197 research outputs found
I. Carbonion- and Free Radical-Type Rearrangements in Homoallylic Systems. II. Nuclear Magnetic Resonance in Cyclopropanes
No full textI. A study was made of the Grignard and free-radical reactions of vinyl-and phenyl-substituted allyl-carbinyl derivatives. Cyclopropylcarbinyl products were obtained in both types of reactions for the ([...]-vinylallyl)-carbinyl and ([...], [...]-diphenylallyl)-carbinyl systems, and evidence was obtained bearing on the intermediates involved
in some of these rearrangements.
II. Analysis of the nuclear magnetic resonance spectra of a number of cyclopropanes yielded data in the form of spin-spin coupling constants and chemical shifts. This information was correlated with existing theories on molecular structure and on the electronic structure of
cyclopropanes. The chemical shifts for several cyclopropane hydrocarbons were interpreted in part in terms of a cyclopropane ring current effect.</p
"Thank me therefore": Social Prestige, Probity and Self-determination of Nymue's character in Malory's "Le Morte Darthur"
No full textSuperCLASS – I. The super cluster assisted shear survey: Project overview and data release 1
No full text\ua9 2020 The Author(s).The SuperCLuster Assisted Shear Survey (SuperCLASS) is a legacy programme using the e-MERLIN interferometric array. The aim is to observe the sky at L-band (1.4 GHz) to a r.m.s. of 7 μJy beam−1 over an area of ∼ 1 deg2 centred on the Abell 981 supercluster. The main scientific objectives of the project are: (i) to detect the effects of weak lensing in the radio in preparation for similar measurements with the Square Kilometre Array (SKA); (ii) an extinction free census of star formation and AGN activity out to z ∼ 1. In this paper we give an overview of the project including the science goals and multiwavelength coverage before presenting the first data release. We have analysed around 400 h of e-MERLIN data allowing us to create a Data Release 1 (DR1) mosaic of ∼ 0.26 deg2 to the full depth. These observations have been supplemented with complementary radio observations from the Karl G. Jansky Very Large Array (VLA) and optical/near infrared observations taken with the Subaru, Canada-France-Hawaii, and Spitzer Telescopes. The main data product is a catalogue of 887 sources detected by the VLA, of which 395 are detected by e-MERLIN and 197 of these are resolved. We have investigated the size, flux, and spectral index properties of these sources finding them compatible with previous studies. Preliminary photometric redshifts, and an assessment of galaxy shapes measured in the radio data, combined with a radio-optical cross-correlation technique probing cosmic shear in a supercluster environment, are presented in companion papers
LeMMINGs III. The e-MERLIN legacy survey of the Palomar sample: exploring the origin of nuclear radio emission in active and inactive galaxies through the [O iii] – radio connection
No full textWhat determines the nuclear radio emission in local galaxies? To address this question, we combine optical [O iii] line emission, robust black hole (BH) mass estimates, and high-resolution e-MERLIN 1.5-GHz data, from the LeMMINGs survey, of a statistically complete sample of 280 nearby optically active (LINER and Seyfert) and inactive [H ii and absorption line galaxies (ALGs)] galaxies. Using [O iii] luminosity (L[O III]) as a proxy for the accretion power, local galaxies follow distinct sequences in the optical-radio planes of BH activity, which suggest different origins of the nuclear radio emission for the optical classes. The 1.5-GHz radio luminosity of their parsec-scale cores (Lcore) is found to scale with BH mass (MBH) and [O iii] luminosity. Below MBH ∼106.5 M⊙, stellar processes from non-jetted H ii galaxies dominate with Lcore ∝ MBH0.61 ± 0.33 and Lcore ∝ L[O III]0.79 ± 0.30. Above MBH ∼106.5 M⊙, accretion-driven processes dominate with Lcore ∝ MBH1.5-1.65 and Lcore ∝ L[O III]0.99-1.31 for active galaxies: radio-quiet/loud LINERs, Seyferts, and jetted H ii galaxies always display (although low) signatures of radio-emitting BH activity, with L1.5 GHz ≳ 1019.8 W Hz-1 and MBH ≳ 107 M⊙, on a broad range of Eddington-scaled accretion rates (m). Radio-quiet and radio-loud LINERs are powered by low-m discs launching sub-relativistic and relativistic jets, respectively. Low-power slow jets and disc/corona winds from moderately high to high-m discs account for the compact and edge-brightened jets of Seyferts, respectively. Jetted H ii galaxies may host weakly active BHs. Fuel-starved BHs and recurrent activity account for ALG properties. In conclusion, specific accretion-ejection states of active BHs determine the radio production and the optical classification of local active galaxies. © 2021 The Author(s) Published by Oxford University Press on behalf of Royal Astronomical Society
A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours
