevista aprofundada é utilizado para compreender melhor a empresa ZY,
analisar os tipos de clientes da empresa de acordo com diferentes dimensões, estabelecendo
assim um perfil de cliente típico, e melhorar a competitividade da empresa no mercado
através de um marketing preciso. Além disso, a análise SWOT é aplicada para analisar
exaustivamente os pontos fortes, os pontos fracos, as oportunidades e os desafios da empresa
ZY. Por último, o modelo VRIO e a matriz BCG são utilizados para analisar qualitativa e
quantitativamente os factores internos e externos da empresa ZY, e é elaborado um
questionário para compreender a implementação de todos os aspectos da transformação na
empresa. Após todas estas análises, éfinalmente determinada a estratégia de desenvolvimento
e o tipo de negócio que corresponde àsituação atual da empresa ZY
Strategic plan of ZY Company
No full textZY Company was founded in Shanghai in 2006, which has been dedicated to adult higher
education and vocational skills training, and has been among the top three in the industry.
However, in the past two years, with a series of reform programs and measures issued by the
Ministry of Education, the main business of ZY Company has been greatly impacted. Based
on this, how to comprehensively analyze the company's own situation and grasp the current
internal and external environments, and implement the business transformation is the real
problem that ZY Company needs to solve, which is also the core problem studied in this study.
To achieve this goal, this study uses literature review method, PESTL analysis and
Porter's Five Forces model to sort out and analyze the status of ZY company, external macro
environment and industry environment. At the same time, the in-depth interview method is
used to further understand ZY company, analyze the company's customer types according to
different dimensions, thus establishing a typical customer profile, and enhancing the
company's market competitiveness through precise marketing. In addition, SWOT analysis is
applied to comprehensively analyze ZY's strengths, weaknesses, opportunities and challenges.
Finally, VRIO model and BCG Matrix are used to qualitatively and quantitatively analyze the
internal and external factors of ZY Company, and a questionnaire is designed to understand
the implementation of all aspects of transformation within the company. After all these
analyses, the development strategy and business type that meets the actual situation of ZY
Company is finally determined.A empresa ZY foi fundada em Xangai em 2006 e dedica-se ao ensino superior para adultos e
à formação de competências profissionais, encontrando-se entre as três primeiras do sector.
No entanto, nos últimos dois anos, com uma série de programas e medidas de reforma
emitidos pelo Ministério da Educação, a atividade principal da ZY Company sofreu um
grande impacto. Com base nisto, como analisar exaustivamente a situação da própria empresa
e compreender os actuais ambientes interno e externo, e implementar a transformação
empresarial éo verdadeiro problema que a empresa ZY precisa de resolver, que étambém o
problema central estudado neste estudo.
Para atingir este objetivo, este estudo utiliza o método de pesquisa bibliográfica, a
análise PESTL e o modelo das Cinco Forças de Porter para classificar e analisar a situação da
empresa ZY, o ambiente macro externo e o ambiente da indústria. Ao mesmo tempo, o
método de entrevista aprofundada é utilizado para compreender melhor a empresa ZY,
analisar os tipos de clientes da empresa de acordo com diferentes dimensões, estabelecendo
assim um perfil de cliente típico, e melhorar a competitividade da empresa no mercado
através de um marketing preciso. Além disso, a análise SWOT é aplicada para analisar
exaustivamente os pontos fortes, os pontos fracos, as oportunidades e os desafios da empresa
ZY. Por último, o modelo VRIO e a matriz BCG são utilizados para analisar qualitativa e
quantitativamente os factores internos e externos da empresa ZY, e é elaborado um
questionário para compreender a implementação de todos os aspectos da transformação na
empresa. Após todas estas análises, éfinalmente determinada a estratégia de desenvolvimento
e o tipo de negócio que corresponde àsituação atual da empresa ZY
Strategic development plan of adult training company
No full textUnder the background of globalization and knowledge economy, the internationalization of education is not only a trend, but also an important force to promote global integration.ZY Company, as a pioneer in the education and training industry based in Shanghai and covering three provinces, has already made remarkable achievements in the industry thanks to years of deep cultivation in the industry. However, with the constant changes in national policies and the increasingly fierce competition in the market, ZY Company urgently needs to transform and formulate a new development strategy in order to realize the long-term and stable development of the company.
This study uses literature review method, PESTE analysis and Porter's Five Forces model to sort out and analyze the status of ZY company, external macro environment and industry environment. At the same time, the in-depth interview method is used to further understand ZY company, analyze the company's customer types according to different dimensions, thus establishing a typical customer profile. In addition, SWOT analysis is applied to comprehensively analyze ZY's strengths, weaknesses, opportunities and challenges. Finally, VRIO model and BCG Matrix are used to qualitatively and quantitatively analyze the internal and external factors of ZY Company, and a questionnaire is designed to understand the implementation of all aspects of transformation within the company.
