3,839 research outputs found

    Benjamin Rogers Howell

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    Benjamin Rogers Howell handed to President Kingsbury his resignation from the Faculty of the University of Utah, to take effect at the close of the next summer school session. Mr. Howell gave up this position to enter the practice of la

    Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma

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    Vascular endothelial growth factor (VEGF) is a potent regulator of vasculogenesis and tumour angiogenesis. We have investigated whether the VEGF -2578, -1154, +405 and +936 SNPs and associated haplotypes confer susceptibility to and/or influence prognosis in cutaneous malignant melanoma (CMM) skin cancer. A total of 152 CMM patients and 266 controls were genotyped for VEGF promoter SNPs by ARMS-PCR. Strong linkage disequilibrium between the -2578, -1154 and +405 SNPs was detected (association, rho = 0.488-0.965), but not between these SNPs and SNP +936 (association, rho = 0.004-0.130). No SNPs or three SNP haplotypes (-2578, -1154, +405) were significantly associated with CMM, although a number of non-significant trends were observed. However, the VEGF -1154 AA genotype and -2578, -1154, +405 CAC haplotype were both significantly associated with less advanced (Stage 1) disease (P = 0.03). In addition, the VEGF -1154 AA genotype was associated with thinner primary vertical growth phase tumours (P = 0.002), while VEGF -1154 GG was associated with thicker primary tumours (P = 0.02). These preliminary results indicate that VEGF genotype may influence tumour growth in CMM, possibly via the effects of differential VEGF expression on tumour angiogenesis

    Walter E. Oberer Retirement Luncheon

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    Dean Oberer was emeritus of law and former dean of the S.J. Quinney College of Law. He received the Burlington Resources Foundation Faculty Achievement Award in 1991 and was particularly noted for his scholarship in labor law and was co-author of a book, "Cases and Materials on Labor Law: Collective Bargaining in a Free Society.

    Data for "A model for extreme plasticity" by S.J. Thomson and P.D. Howell

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    See README file in Dataset This data was generated as a result of the study of the extreme plastic deformation of metal samples. This data was included in the paper "A model for extreme plasticity" published in Journal of the Mechanics and Physics of Solids

    Arsaces Armeniae rex in scenam dabitvr ab auctoribus & actoribus eloquentiæ studiosis in collegio societatis Iesv Antverpiæ die [ ] ianuarij, M.DC.XXXIX.

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    Probably printed in AntwerpBacker-Sommervogel [S.J.] VIII, 1667, nr. 30bis; VIII, 9, nr. 1 (mentions Gilles Thybault as the author)Europeana-GoogleBook

    Influence of TNFalpha and LTalpha single nucleotide polymorphisms on susceptibility to and prognosis in cutaneous malignant melanoma in the British population

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    Cutaneous malignant melanoma (CMM) is a potentially fatal malignancy in which exposure to UV light is the most important risk factor. Several lines of evidence suggest that increased expression of tumour necrosis factor (TNF) ?, upregulated by UV exposure, may contribute to tumour escape from the immune response. In this study, we addressed whether single nucleotide polymorphisms (SNPs) in the TNF? promoter and lymphotoxin (LT) ? gene are associated with susceptibility to or known prognostic indicators (e.g. initial tumour growth phase, Breslow thickness, mitotic count in vertical growth phase tumours, and tumour regression) in CMM. One hundred and forty-six British Caucasian CMM patients and 220 controls were typed for TNF??376, ?308 and ?238 and LT? +252 SNPs by ARMS-PCR. Only the TNF??238 GG (P = 0.05) and GA (P = 0.03) genotypes showed slight, but significant, associations with CMM, while LT? +252 AA was associated with a higher mitotic count in vertical growth phase tumours (P = 0.02). Both TNF??238 and LT? +252 SNPs showed linkage disequilibrium with HLA-DQB1*0303 and *0301 alleles, variably implicated in CMM susceptibility/prognosis. In addition, TNF??238, ?308, LT? +252 haplotypes were assigned and compared. The GGA haplotype showed a modest association with CMM (P = 0.04) and with stage of disease (P = 0.03) and initial growth phase in CMM (P = 0.02), but these associations were only significant when P-values were uncorrected. Unlike basal cell carcinoma, these preliminary findings suggest that genetic variation associated with differential TNF? and LT? production is unlikely to play a major, independent role in susceptibility to, and perhaps prognosis in, CMM

    Daily Reflections (Meditations) on the Scriptures from the Roman Catholic Lectionary.

