31,748 research outputs found
Horton, Alicia D.
No full textcurrentPhD (Queen’s University)
MA (Queen’s University)
BA (Hon. 1st SFU)
Douglas College Faculty member since 2014.
Dr. Horton has experience with field research, participant observation and in-depth qualitative interviewing with hard to reach populations. Her research interests include prison culture, prison violence and conflict survival strategies, research ethics, body studies and popular criminology. Theoretical interest in gender and masculinities, symbolic interactionist, constructionist and social problems theories
beta 1 Integrin antisense oligodeoxynucleotides: utility in controlling osteoclast function
No full textThe involvement of beta 1 integrins in osteoclast function has been investigated by utilising an antisense oligodeoxynucleotide (ODN) approach. 18-mer antisense and control phosphorothioate ODNs mere made to a conserved internal region of beta 1 integrin sequence (nucleotide positions 1634-1651 of the human beta 1 fibronectin receptor), These were tested on rabbit osteoclasts for anti-adhesive and resorptive effects mediated by alpha V beta 3 and alpha 2 beta 1, the major integrins of osteoclasts. Antisense, but not control, beta 1 ODNs inhibited osteoclast adhesion to collagen-coated glass (by up to 70 %), but not to glass coated with vitronectin, fibronectin or fibrinogen, Adhesion to dentine and subsequent resorption mere also inhibited (up to 60 %) in a sequence-specific manner. The mechanism of action was verified using both a melanoma cell line, DX3, which expresses multiple integrins at high level including alpha V beta 3 and alpha 2 beta 1, and in a rabbit osteoclast marrow culture (BMC) system. Exposure of DX3 cells to antisense ODN for up to 48 hours reduced adhesion to FCS- and collagen-coated glass, and concomitantly inhibited beta 1 protein expression assessed by FACS and Western blot analysis; expression of other integrin subunits, alpha V and beta 3, was unaffected. Similarly the beta 1 protein levels in the BMC were reduced by >75 % without any effect on actin expression, These data reveal the utility of antisense ODNs in exploring osteoclast biology and further define the functional role of osteoclastic beta 1 integrin(s)
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Co ma z tym wspólnego szkoła? Krytyczna analiza roli szkoły w kontekście zjawiska bullyingu
No full textThis theoretical article addresses the compound word school bullying by asking the question, ‘what’s school got to do with it?’ Despite a vast amount of research into the phenomenon of school bullying, there has been relatively little focus on the importance of the school half of the open compound. Taking a critical educational perspective to school bullying (Horton, 2018), the article considers the importance of school to school bullying by discussing the social ecology of school and particularly the importance of the school environment (Bronfenbrenner, 1979). In doing so, the article uses examples from a recently completed ethnographic research project conducted in Swedish schools to elucidate the importance of key features of schools (Duncan, 2013; Eriksson et al., 2002), the different layers of schools (Gordon & Lahelma, 1996), as well as the environmental and structural elements of schools (Zumbrunn et al., 2013). The article provides an empirically-based theoretical framework for critically addressing the school in school bullying and argues that school bullying cannot be adequately addressed by only focusing on the behavioural side of the open compound. School is not simply the setting for school bullying. School means more than that.W artykule podjęto temat złożonego zjawiska bullyingu – prześladowania i dręczenia szkolnego. Postawiono pytanie: „Co ma z tym wspolnego szkoła?” Pomimo licznych badań nad bullyingiem w szkole, stosunkowo niewiele uwagi poświęcono roli, jaką kontekst szkolny odgrywa w powstawaniu i utrzymywaniu bullyingu. Przyjmując krytyczną perspektywę edukacyjną (Horton, 2018), autor rozważa rolę szkoły w tym zjawisku, analizując społeczną ekologię, w szczególności złożone środowisko szkolne (Bronfenbrenner, 1979). W artykule wykorzystano przykłady z niedawno zakończonego etnograficznego projektu badawczego przeprowadzonego w szwedzkich szkołach, aby wyjaśnić znaczenie kluczowych cech szkół (Duncan, 2013; Eriksson i in., 2002), rożnych warstw i poziomów w szkołach (Gordon & Lahelma, 1996), a także elementów środowiskowych i strukturalnych (Zumbrunn i in., 2013). Artykuł dostarcza teoretycznych ram opartych na badaniach empirycznych, które pozwalają na krytyczne ujęcie roli szkoły w zjawisku bullyingu. Argumentuje, że nie możemy skutecznie zapobiegać bullyingowi, skupiając się jedynie na behawioralnym aspekcie zjawiska. Szkoła to coś więcej niż tylko miejsce, w którym dochodzi do bullyingu – jej rola jest znacznie bardziej złożona
Stratigraphic significance of Upper Devonian and Lower Carboniferous miospores from the type area of the Horton Group, Nova Scotia
