265,715 research outputs found
δ Orionis: Further temporal variability and evidence for small-scale structure in the interstellar medium
No full textWe report here the detection of both spatial and temporal variations in interstellar absorption in the line of sight to δ Orionis. First, we present new high-resolution (R≈110 000) observations of the interstellar D lines of Na i towards both δ Ori A and C. Comparison of these spectra highlights variations in absorption between the two stars, indicative of small-scale spatial structure in the interstellar medium in this direction over distances of less than ≈15 000 au (the projected separation of the two stars). Components with the largest Na i column densities and lowest velocity dispersions are, in general, found to be subject to the greatest differences; in fact the narrowest component detected is only observed in one of the sightlines. This effect has also been reported by Meyer & Blades. Secondly, we present new ultra-high-resolution (R≈900 000) Na i D1 observations and high-resolution (R≈110 000) Ca ii H & K observations of δ Ori A which, through ultra-high-resolution work conducted between 1994 and 2000, has been shown to exhibit a time-variable interstellar Na i absorption component. These new observations, while revealing the further reduction in intensity of the time-variable Na i absorption, indicate constant Ca ii absorption over the same period. This results in a dramatic reduction in the Na°/Ca+ abundance ratio, perhaps indicating the line of sight to be gradually probing a less-dense outer region of an absorbing filament
Usborne First Reading
No full textThis is my first find in a series of -- apparently -- sixteen First Reading books by Usborne including three fables. All sixteen are pictured on the endpapers. I have ordered TMCM and GGE from the same series. This is a sturdy book, about 8 x 5, containing 48 pages. This telling highlights Harry Hare's ugly boasting. He is a delivery man by trade. He trains hard for the race; in fact, his over-training seems to lead to his tiredness along the way. He actually decides to have a nap in this version. The book seems to me typical of Usborne in the charming way Howarth fills out each picture with small animals going about their various tasks. Good examples include the hedgehog accountant on 10 and 11, the weasel (?) announcer perched in a tree branch on 27, and the skateboarding mouse on 35. Pages 44-46 give a short introduction to fables.This is a hardbound book (hard cover)Retold by Mairi Mackinno
Letter Written by James Bertram Howarth to the Bryant College Service Club Dated April 6, 1944
No full text[Transcription begins]
UNITED STATES NAVYStoughton S-14Nav. Tra. Scol (Comm.)Harvard UniversityCambridge, Mass.6 April 1944
Dear friends,
Again I am indebted to you for another kindness bestowed, and would like to express my sincere appreciation. The tobacco arrived yesterday in good condition.
My course here at Harvard ends in another month. We have leave for approximately two weeks before reporting to our Naval District to pick up our orders. They claim that we may work under temporary duty for a short time in the home district (Boston is mine) before being shipped out. I will endeavor to keep you informed of my adventures, and if at all possible, will call at Bryant, the early part of May.
Again let me thank you for the package, and remember me to all the staff and faculty.
As ever,J. B. Howarth
[Transcription ends
Letter Written by James Bertram Howarth to the Bryant College Service Club Dated June 11, 1943
No full text[Transcription begins]UNITED STATES NAVY308 W. 37th StreetNorfolk 8, Va.June 11, 1943
Dear friends at Bryant,
This will acknowledge and also thank you most sincerely for your thoughtful gift of cigarettes received yesterday. These remembrances serve to keep a warm place in one’s heart for Bryant and the many friends and former associates of mine on the hill.
Kindly note the change of address as I succeeded in finding a residence here in a Norfolk suburb and now have my wife with me.
Remember me to Mr. Gardiner Jacobs and tell him I will write from time to time; also say “hello” to Mr. Ripley, Rita and Florence as they are about all that remain of the “old gang.” (Include George Richards, please).
Again, thank you for your kindness and thoughtfulness.
SincerelyJ. B. Howarth[Transcription ends
Letter Written by James Bertram Howarth to the Bryant College Service Club Dated March 7, 1943
No full text[Transcription begins]UNITED STATES NAVYStoughton S-14Nav Tra Scol (Comm.)Harvard UniversityCambridge, Mass.3/7/43
Dear friends,
This is to inform you of change of address. I was detached from the Norfolk Navy Yard on February 20 and reported here March 1 after spending almost ten months in Virginia.