Based on these analyses, this study concludes that ZY Company needs to continuously explore the market development, find the target market according to the type of customers, and adopt appropriate methods to further expand its market share.No contexto da globalização e da economia do conhecimento, a internacionalização da educação não é apenas uma tendência, mas também uma força importante para promover a integração global. A ZY Company, pioneira no sector da educação e da formação, com sede em Xangai e abrangendo três províncias, já alcançou resultados notáveis no sector, graças a anos de crescimento profundo no sector. No entanto, com as políticas nacionais em constante mudança e a concorrência cada vez mais feroz no mercado, a ZY Company precisa urgentemente de se transformar e formular uma nova estratégia de desenvolvimento, a fim de alcançar um desenvolvimento estável a longo prazo da empresa.
Este estudo utiliza o método de revisão da literatura, a análise PESTE e o modelo das Cinco Forças de Porter para classificar e analisar a situação da empresa ZY, o ambiente macro externo e o ambiente do sector. Ao mesmo tempo, o método de entrevista aprofundada é utilizado para compreender melhor a empresa ZY, analisar os tipos de clientes da empresa de acordo com diferentes dimensões, estabelecendo assim um perfil de cliente típico. Além disso, é aplicada a análise SWOT para analisar exaustivamente os pontos fortes, os pontos fracos, as oportunidades e os desafios da ZY. Por último, o modelo VRIO e a matriz BCG são utilizados para analisar qualitativa e quantitativamente os factores internos e externos da empresa ZY, e é elaborado um questionário para compreender a implementação de todos os aspectos da transformação na empresa.
Com base nestas análises, o presente documento defende que a empresa ZY precisa de explorar continuamente o desenvolvimento do mercado, encontrar o mercado-alvo de acordo com o tipo de clientes e adotar métodos adequados para expandir ainda mais a sua quota de mercado
Effect of Methionine Hydroxy Analog on Hu Sheep Digestibility, Rumen Fermentation, and Rumen Microbial Community In Vitro
No full textThis experiment was conducted to evaluate the effects of a methionine hydroxy analog (MHA) on in vitro gas production, rumen fermentation parameters, and rumen microbiota. Two different MHA, 2-hydroxy-4-(methylthio) butanoic acid isopropyl ester (HMBi) and the calcium salt of the hydroxy analog of methionine (MHA-Ca), were selected for in vitro experiments. The treatments were the Control group (0% of MHA), HMBi group (2%HMBi), and MHA-Ca group (2%MHA-Ca). Dry matter digestibility was measured after 12 h and 24 h of fermentation, and fermentation parameters and microbial composition were analyzed after 24 h. HMBi and MHA-Ca showed increased (p = 0.001) cumulative gas production in 3 h. The total volatile fatty acids, microbial protein (MCP) concentration, acetate, and acetate to propionate ratio in the HMBi and MHA-Ca groups were significantly higher than those in the Control group (p = 0.006, p = 0.002, p = 0.001, p = 0.004), and the NH3-N concentrations in the HMBi and MHA-Ca groups were significantly lower than those in the Control group (p = 0.004). The 16S rRNA sequencing revealed that the HMBi group had a higher (p = 0.039, p = 0.001, p = 0.027) relative abundance of Bacteroidetes, Firmicutes, and Synergistetes and a lower relative abundance of Proteobacteria (p = 0.001) than the Control group. At the genus level, Prevotella abundance was higher (p = 0.001), while Ruminobacter abundance was lower (p = 0.001), in the HMBi and MHA-Ca groups than in the Control group. Spearman’s correlation analysis showed that the relative abundance of Prevotella_1, Streptococcus, and Desulfovibrio was positively correlated with dry matter digestibility, MCP, and fermentation parameters. MHA, thus, significantly increased gas production and altered the rumen fermentation parameters and microbiota composition of sheep
Two-way partial AUC and its properties
No full text Simultaneous control on true positive rate and false positive rate is of significant importance in the performance evaluation of diagnostic tests. Most of the established literature utilizes partial area under receiver operating characteristic (ROC) curve with restrictions only on false positive rate (FPR), called FPR pAUC, as a performance measure. However, its indirect control on true positive rate (TPR) is conceptually and practically misleading. In this paper, a novel and intuitive performance measure, named as two-way pAUC, is proposed, which directly quantifies partial area under ROC curve with explicit restrictions on both TPR and FPR. To estimate two-way pAUC, we devise a nonparametric estimator. Based on the estimator, a bootstrap-assisted testing method for two-way pAUC comparison is established. Moreover, to evaluate possible covariate effects on two-way pAUC, a regression analysis framework is constructed. Asymptotic normalities of the methods are provided. Advantages of the proposed methods are illustrated by simulation and Wisconsin Breast Cancer Data. We encode the methods as a publicly available R package tpAUC. </jats:p
