8,249 research outputs found
Haitian Landscape with Ra Ra Band
No full textRa Ra band and people walking up a mountain toward a man on a white horse in the lower left; Ra Ra bands travel the country during Lent and, on Good Friday, they assemble in the coastal town of Leogane, where they perform and the best Ra Ra band is chosen - framedhttps://dh.howard.edu/mayaangelou_audio/1000/thumbnail.jp
Retinoid and carotenoid angiogenesis: A possible explanation for enhanced oral carcinogenesis
No full textThe carotenoids β-carotene and canthaxanthin and the retinoid 13-cis- retinoic acid (13-RA) have inhibited oral carcinogenesis in the hamster cheek pouch (16 wks, 3 times/wk at 1.4 mg/kg) induced by an 0.5% solution of 7,12- dimethylbenz[a]anthracene (DMBA). However, 13-RA at a higher dose (\u3e2.0 mg/kg per treatment) increased squamous cell carcinoma growth (Eur J Cancer Clin Oncol 24, 839850, 1988). 13-RA, β-carotene, and canthaxanthin administered to 60 hamsters (16 wks, 3 times/wk, 10 mg/kg) altered neovascularization characterized by immunohistochemistry for transforming growth factor-α (TGF- α) and factor VIII. 13-RA + DMBA resulted in more smaller-sized tumors, with a reduced volume and tumor burden (tumor controls, 185.9; 13-RA + DMBA, 151.0). The carotenoids reduced the number and the sizes of the carcinomas formed (β-carotene, 60 tumors, 142.3 x 103 mm3; canthaxanthin, 30 tumors, 116.1 x 103 mm3). Factor VIII and TGF-α were expressed in high intensity at cancer sites of the 13-RA + DMBA and DMBA groups with \u3e50 and \u3e10 cells, respectively, per x400 field. In contrast, β-carotene- and canthaxanthin + DMBA treated pouches showed \u3e20 and 5 cells, respectively, per x400 field for factor VIII and TGF-α. These results suggest that 13-RA treatment may increase vascular growth, but the carotenoids also produced enhanced levels of endothelial cell growth and TGF-α compared with the untreated mucosa. The carotenoids may enhance tumor growth under the appropriate carcinogenic environment
Tabla genealógica de la familia Howard, duques de Norfolk. [Manuscrito]
No full textEmpieza en Roberto Howard.
Termina en su octavo nieto Enrique de Norfolk, hermano de doña Francisca Howard y Somerfet, casada con el III marqués de Valparaíso, Sebastián de Audín Irarrazábal.Pertenece a la Colección Salazar y Castro de la RA
Tabla genealógica de la familia Howard, duques de Norfolk. [Manuscrito]
No full textEmpieza en Roberto Howard.
Termina en su octavo nieto Enrique de Norfolk, hermano de doña Francisca Howard y Somerfet, casada con el III marqués de Valparaíso, Sebastián de Audín Irarrazábal.Pertenece a la Colección Salazar y Castro de la RA
Presentation and management of chronic pain
No full textChronic pain is an important clinical problem affecting significant numbers of children and their families. The severity and impact of chronic pain on everyday function is shaped by the complex interaction of biological, psychological and social factors that determine the experience of pain for each individual, rather than a straightforward reflection of the severity of disease or extent of tissue damage. In this article we present the research findings that strongly support a biopsychosocial concept of chronic pain, describe the current best evidence for management strategies and suggest a common general pathway for all types of chronic pain. The principles of management of some of the most important or frequently encountered chronic pain problems in paediatric practice; neuropathic pain, complex regional pain syndrome (CRPS), musculoskeletal pain, abdominal pain and headache are also described
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