This course in Communications fitting us for sea duty or advanced base work is specialized and will last approximately three to four months; therefore, you can send any data to the above address until July 1.
Lt. Shors wanted to be remembered to you all. He was assisting the officers at the Yard with their Income Tax problems when I left, and completed mine just before my detachment.
Say hello to Mr. Gardner Jacobs, Mr. Ripley, Rita, George Richards and any of the old regime.
Sincerely,Ens. J. B. Howarth[Transcription ends
A peptide filtering relation quantifies MHC class I peptide optimization
No full textMajor Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to protein fragments arising from intracellular protein turnover and presenting these fragments at the cell surface. Competing fragments (peptides) are selected for cell-surface presentation on the basis of their ability to form a stable complex with MHC class I, by a process known as peptide optimization. A better understanding of the optimization process is important for our understanding of immunodominance, the predominance of some T lymphocyte specificities over others, which can determine the efficacy of an immune response, the danger of immune evasion, and the success of vaccination strategies. In this paper we present a dynamical systems model of peptide optimization by MHC class I. We incorporate the chaperone molecule tapasin, which has been shown to enhance peptide optimization to different extents for different MHC class I alleles. Using a combination of published and novel experimental data to parameterize the model, we arrive at a relation of peptide filtering, which quantifies peptide optimization as a function of peptide supply and peptide unbinding rates. From this relation, we find that tapasin enhances peptide unbinding to improve peptide optimization without significantly delaying the transit of MHC to the cell surface, and differences in peptide optimization across MHC class I alleles can be explained by allele-specific differences in peptide binding. Importantly, our filtering relation may be used to dynamically predict the cell surface abundance of any number of competing peptides by MHC class I alleles, providing a quantitative basis to investigate viral infection or disease at the cellular level. We exemplify this by simulating optimization of the distribution of peptides derived from Human Immunodeficiency Virus Gag-Pol polyprotein
Josephiella Matsunaga & Howarth & Kumashiro 2019, n. sp.
No full text<i>Josephiella</i> n. sp. A (apparently undescribed) <p> <b>NEW STATE RECORD</b></p> <p> An agaonid wasp new to science was discovered causing galls on the stems of <i>Ficus microcarpa</i>. Terminal stems of affected trees appeared unhealthy with a sparse foliar canopy. Initial observers of this damage were under the assumption that the same species which causes leaf galling on <i>F. microcarpa</i> (<i>Josephiella microcarpae</i>) was also causing the galling on stems of the same plant. However, closer examination of the stem-galling wasps showed that while both the leaf-galler and the stem-galler are morphologically similar in many ways, this in fact may be a different species. Both leaf and stem-gallers can be found on the same plant. Jean-Yves Rasplus, co-author of the leaf-galling <i>J. microcarpae</i>, agreed that this could be an undescribed species and is currently working on its species description.</p> <p> Subsequent to the initial discovery of this stem-galler on Oahu in 2012, infested <i>F. microcarpa</i> were quickly noted on Hawaii and Maui. In May, 2016, galled <i>F. microcarpa</i> stems with exit holes were collected from Molokai and in July, 2017, from Kauai. However, material from these islands were too old and no adults could be recovered. Therefore, we do not list the collection data below, and in the list of new species we noted a question mark next to these islands until the adults are confirmed. <i>Josephiella</i> n. sp. A, along with <i>Josephiella microcarpae</i>, lobate lac scale (<i>Paratarchardina pseudolobata</i>), and other ficus-feeding species has contributed to the weakening of large banyan trees on Oahu.</p> <p> <b>Collection records: OAHU</b>, Manoa, 13.VII.2012, ex. <i>Ficus microcarpa</i> stems, coll. D. Hulbert, det. J.-Y. Rasplus, 6.X.2012.</p> <p> <b>HAWAII</b>, Hilo, 30.VII.2012, ex. <i>F. microcarpa</i> stems, coll. C. Hirayama, L. Larish & S. Chun, det. B. Kumashiro, VIII.2012.</p> <p> <b>MAUI</b>, Wailuku, 6.VIII.2012, ex. <i>F. microcarpa</i> stems, coll. M. Fukada, VIII.2012. Vouchers at HDOA.</p>Published as part of <i>Matsunaga, Janis N., Howarth, Francis G. & Kumashiro, Bernarr R., 2019, New State Records and Additions to the Alien Terrestrial Arthropod Fauna in the Hawaiian Islands, pp. 1-71 in Proceedings of the Hawaiian Entomological Society 51 (1)</i> on pages 11-12, DOI: <a href="http://zenodo.org/record/10832895">10.5281/zenodo.10832895</a>
Letter Written by James Bertram Howarth to the Bryant College Service Club Dated June 16, 1944
No full text[Transcription begins]UNITED STATES NAVY1918 N. Street, N. W.Washington, D. C.16 June 1944
Dear friends,
Greetings from Washington where I am undergoing some specialized training for work attached to the Pacific fleet. There are ten Harvard men in this unit and we will operate from some major base although connected with the fleet. We have had a refresher course for these first two weeks, and now break up and go to work thorugh the different Comm. departments. One must have a knowledge of all phases of communications for this duty; therefore, we will be here for at least three months before shipping out.