No full text\ua9 2019, The Author(s). Background: Combined focal adhesion kinase (FAK) and MEK inhibition may provide greater anticancer effect than FAK monotherapy. Methods: This dose-finding phase Ib study (adaptive 3 + 3 design) determined the maximum tolerated dose (MTD) of trametinib and the FAK inhibitor GSK2256098 in combination. Eligible patients had mesothelioma or other solid tumours with probable mitogen activated protein kinase pathway activation. Adverse events (AEs), dose-limiting toxicities, disease progression and pharmacokinetics/pharmacodynamics were analysed. Results: Thirty-four subjects were enrolled. The GSK2256098/trametinib MTDs were 500 mg twice daily (BID)/0.375 mg once daily (QD) (high/low) and 250 mg BID/0.5 mg QD (low/high). The most common AEs were nausea, diarrhoea, decreased appetite, pruritus, fatigue and rash; none were grade 4. Systemic exposure to trametinib increased when co-administered with GSK2256098, versus trametinib monotherapy; GSK2256098 pharmacokinetics were unaffected by concomitant trametinib. Median progression-free survival (PFS) was 11.8 weeks (95% CI: 6.1–24.1) in subjects with mesothelioma and was longer with Merlin-negative versus Merlin-positive tumours (15.0 vs 7.3 weeks). Conclusions: Trametinib exposure increased when co-administered with GSK2256098, but not vice versa. Mesothelioma patients with loss of Merlin had longer PFS than subjects with wild-type, although support for efficacy with this combination was limited. Safety profiles were acceptable up to the MTD
Literature and cultural pluralism : East Indians in the Caribbean
No full textThis study explores the position, of imaginative literature
in the ethnically plural societies of Trinidad and Guyana in
the Caribbean. It examines the extent to which the production of imaginative literature has been marked by the same ethnic divisions which have bedevilled the political, social and cultural life of these societies. For reasons explained in Chapter One, the study focuses mainly on the literature by writers from and about the Indian section of the population.
However, the study is concerned not only with the way that
the context of ethnic and cultural fragmentation has affected a good deal of the writing produced in these societies, but also with the smaller number of works, mainly of fiction, which contribute to a much-needed understanding of these societies by bringing the lives of both major groups into a common focus. I argue that it is not enough to describe the differences between the two types of writing merely in terms of the presence or absence of ethnocentric biases, and discuss both the conceptual frameworks within which works of fiction may be felt to give'truthfullknowledge and the conventions of representation which most effectively communicate that knowledge to the reader.
The thesis is divided into four sections. The first develops
the argument that in much of the fiction examined there
has been a connexion between ethnocentric biases, an empiricist epistemology and conventions of representation which are defined later as naturalistic. Parts Two and Three present a detailed examination of this proposition by analysing the works of Indian and non-Indian authors. The fourth part discusses those novels which go beyond the presentation of ethnically fragmented images by constructing fictive worlds which attempt to encompass the social whole. Such novels are shown to have a self-awareness of their epistemological and cultural assumptions,
and in some cases an awareness that the real but hidden
structures of society may only be incompletely or falsely
experienced by the novel's characters. I show that such concerns with attempting to portray the real social whole, frequently intersect with an intense involvement, on the part of the author, with the aesthetic structuring and verbal texture of the novel
The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel
No full textBackground: Versutoxin (delta-ACTX-Hv1) is the major component of the venom of the Australian Blue Mountains funnel web spider, Hadronyche versuta. delta-ACTX-Hv1 produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of voltage-gated sodium channels; delta-ACTX-Hv1 is therefore a useful tool for studying sodium channel function. We have determined the three-dimensional structure of delta ACTX-Hv1 as the first step towards understanding the molecular basis of its interaction with these channels. Results: The solution structure of delta-ACTX-Hv1, determined using NMR spectroscopy, comprises a core beta region containing a triple-stranded antiparallel beta sheet, a thumb-like extension protruding from the beta region and a C-terminal 3(10) helix that is appended to the beta domain by virtue of a disulphide bond. The beta region contains a cystine knot motif similar to that seen in other neurotoxic polypeptides. The structure shows homology with mu-agatoxin-l, a spider toxin that also modifies the inactivation kinetics of vertebrate voltage-gated sodium channels. More surprisingly, delta-ACTX-Hv1 shows both sequence and structural homology with gurmarin, a plant polypeptide. This similarity leads us to suggest that the sweet-taste suppression elicited by gurmarin may result from an interaction with one of the downstream ion channels involved in sweet-taste transduction. Conclusions: delta-ACTX-Hv1 shows no structural homology with either sea anemone or alpha-scorpion toxins, both of which also modify the inactivation kinetics of voltage-gated sodium channels by interacting with channel recognition site 3. However, we have shown that delta-ACTX-Hv1 contains charged residues that are topologically related to those implicated in the binding of sea anemone and alpha-scorpion toxins to mammalian voltage-gated sodium channels, suggesting similarities in their mode of interaction with these channels