Modeling Population Dynamics and Assessing Ecological Impacts of Lampreys via Sex Ratio Regulation
No full textRegulating lamprey populations is crucial for maintaining ecological equilibrium. However, the unique sex determination process of lampreys is constrained by multiple factors, complicating intuitive analysis of population dynamics and their impact on the natural environment. This study employed a two-species competition mechanism to elucidate the factors influencing sex ratios and their mechanistic effects on lamprey population size. Using the Lotka–Volterra equations, we investigated how sex ratios affect trophic levels both upstream and downstream of lampreys in the food web. A logistic population growth model was applied to assess the impact of sex ratio variations on symbiotic parasitic species, while the Analytic Hierarchy Process (AHP) was utilized to explore the dynamic relationship between sex ratio changes and ecosystem stability. To validate model efficacy, we manipulated temperature and food availability under controlled disturbance conditions, analyzing temporal variations in lamprey population size across different disturbance intensities to evaluate model sensitivity. The findings indicate that the variable sex ratio’s benefit is in facilitating the lampreys’ population’s enhanced adaptation to environmental shifts. The coexisting species exhibit a similar pattern of population alteration as the lampreys, albeit with a minor delay. A definitive link between the quantity of lampreys and the parasitic species is absent. A male ratio of 0.6 optimally contributes to the ecosystem’s equilibrium. Over time, the configuration of our model’s parameters proves to be sensible. This research provides robust theoretical support for developing scientific strategies to regulate lamprey populations
Human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer: how the latest results are improving therapeutic options
No full textHuman epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer (MBC) remains an incurable disease, and approximately 25% of patients with HER2+ early breast cancer still relapse after adjuvant trastuzumab-based treatment. HER2 is a validated therapeutic target that remains relevant throughout the disease process. Recently, a number of novel HER2 targeted agents have become available, including lapatinib (a small molecule tyrosine kinase inhibitor of both HER2 and the epidermal growth factor receptor), pertuzumab (a new anti-HER2 monoclonal antibody) and ado-trastuzumab emtansine (T-DM1, a novel antibody-drug conjugate), which provide additional treatment options for patients with HER2+ MBC. The latest clinical trials have demonstrated improved outcome with treatment including pertuzumab or T-DM1 compared with standard HER2 targeted therapy. Here we review the clinical development of approved and investigational targeted agents for the treatment of HER2+ MBC, summarize the latest results of important clinical trials supporting use of these agents in the treatment of HER2+ MBC, and discuss how these results impact therapeutic options in clinical practice.SCI(E)[email protected]
Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf.
No full textLow-cost biosorbents (ginkgo leaf, osmanthus leaf, banyan leaf, magnolia leaf, holly leaf, walnut shell, and grapefruit peel) were evaluated in the simultaneous removal of La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Yb3+, Lu3+, UO22+, Th4+, Y3+, Co2+, Zn2+, Ni2+, and Sr2+ from aqueous solutions. In single metal systems, all adsorbents exhibited good to excellent adsorption capacities toward lanthanides and actinides. In a simulated multicomponent mixed solution study, higher selectivity and efficiency were observed for Th4+ over other metal cations, with ginkgo leaves providing the highest adsorptivity (81.2%) among the seven biosorbents. Through optimization studies, the selectivity of Th4+ biosorption on ginkgo leaf was found to be highly pH-dependent, with optimum Th4+ removal observed at pH 4. Th4+ adsorption was found to proceed rapidly with an equilibrium time of 120 min and conform to pseudo-second-order kinetics. The Langmuir isotherm model best described Th4+ biosorption, with a maximum monolayer adsorption capacity of 103.8 mg g-1. Thermodynamic calculations indicated that Th4+ biosorption was spontaneous and endothermic. Furthermore, the physical and chemical properties of the adsorbent were determined by scanning electron microscopy, Brunauer-Emmett-Teller, X-ray powder diffraction, and Fourier transform infrared analysis. The biosorption of Th from a real sample (monazite mineral) was studied and an efficiency of 90.4% was achieved from nitric acid at pH 4 using ginkgo leaves
