2,104 research outputs found
Assessing chronic disease progression using non-homogenous exponential regression Markov models
No full textConstructing node-disjoint paths in enhanced pyramid networks
No full text[[abstract]]Chen et al. in 2004 proposed a new hierarchy structure, called the enhanced pyramid network (EPM, for short), by replacing each mesh in a pyramid network (PM, for short) with a torus. Recently, some topological properties and communication on the EPMs have been investigated or derived. Their results have revealed that an EPM is an attractive alternative to a PM. This study investigates the node-disjoint paths between any two distinct nodes and the upper bound of the omega-wide-diameter of an EPM. This result shows that the EPMs have smaller omega-wide-diameters than the PMs.[[note]]SC
omega-wide diameters of enhanced pyramid networks
No full text[[abstract]]Chen et al. proposed in 2004 a new hierarchy structure, called the enhanced pyramid network (EPM), by replacing each mesh in a pyramid network (PM) with a torus. Recently, some topological properties and communication on an EPM have been investigated or derived. Their measurement results indicate that an EPM is an attractive alternative to a PM. This study investigates the node-disjoint paths between any two distinct nodes and computes upper and lower bounds of omega-wide diameters of an EPM. After minimizing upper bounds and maximizing lower bounds, omega-wide diameters of an EPM can then be determined. (C) 2011 Elsevier B.V. All rights reserved.[[note]]SC
Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish.
No full textCrossed pulmonary arteries: report of two cases with emphasis on three-dimensional helical computed tomographic imaging.
No full textDevelopment of active safety surveillance system for traditional Chinese medicine: An empirical study in treating climacteric women
No full textConditional expression of a myocardium-specific transgene in zebrafish transgenic lines.
No full textAssessment of cardiac morphology and function in heart-specific green fluorescent zebrafish.(accepted)
No full textRegulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells
Full text linkAbstract Background Vascular endothelial cells (ECs) constantly experience fluid shear stresses generated by blood flow. Laminar flow is known to produce atheroprotective effects on ECs. Nrf2 is a transcription factor that is essential for the antioxidant response element (ARE)-mediated induction of genes such as heme-oxygenase 1 (HO-1). We previously showed that fluid shear stress increases intracellular reactive oxygen species (ROS) in ECs. Moreover, oxidants are known to stimulate Nrf2. We thus examined the regulation of Nrf2 in cultured human ECs by shear stress. Results Exposure of human umbilical vein endothelial cells (HUVECs) to laminar shear stress (12 dyne/cm2) induced Nrf2 nuclear translocation, which was inhibited by a phosphatidylinositol 3-kinase (PI3K) inhibitor, a protein kinase C (PKC) inhibitor, and an antioxidant agent N-acetyl cysteine (NAC), but not by other protein kinase inhibitors. Therefore, PI3K, PKC, and ROS are involved in the signaling pathway that leads to the shear-induced nuclear translocation of Nrf2. We also found that shear stress increased the ARE-binding activity of Nrf2 and the downstream expression of HO-1. Conclusion Our data suggest that the atheroprotective effect of laminar flow is partially attributed to Nrf2 activation which results in ARE-mediated gene transcriptions, such as HO-1 expression, that are beneficial to the cardiovascular system.</p
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