Obstacles on the path: An exposition of the experience of car-free living
No full textThe contemporary focus by local and central government on the promotion of sustainable transport options has highlighted the need for commuting to move away from the current dependence on private cars to more public and active (walking and cycling) modes of transport. Given the prominence of the motor car in personal transport options however, choosing to live car-free in this car dependent culture appears at first glance to be an irrational choice. This research explores the lived experiences of a group of Hamilton residents who have made such a choice. Using a grounded theory approach, the thesis presents the results of interviews with nine car-free Hamilton residents who shared their personal transport stories, which include their childhood experiences, but focus on their current everyday practices and experiences. Through semi-structured interviews, the costs and benefits of a car-free lifestyle are articulated and analysed. Their motivations for choosing to forgo cars and their solutions for overcoming potential barriers to car-free living are also reported and explored. The collected data generated a range of themes which are presented in three chapters, each covering a specific aspect of the participants’ stories. The first group of themes relate to the public sphere, the second to the private realm and the final group emanates from specific elements of car-free living that the thesis sought to clarify through the participants’ stories. The key finding is that living car-free within Hamilton City is viewed by the participants as a well reasoned and eminently sensible choice, which produces multiple benefits. In addition to their reduced environmental footprints, the participants value the social interaction associated with active and public transport. Their consensus is that they are healthier, wealthier and more involved members of the community. The most problematic areas of living without a car were associated with recreational and social activities, which often do not coincide with public transport schedules or involve distances too great for active transport. The benefits far outweigh any disadvantages however, and ultimately, this thesis concludes that a motor car is not necessary for the everyday activities of urban living in Hamilton and any associated inconveniences are not as insurmountable as generally imagined
The rise and fall of the Labour league of youth
No full textThis thesis charts the rise and fall of the Labour Party’s first and most enduring youth organisation, the Labour League of Youth. The history of the League, from its birth in the early nineteen twenties to its demise in the late nineteen fifties, is placed in the context of the Labour Party’s subsequent fruitless attempts to establish and maintain a vibrant and functional youth organisation. A narrative is incorporated that illuminates the culture, organisation and political activism of the League and establishes it as a predominantly working class radical organisation. The reluctance on the part of the Labour Party to grant autonomy to its youth sections resulted in the history of the League of Youth being one of control, suppression and tension. This state of affairs ensured that subsequent youth groups, the Young Socialists and Young Labour, would be established in an atmosphere of reservation and scepticism.
The thesis places the prime responsibility for the failure of the party’s youth organisations with the party leadership but also considers the contributory factors of changing social and political circumstances. A number of themes are explored which include the impact of structure and agency factors, the power of the Parliamentary Labour Party, the political socialisation of leading figures within the party, the social context in which each of the groups emerged and the extent to which the youth groups were prey to intra-party factionalism.
The thesis redresses the balance of research where most accounts have focussed on the Young Socialists and traces the common characteristics that are prevalent in the way the party leadership has approached its relationship with its youth organisations. Use has been made of previously unpublished primary source material, the major source being the League of Youth members themselves whose recollections have helped to demonstrate the arguments put forward in this thesis
A soldier of the legion lay dying in Algiers,
No full textvoiceContinued by Binghin on the Rhine (cont.)Collected by Merlin Mitchell
Transcribed by Kyle Perrin
Mrs. Bement
Springdale, Ark.
