2,560 research outputs found
'Pilings of Thought Under Spoken': The Poetry of Susan Howe, 1974-1993.
No full textPhDThis thesis discusses the poetry published by contemporary American poet Susan
Howe over a period of almost two decades. The dissertation is chiefly concerned with
articulating the relationship between poetic form, history, and authority in this body
of' work. Howe's poetry dredges the past for the linguistic effects of patriarchy,
colonialism and war. My reading of the work is an exploration of the ways in which a
disjunctive poetics can address such historical trauma. The poems, rather than
attempting to reinstate voices lifted from what Howe has called "the dark side of
history", are a means of reflecting the resistance that the past offers to contemporary
investigation. It is the effacement, and not the recovery, of history's victims, that is
discernible in the contours of these highly opaque texts. Notions of authority are most
often addressed in the poetry through the figure of paternal absence, which has a
threefold function in the work, serving to represent social authority, an aporetic
conception of divinity and an autobiographical narrative. Alongside the antiauthoritarian
currents in the writing - critiques, for example, of the doctrine of
Manifest Destiny or of scapegoating versions of femininity - my thesis stresses Howe's
engagement with negative theology and with a strain of American Protestant
enthusiasm that has its roots in 17th century New England. The dissertation explores
the dissonance caused by the co-existence in the poetry of elements of political dissent
and religious mysticism. Finally, I consider Howe's engagement with literary history
and authors such as Shakespeare, Swift, Thoreau and Melville. The manner in which
Howe deploys the words of others in her work, I argue, allows for a mixture of textual
polyphony and a more conventional notion of authorial 'voice'
Improved heart rate recovery despite reduced exercise performance following heavy training: a within-subject analysis
No full textAbstract not availableRebecca L. Thomson, Clint R. Bellenger, Peter R.C. Howe, Laura Karavirta, Jonathan D. Buckle
Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18 years old. The 1993 Pelotas Birth Cohort
No full textAbstract not availableJeovany Martínez-Mesa, Ana Maria Baptista Menezes, Laura D. Howe, Fernando Cesar Wehrmeister, Ludmila Correia Muniz, David Alejandro González-Chica, Maria Cecilia Assunção, Helen Gonçalves, Fernando C. Barro
sj-pdf-1-jiv-10.1177_0886260520935096 – Supplemental material for The Clustering of Adverse Childhood Experiences in the Avon Longitudinal Study of Parents and Children: Are Gender and Poverty Important?
No full textSupplemental material, sj-pdf-1-jiv-10.1177_0886260520935096 for The Clustering of Adverse Childhood Experiences in the Avon Longitudinal Study of Parents and Children: Are Gender and Poverty Important? by Rebecca E. Lacey, Laura D. Howe, Michelle Kelly-Irving, Mel Bartley and Yvonne Kelly in Journal of Interpersonal Violence</p
sj-pdf-1-jiv-10.1177_08862605221087708 – Supplemental Material for Categories of Intimate Partner Violence and Abuse Among Young Women and Men: Latent Class Analysis of Psychological, Physical, and Sexual Victimization and Perpetration in a UK Birth Cohort
No full textSupplemental Material, sj-pdf-1-jiv-10.1177_08862605221087708 for Categories of Intimate Partner Violence and Abuse Among Young Women and Men: Latent Class Analysis of Psychological, Physical, and Sexual Victimization and Perpetration in a UK Birth Cohort by Annie Herbert, Abigail Fraser, Laura D. Howe, Eszter Szilassy, Maria Barnes, Gene Feder, Christine Barter and Jon Heron in Journal of Interpersonal Violence</p
Nonlinear Exposure-Outcome Associations and Public Health Policy
No full textAbigail Fraser, Debbie A. Lawlor, Laura D. How
Does vitamin D mediate the protective effects of time outdoors on myopia? Findings from a prospective birth cohort