Before coming to Washington, I spent two and a half weeks at Headquarters in Boston so believe this brings my activities up to date. Incidentally my promotion to Lt.(jg) came through on the first of May.
Hope to have some leave before shipping out this fall, and if possible will call at the office. Remember me to all.
Sincerely,J. Bertram Howarth[Transcription ends
Letter Written by James Bertram Howarth to the Bryant College Service Club Dated December 15, 1943
No full text[Transcription begins]UNITED STATES NAVY
308 W. 37th StreetNorfolk 8, VirginiaDecember 15, 1943
Dear friends of Bryant Service Club,
This will acknowledge with many thanks your Christmas package which was received this week, and also your recent letter which has been read with interest and enthusiasm. You are certainly doing a fine job, and I, for one, am grateful. Your kind thoughts and interest in the Service men, I know, will always be remembered.
I have met Lieut. Shors, and have an invitation to his home, but as yet have been unable to accept. He logged out in this office before his last leave, and upon his return, he told me that several of the “old timers” had asked about me and my work.
So Mr. Naylor has at last gone “out of circulation.” I feel very kindly toward this gentleman as he was a close friend and adviser to my nephew, George Scothon, who is now in the Finance Detachment in Australia. He was a member of the Faculty when I attended Bryant, but do not think he would remember me after all these years.
Did you get the inside story on the escape of Lieut. Wesley Crawley from the Germans? I received a copy of a letter written to his father, and believe me it was something to read. Perhaps they (his family) would send you the excerpt of the report if you so desire.
I have eight day’s leave commencing December 20, and if possible will call at the office before Christmas or will you all be away for the holidays?
Please say “hello” to Gardner Jacobs, Mr. Ripley, George Richards, and Rita; also, any other members of the faculty and staff who may remember the days of 1934-36.
Thank you again, and may I wish you all a very Merry Christmas and a most Prosperous New Year.
Yours for Victory,JB Howarth[Transcription ends
Chrysozephyrus tytleri subsp. tytleri tytleri (Howarth 1957
No full text<p> 127. <i>Chrysozephyrus tytleri tytleri</i> (Howarth, 1957)</p> <p>Published records: Howarth, 1957: 249; Van Gasse, 2013; Varshney & Smetacek, 2015: 99.</p> <p>Remarks: Not recorded during the study.</p>Published as part of <i>Irungbam, Jatishwor Singh, Meitei, Laishram Ricky, Huidrom, Harmenn, Soibam, Baleshwor Singh, Ngangom, Aomao, Ngangom, Bendang, Meitei, Ronald & Fric, Zdenek Faltynek, 2020, An Inventory Of The Butterflies Of Manipur, India (Insecta: Lepidoptera), pp. 1-91 in Zootaxa 4882 (1)</i> on page 37, DOI: 10.11646/zootaxa.4882.1.1, <a href="http://zenodo.org/record/4296011">http://zenodo.org/record/4296011</a>
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