April 19, 1950
Binghin on the Rhine
A soldier of the legion lay dying in Algiers,
There was lack of woman's nursing, derth of woman's tears,
A comrad stood beside him as Ma life-blood ebbed away,
AND death with fleeing glances to hear what he might say.
The dying soldier faultered as he took that comrad's hint,
And said, I never more shall see my own, my native land,
Take a message and a token to some distant friends of nine,
For I was born at Binghin, at Binghin on the Rhine.
Tell my brothers and companions when they meet and crowd around
To them I . . . mournful stories(?) in the pleasant vinyard brown(?),
That we fought the battle bravely and when the day was done,
Full many a-corpse lay ghastly pale beneath the setting sun.
Amidst the dead and dying were some grown old in wars,
Who . . . the last of many scars,
But some were young and suddenly beheld l i f e ' s morn decline,
And wounded come from Binghin, from Binghin on the Rhine.
Tell my mother that her other sons shall comfort her old age,
And I was a trooper that thought his home a cage,
For my father was a soldier and even as a child,
My heart leaped for to hear him tell of struggles fierce and wild.
And when he died and l e f t us to divide his scanty hoard,
I let them take whate'er they would but kept my father's sword,
And my boyish . . . the bright light use to shine,
On the cottage at fair Binghin, fair Binghin on the Rhine.
Tell my sister not to weep o'er me and sob with drooping head,
When the troops are marching home again with glad and galant tread,
But to look upon them proudly with a calm, steadfast eye,
or her brother was a soldier, too, and not afraid to die.
And i f a comrad seek her love, why ask her my name,
To lock upon him proudly without regret or shame,
And to hang the old SWORD in its place, my father's sword and mine,
Far down(?) in old Binghin, dear Binghin on the Rhine.
There's another, rot a sister, in happy days gone by,
You're to know her by the . . . that sparkled in her eye,
Who the simple coquetry to f a l l for bridal scorning,
Oh, friends, I fear the lightest heart makes sometimes heaviest mourning.
**The next three verses are also found on reel 40.
***The remainder of the song is found on reel 40.
Reel 39
Item (more)
Binghin on the Rhine (Cont.)
Tell her the last night of my l i f e 'fore e'er the noon be risen,
My body will be out of pain, my soul be out of prison,
I dreamed I stood with her and saw the yellow sunlight shine,
On the fine paths(?) of Binghin, f a i r Binghin on the Rhine.
I saw the blue Rhine sweep a l o n g ( ? ) , I heard or seemed to hear,
The Germans all they use to sing in chorus sweet and clear,
And on the plaza clean(?) and up the slanting h i l l,
The echoing chorus sounded through the evening calm and s t i l l .
And her glad blue eyes were on me as we passed with friendly talk,
The many a-path belong to yore and well remembered walk,
And her l i t t l e hand lay lightly, invitingly in mine,
I looked no more at Binghin, at Binghin on the Rhine.
His voice grew faint and courser, his grasp was childish weak,
His eyes put on a dying look, he sighed but ceased to speak,
A comrad bent to l i f t him but the spark of l i f e had fled,
The soldier of the ligion in a foreign land was dead.
And the soft moon rose up slowly and coldly she looked down,
On the wreched and bloody(?) battlefield with bloody corpses strewn,
Yea, come she on that dreadful scene, her pale light seemed to shine,
As she shown can distant Binghin, f a i r Binghin on the Rhine.
Mitch..Who's the author of that song?
Mrs.B..A Mistress Norton. It's in such fine print—Mistress Norton,
Caroline Elizabeth Sheridan was granddaughter of Richard Greenly
Sheridan—
Mitch..Is the date of the song given?
Mrs. B..No, but the Germans have been fighters all these years, you know.
This is printed in I860. I don't know how Iong this happened
before that, Well, one, I suppose, Just composed i t . If you
could read it—if you want to read that latter part there—
I t ' s in such fine print that I can't read i t.Funding for digitization provided by the Arkansas Humanities Council and the Happy Hollow Foundation
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