No full textPurpose: More time outdoors is associated with a lesser risk of myopia, but the underlying mechanism is unclear. We tested the hypothesis that 25-hydroxyvitamin D (vitamin D) mediates the protective effects of time outdoors against myopia. Methods: We analyzed data for children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) population-based birth cohort: noncycloplegic autorefraction at age 7 to 15 years; maternal report of time outdoors at age 8 years and serum vitamin D2 and D3 at age 10 years. A survival analysis hazard ratio (HR) for incident myopia was calculated for children spending a high- versus low-time outdoors, before and after controlling for vitamin D level (N = 3677). Results: Total vitamin D and D3, but not D2, levels were higher in children who spent more time outdoors (mean [95% confidence interval (CI)] vitamin D in nmol/L: Total, 60.0 [59.4-60.6] vs. 56.9 [55.0-58.8], P = 0.001; D3, 55.4 [54.9-56.0] vs. 53.0 [51.3-54.9], P = 0.014; D2, 5.7 [5.5-5.8] vs. 5.4 [5.1-5.8], P = 0.23). In models including both time outdoors and sunlight-exposure-related vitamin D, there was no independent association between vitamin D and incident myopia (Total, HR = 0.83 [0.66-1.04], P = 0.11; D3, HR = 0.89 [0.72-1.10], P = 0.30), while time outdoors retained the same strong negative association with incident myopia as in unadjusted models (HR = 0.69 [0.55-0.86], P = 0.001). Conclusions:Total vitamin D and D3 were biomarkers for time spent outdoors, however there was no evidence they were independently associated with future myopia.Jeremy A. Guggenheim, Cathy Williams, Kate Northstone, Laura D. Howe, Kate Tilling, Beate St Pourcain, George McMahon and Debbie A. Lawlo
Effects of Moritella viscosa antigens on pro-inflammatory gene expression in an Atlantic salmon (Salmo salar Linnaeus) cell line (SHK-1)
No full textMoritella viscosa is the causative agent of winter ulcer disease in salmonids reared in North-Atlantic countries. In this study the effects of selected M. viscosa antigens on cytotoxicity and pro-inflammatory gene expression in an Atlantic salmon (Salmo salar Linnaeus) macrophage-like cell line (SHK-1) were examined. SHK-1 cells were stimulated with live and heat-killed bacterial cells, extracellular products (ECP) and an extracellular vibriolysin, termed MvP1. Following incubation, cytotoxicity and expression levels of interleukin-1β (IL-1β) and interleukin-8 (IL-8) were examined at different time points. Both live M. viscosa cells and ECP were cytotoxic, but neither heat-killed cells, nor the MvP1 peptidase caused cell death. Expression levels of both IL-1β and IL-8 increased significantly after stimulation with live cells, but heat-killed cells only caused increased IL-8 expression. ECP did not affect IL-1β expression, but did stimulate IL-8 expression. The isolated MvP1 peptidase stimulated both IL-1β and IL-8 expression at the highest concentration tested. This study reveals a difference in the induction of pro-inflammatory gene expression in salmon SHK-1 cells between live and heat-killed M. viscosa cells, and also that an unknown secreted factor is the main stimulant of IL-β and IL-8 expression.ID: S1050464809000990; M3: Article; Accession Number: S1050464809000990; Author: Bryndis Bjornsdottir (a, b); Author: Mark D. Fast (b, 1); Author: Sandra A. Sperker (b); Author: Laura L. Brown (b, 2); Author: Bjarnheidur K. Gudmundsdottir (a, ∗); Affiliation: Institute for Experimental Pathology, University of Iceland, Keldur v/Vesturlandsveg, 112 Reykjavík, Iceland; Affiliation: National Research Council Canada, Institute for Marine Biosciences, 1411 Oxford Street, Halifax, Nova Scotia B3H 2Z1, Canada; Keyword: Moritella viscosa; Keyword: Extracellular products; Keyword: MvP1 vibriolysin; Keyword: Atlantic salmon; Keyword: SHK-1; Keyword: Gene expression; Keyword: Immune response; Keyword: Pro-inflammatory cytokine; Keyword: Interleukin-1β (IL-1β); Keyword: Interleukin-8 (IL-8); Number of Pages: 6; Language: English;Source type: Electronic(1
Go Big or Go Home: Priorities for the Canada-EU Economic and Trade Agreement
No full textA comprehensive economic and trade agreement (CETA) between Canada and the European Union (EU) is both desirable and possible. For Canada, an agreement with the EU is a strategic opportunity to significantly diversify the market for its high-value-added goods, services and skills, to increase the attractiveness of its economy for investors, and to make a statement that it is ready to engage with other important trade partners on reducing barriers to mutually beneficial trade and investment. This is important in light of both the failure of the Doha round of WTO talks and the existence of other important trade negotiations undertaken by Canada’s key trade partners.International Economic Policy, comprehensive economic and trade agreement (CETA), Canada, European Union (EU)
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