9,740 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Ultrasound stimulates NF-κB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts.
No full textProton MR Spectroscopy of the Femoral Head ─ Evaluation of Patients at Risk for Avascular Necrosis.
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The two-spin model with dipolar interactions for the exchange coupled composite media
No full textWe study exchange coupled composite (ECC) media where both the hard and soft coupled layers possess perpendicular anisotropy or one of the layers is superparamagnetic. Our model is used to demonstrate the effect of the dipolar interactions on the coercive field. A series of ECC samples with various thicknesses of Ru spacer is manufactured and analyzed. The structure of the samples prepared is CoPtCr-SiO(2)/Ru/CoPtCr-SiO(2), with the composition varied around that of (CoPt(17)Cr(10))(90)-(SiO(2))(10). The acquired experimental data are used to illustrate the significance of magnetostatic interactions between the two coupled magnetic layers. (C) 2008 American Institute of Physics
Towards an ab initio description of correlated materials
No full textStrongly-correlated materials are a rich playground for physical phenomena, exhibiting complex phase diagrams with many competing orders. Ab initio insights into materials combined with physical ideas provide the ability to identify the organizing principles driving the correlated electronic behavior and pursue first-principles design of new compounds. Realistic modeling of correlated materials is an active area of research, especially with the recent merger of density functional theory (DFT) with dynamical mean-field theory (DMFT). This thesis is structured in two parts. The first describes the methods and algorithmic developments which drive advances in DFT+DMFT. In Ch. 2 and 3, we provide an overview of the two foundational theories, DMFT and DFT. In the second half of Ch. 3, we describe some of the principles guiding the combination of the two theories to form DFT+DMFT. In Ch. 4, we describe the algorithm lying at the heart of modern DFT+DMFT implementations, the hybridization expansion formulation of continuous-time quantum monte carlo (CTQMC) for the general Anderson impurity problem, as well as a fast rejection algorithm for speeding-up the local trace evaluation. The final chapter in the methods section describes an algorithm for direct sampling of the partition function, and thus the free energy and entropy, of simple Anderson impurity models within CTQMC. The second part of the thesis is a collection of applications of our emph{ab initio} approach to key correlated materials. We first apply our method to plutonium binary alloys (Ch. 6), which when supplemented with slave-boson mean-field theory, allows us to understand the observed photoemission spectra. Ch. 7 describes the computation of spectra and optical conductivity for rare-earth nickelates grown as epitaxial thin films. In the final two chapters, we turn our attention to the high-temperature superconductors. In the first, we show that the charge-transfer energy is a key chemical variable which controls the superconducting transition temperatures across the cuprate families. In the second, we extend this idea towards first-principles design of cuprates by exploring a new family of copper oxysulfides.}Ph. D.Includes bibliographical referencesby Chuck-Hou Ye
Variasi Kesalahan Pelafalan Konsonan Shejian Hou Yin oleh Siswa SD Kelas 1 Kingston School
No full textPermasalahan dalam penelitian adalah bagaimana variasi kesalahan pelafalan konsonan shejian hou yin oleh siswa SD kelas I Kingston School serta faktor penyebab terjadinya variasi kesalahan pelafalan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif yakni dengan memaparkan variasi kesalahan pelafalan konsonan shejian hou yin serta faktor penyebab terjadinya variasi kesalahan tersebut. Hasil penelitian menunjukkan dalam pelafalan konsonan shejian hou yin oleh subjek ditemukan 3 variasi kesalahan pelafalan konsonan zh, 1 variasi kesalahan pelafalan konsonan ch, 1 variasi kesalahan pelafalan konsonan sh dan 1 variasi kesalahan pelafalan untuk konsonan r, Penyebab terjadinya variasi kesalahan pelafalan konsonan shejian hou yin adalah faktor interlingual yaitu pengaruh bahasa ibu sebanyak 76 subjek penelitian dan faktor eksternal yaitu lingkungan keluarga sebanyak 5 subjek peuelitian
Hou ! les femmes : chansonnette répertoire Mayol [photographie de Félix Mayol créditée Panajou] [1911]
No full textHou ! les femmes : chansonnette ; (en-tête) “Répertoire Mayol” ; photographie de Félix Mayol créditée Panajou (série partition) ; paroles de Léognan ; musique de A. Valsien ; Veuve Charles Mayol éditeur, 10 rue de l’échiquier, Paris ; © by Ch[arles] Mayol (sans date) ; [intérieur : identique (départ, en-tête, éditeur adresse) ; ©1911 by V[eu]ve Ch[arles] Mayol ; sans (cotage, gravure, imprimerie)] ; verso catalogue Charles Mayol ; incipit “Tout’s les femm’s les blondes, les brun’s, les rousses / Quand on leur dit franch’ment : « J’ voudrais êtr’ votre amant »” ; titre inconnu du catalogue Opale-BNF ; datation (titre) 1911 ; datation (exemplaire) 1912. [Dépôt V1 médihal 14 septembre 2012
Chapter 144 - Intraoperative neurophysiology during spine and spinal cord surgery in children
No full textIntraoperative Neurophysiological Monitoring (IONM) has emerged over the past two decades as a discipline aimed not only to predict but also to prevent or minimize neurological morbidity through the intraoperative use of well-established neurophysiological techniques (Sala 2010)
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