14,369 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
台灣高雄縣大岡山石灰岩 (更新世) 產腕足動物化石. (Five Species of Brachiopod Fossils from Takangshan Limestone, (Pleistocene), Kaohsung Prefecture, Taiwan).
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台灣南投縣中寮鄉福盛村大坑層 (中部中新世) 產軟體動物化石 (二) (雙殼類之研究) (Studies on the Molluscan fauna from the Taken Formation (middle Miocene), Chunglio County, Nantou Prefecture, Taiwan (II).
No full textStudies on the Molluscan fauna from the Taken Formation, Chunglio County, Nantou Prefecture Taiwan (1) (Gastropoda and Problematics).
No full textStudies on Quaternary fossil crabs and associated faunas from Hainan Island, southern China.
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