903 research outputs found

    sj-docx-1-tam-10.1177_17588359231221907 – Supplemental material for Major adverse cardiovascular events in advanced-stage lung cancer: a multicenter cohort study

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    Supplemental material, sj-docx-1-tam-10.1177_17588359231221907 for Major adverse cardiovascular events in advanced-stage lung cancer: a multicenter cohort study by Chih-Hao Chang, Shih-Hao Huang, Hung-Yu Huang, Meng-Hung Lin, Chung-Shu Lee, Hsin-Fu Lee, Jason Chia-Hsun Hsieh and Chun-Yu Cheng in Therapeutic Advances in Medical Oncology</p

    Copepod Abundance and Species Composition of Tanshui River Estuary and Adjacent Waters

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    Tanshui River is the most important river of northern Taiwan, but has been polluted by industrial discharge & domestic sewage. In order to build up the baseline information of natural resource for management & protection of the estuarine ecosystem, we studied copepods, the dominant taxonomical group of the zooplankton, from the estuary & adjacent offshore waters in August, October, November 1996 & January 1997. In total, 62 species belonging to 27 genera & 17 families in Calanoida, Cyclopoida, Harpacticoida & Poecilostomatoida were identified. We found that the abundance of copepods in the estuary was lower than that in the offshore waters. This phenomenon may due to the out-flowing of polluted water from the Tanshui River. The species composition was found to be affected by environmental condition. The change of dominant species among the four sampling months exhibits a temporal variation of the copepod assemblages in this area. General pattern of production & peculiarity of local copepod fauna among various studies are discussed

    FAR-RED INSENSITIVE219 Modulates CONSTITUTIVE PHOTOMORPHOGENIC1 Activity via Physical Interaction to Regulate Hypocotyl Elongation in Arabidopsis

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    AbstractFAR-RED INSENSITIVE219 (FIN219) in Arabidopsis (Arabidopsis thaliana) is involved in phytochrome A-mediated far-red (FR) light signaling. Previous genetic studies revealed that FIN219 acts as an extragenic suppressor of CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1). However, the molecular mechanism underlying the suppression of COP1 remains unknown. Here, we used a transgenic approach to study the regulation of COP1 by FIN219. Transgenic seedlings containing ectopic expression of the FIN219 amino (N)-terminal domain in wild-type Columbia (named NCox for the expression of the N-terminal coiled-coil domain and NTox for the N-terminal 300-amino acid region) exhibited a dominant-negative long-hypocotyl phenotype under FR light, reflected as reduced photomorphogenic responses and altered levels of COP1 and ELONGATED HYPOCOTYL5 (HY5). Yeast two-hybrid, pull-down, and bimolecular fluorescence complementation assays revealed that FIN219 could interact with the WD-40 domain of COP1 and with its N-terminal coiled-coil domain through its carboxyl-terminal domain. Further in vivo coimmunoprecipitation study confirms that FIN219 interacts with COP1 under continuous FR light. Studies of the double mutant fin219-2/cop1-6 indicated that HY5 stability requires FIN219 under darkness and FR light. Moreover, FIN219 levels positively regulated by phytochrome A can modulate the subcellular location of COP1 and are differentially regulated by various fluence rates of FR light. We conclude that the dominant-negative long-hypocotyl phenotype conferred by NCox and NTox in a wild-type background was caused by the misregulation of COP1 binding with the carboxyl terminus of FIN219. Our data provide a critical mechanism controlling the key repressor COP1 in response to FR light.</jats:p

    Nearly White Light Illumination from a GaN-Based Light Emitting Diode Integrated with a Porous SiO2 Layer

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    本研究中,我們使用多孔之二氧化矽薄膜當作紅光光源以及氮化鎵材料之藍/綠光發光二極體,整合成一個能發出近白光的元件。我們分別使用電漿輔助化學氣相沉積系統濕蝕刻以及電感耦合電漿離子蝕刻機以及熱退火形成一多孔之二氧化矽薄膜以及奈米晶矽,並且將其成長於發光二極體之N型平台上,紅光即可從這金屬-氧化物-半導體結構中藉由電子電洞於奈米晶矽複合而產生。在電壓加至14伏特以及16伏特之間時,我們可以發現近白光由此元件而產生,由此實驗的結果可以看出,由此種元件的組合而形成白光是相當具有潛力的。In this research, we develop a nearly white light emitting device by integrating blue/green emission from a GaN based light emitting diode (LED) with red emission from a porous SiO2 layer. The porous SiO2 layer was fabricated by a novel process procedure to create Si nanocrystals on top of the n-type GaN layer. Red light is generated from the metal-oxide-semiconductor (Ni/Au–SiO2 oxide-n-type GaN) structure due to the electron-hole recombination in the Si nanocrystals. The device shows a blue light emission at a low biased voltage and nearly white light emission (green and red colors) at a bias voltage between 14V and 16V. Our results show the potential of applying such an integrated structure to white light illumination.目錄 第一章 簡介 1-1 論文架構.............................................1 1-2白光發光二極體背景簡介................................2 1-3氮化鎵之P型區域電流擴散簡介...........................3 1-4 矽氧化物發可見光之研究背景簡介.......................4 1-5 研究動機.............................................5 參考文獻.................................................6 第二章 晶片製作 2-1 簡介.................................................8 2-2 晶片結構............................................10 2-3 製作流程............................................12 參考文獻................................................16 第三章 不同P型電極之LED比較 3-1 簡介................................................17 3-2 圖形設計及發光效率探討..............................18 3-3 小結................................................28 參考文獻................................................31 第四章 藍綠光LED與SiO2合成發光實驗 4-1 簡介................................................32 4-2 結構及製作流程......................................33 4-3 測量結果及討論......................................36 4-4 小结................................................41 參考文獻................................................42 第五章 總結 5-1 論文回顧............................................4
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