49,047 research outputs found
Pseudohallucinations versus true hallucinations in prodromal psychosis: Does it really matter?
No full textA tandem Heck reaction leading to a 26-membered carbocycle
No full textSequential inter- and intramolecular Heck reactions have been used to construct a 26-membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation
The first total synthesis of (+/-)-1-desoxyhypnophilin
No full textThe paper describes the first total synthesis of (+/-)-1-desoxyhypnophilin, a linear triquinane from the East African mushroom Lentinus crinitus which displays promising antimicrobial activity. A key feature is the use of a ring closing metathesis reaction with a tertiary allylic alcohol, in conjunction with a PCC induced oxidative rearrangement, to construct a cyclopentenone
The synthesis of a natural product family: from debromoisolaurinterol to the aplysins
No full textTotal syntheses of (+/-)-aplysin 1, (+/-)-debromoaplysin 2, (+/-)-isoaplysin 3, (+/-)-aplysinol 4, (+/-)-debromoaplysinol 5, (+/-)-aplysinal 6, (+/-)-isolaurinterol 7 and (+/-)-debromoisolaurinterol 8 are described. Key features are a diastereoselective, sulfur mediated radical cyclisation of diene 12 to give 35; a new radical to polar crossover sequence mediated by Bu3Sn that transforms diene 12 into (+/-)-debromoisolaurinterol 8; and a series of biomimetic cyclisation and oxidation reactions
A total synthesis of (+/-)-1-desoxyhypnophilin: using ring closing metathesis for the construction of cyclic enones
No full textThe paper describes the first total synthesis of (+/-)-1-desoxyhypnophilin, a linear triquinane isolated from the East African mushroom Lentinus crinitus which displays promising antimicrobial activity. The key strategic feature is a new cyclopentannulation method for appending cycloalkenones onto ketones involving sequential use of a ring closing metathesis reaction with a tertiary allylic alcohol and a PCC induced oxidative rearrangement
MONO(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES AND BIS(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES - SYNTHESIS, STRUCTURE, AND PROPERTIES
No full textJutzi P, KANNE D, HURSTHOUSE M, HOWES AJ. MONO(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES AND BIS(ETA-1-PENTAMETHYLCYCLOPENTADIENYL)SILANES - SYNTHESIS, STRUCTURE, AND PROPERTIES. CHEMISCHE BERICHTE-RECUEIL. 1988;121(7):1299-1305
Long-term growth in vitro of isolated, fully differentiated neurones from the central nervous system of an adult insect
No full textA method is described for the isolation and growth in vitro of fully differentiated neurones from the thoracic ganglia of adult cockroaches. The presence of insect blood in the culture system is shown to promote growth. The morphology of the growing neurones and the plasticity of the branching processes are described and growth rates are measured. Using a fluorescent Ca2+ indicator dye, changes of intracellular calcium levels in the growing neurones in response to K+ depolarization have been measured. The results, indicating the presence of voltage-dependent Ca2+ channels on neuronal processes in vitro, show that neurones can be maintained in a functional state for several weeks by this technique. Such preparations could prove useful for studying a variety of physiological and pharmacological properties of neurones, including the mechanisms controlling growth, synapse formation and neuronal interactions with other cell types. <br/
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