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    The recipients of the Letter to the Hebrews were folks who were flagging in their commitment to faith and the Christian life.  The author addresses their lack of faith in the sacrifice and priesthood of Jesus.  Hebrews has been the focus of the first readings in Ordinary Time since the ending of the Christmas season.|We all need to hear that message of the author because of our need to grow in faithfulness and love as we encounter the daily-ness of our lives.  Let's look at just one of the features expressed in the first reading for today's liturgy.|The reading is from the last chapter of Hebrews, a kind of summary of how to live effectively with the will to follow Jesus and make that following effective in their everyday lives.   The people are exhorted to live simply and to trust that "the Lord is my helper and I will not be afraid.  What can anyone do to me?"|The virtues they are called to live out seem to be fundamental for living the Christ-life within them (and, clearly, within us): "do not neglect hospitality;" "be mindful of prisoners;" "let marriage be honored;" "let your life be free from love of money."   How do these injunctions relate to us today?|This list seems doable; there's not a grand scheme here that we'd think of as way beyond what we might be called to accomplish.  There's a simplicity here that is inviting for our growth as persons of faith and a members of the Body of Christ.  We're not asked to convert vast numbers of our contemporaries, but only to be attentive to those around us.|Take "hospitality" for example.  Can I be open to offering hospitality to those I meet?  This sounds simple enough, but there's a lot more to it in the fast-paced world around us.  It is so easy for me to refuse the person in need who approaches me and asks for a hand-out.   Do I see Christ in that person?   I have to conclude that I do not.  With that said, I need to look to continued conversion in faith. |Multiply my little encounter and consider a more pressing issue of hospitality: the thousands who are fleeing from their homelands as refugees.  Where is Christ in our response to these people?  Can we even see Christ's or God's call to respond in faith, hope and love?  What WOULD Jesus do?|Merciful God, help us to reflect your goodness, mercy and forgiveness in our present situations.  Keep us faithful to your Word (in the Good News and in the very person of Jesus).  Open us to your guidance and be with us as the very source of all life.  Thank you for the opportunities to discover you in our daily lives and histories.  Help us to know that YOU are the source of our freedom and that you call us to fearlessness in our living and serving with you.  Thank you for approaching us and our often faltering commitment in faith. This reflection was was written by Tom Shanahan, S.J., for this date, in 2017

    Radar observations of Asteroids 64 Angelina and 69 Hesperia

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    We report new radar observations of E-class Asteroid 64 Angelina and M-class Asteroid 69 Hesperia obtained with the Arecibo Observatory S-band radar (2480MHz, 12.6cm). Our measurements of Angelina\u27s radar bandwidth are consistent with reported diameters and poles. We find Angelina\u27s circular polarization ratio to be 0.8±0.1, tied with 434 Hungaria for the highest value observed for main-belt asteroids and consistent with the high values observed for all E-class asteroids (Benner, L.A.M., Ostro, S.J., Magri, C., Nolan, M.C., Howell, E.S., Giorgini, J.D., Jurgens, R.F., Margot, J.L., Taylor, P.A., Busch, M.W., Shepard, M.K. [2008]. Icarus 198, 294-304; Shepard, M.K., Kressler, K.M., Clark, B.E., Ockert-Bell, M.E., Nolan, M.C., Howell, E.S., Magri, C., Giorgini, J.D., Benner, L.A.M., Ostro, S.J. [2008b]. Icarus 195, 220-225). Our radar observations of 69 Hesperia, combined with lightcurve-based shape models, lead to a diameter estimate, D =110±15km, approximately 20% smaller than the reported IRAS value. We estimate Hesperia to have a radar albedo of σ̂OC=0.45±0.12, consistent with a high-metal content. We therefore add 69 Hesperia to the Mm-class (high metal M) (Shepard, M.K., Clark, B.E., Ockert-Bell, M., Nolan, M.C., Howell, E.S., Magri, C., Giorgini, J.D., Benner, L.A.M., Ostro, S.J., Harris, A.W., Warner, B.D., Stephens, R.D., Mueller, M. [2010]. Icarus 208, 221-237), bringing the total number of Mm-class objects to eight; this is 40% of all M-class asteroids observed by radar to date. © 2011 Elsevier Inc. ef

    Property A and affine buildings

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    Yu's Property A is a non-equivariant generalisation of amenability introduced in his study of the coarse Baum Connes conjecture. In this paper we show that all affine buildings of type A2, B2 and G2 have Property A. Together with results of Guentner, Higson and Weinberger, this completes a programme to show that all affine building have Property A. In passing we use our technique to obtain a new proof for groups acting on buildings.The author was supported by EPSRC postdoctoral fellowship EP/C53171X/1.<br/
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