No full text Late Devonian (late Famennian) miospores have been found in the lowermost 7.3 m of the Horton Group on Harding Brook in the type area, Windsor Subbasin, Nova Scotia, below Tournaisian miospores of the Emphanisporites rotatus – Indotriradites explanatus Zone. Extending the age of the Horton Group in the type area down into the latest Devonian shows that the lowest beds of the ~ 1000 m thick group are coeval with latest Devonian rocks elsewhere in the Maritimes Basin that have been excluded from the Horton Group by some authors. Evidence presented here favours the argument that Late Devonian rocks lithologically similar to the Horton Group, deposited on the Acadian unconformity, should be included in that group. Miospore evidence indicates a minimum age of about 355 Ma for exhumation of the northeastern part of the South Mountain Batholith. </jats:p
Determination of cellular strains by combined atomic force microscopy and finite element modeling
No full textAbstractMany organs adapt to their mechanical environment as a result of physiological change or disease. Cells are both the detectors and effectors of this process. Though many studies have been performed in vitro to investigate the mechanisms of detection and adaptation to mechanical strains, the cellular strains remain unknown and results from different stimulation techniques cannot be compared. By combining experimental determination of cell profiles and elasticities by atomic force microscopy with finite element modeling and computational fluid dynamics, we report the cellular strain distributions exerted by common whole-cell straining techniques and from micromanipulation techniques, hence enabling their comparison. Using data from our own analyses and experiments performed by others, we examine the threshold of activation for different signal transduction processes and the strain components that they may detect. We show that modulating cell elasticity, by increasing the F-actin content of the cytoskeleton, or cellular Poisson ratio are good strategies to resist fluid shear or hydrostatic pressure. We report that stray fluid flow in some substrate-stretch systems elicits significant cellular strains. In conclusion, this technique shows promise in furthering our understanding of the interplay among mechanical forces, strain detection, gene expression, and cellular adaptation in physiology and disease
Exploring Emptiness: An Investigation of MA and MU in My Sonic Composition Practice
No full textThe commentary investigates Japanese aesthetics of space, silence and emptiness - ma and mu - that informed my compositional practice during the research period 2012 - 2015. The portfolio comprises text compositions and sound installations in which forms of micro events and sustained events are employed. Throughout, the emphasis is on my personal engagement with, and manifestation of emptiness that concerns a particular model of listening and perception.
Chapter 1 discusses six primary research areas: ma and mu, material, text, form, listening and perception. Firstly, I introduce ma and mu by examining noh culture and Zeami's teaching of senu hima (where there is no-action) in the context of my personal approaches to music. The following subjects are then used to contextualise my PhD practice by means of examples from various composers and visual artists. Here, these particular and enigmatic concepts are explored through Japanese art as well as Western contemporary works by Alvin Lucier, Eliane Radigue and those of the Wandelweiser collective.
Part 2 provides contextual commentaries on selected compositions from the portfolio that mostly articulate my aesthetics in relation to the topics covered in Chapter 1. koso koso addresses my methodologies to investigate the essence of senu hima, followed by treow that discusses my approach to materials and the importance of space. I move on to grade two and grade two extended in order to examine text scores, and then, look into Espèces d'espaces 03 and 04 as examples of musical forms that I employ.
Finally, listening and perception are investigated through the compositions gnome and con.de.structuring. Throughout, I describe how my works explore emptiness as a result of my particular emphasis on listening over composing
Stratigraphy and structure of the Horton Group, Lochaber-Mulgrave area, northern mainland Nova Scotia
No full textThe Lochaber-Mulgrave area of northern mainland Nova Scotia is underlain by rocks of the Late Devonian - Early Carboniferous Horton Group, in faulted contact with older Devonian and Silurian rocks to the south and west, and younger Carboniferous rocks to the north and east. The Horton Group is divided into (from oldest to youngest) the Clam Harbour River, Tracadie Road, Caledonia Mills, and Steep Creek formations, with a total thickness of at least 4000 m. These units were deposited in a variety of braided fluvial and shallow to deep lacustrine environments, and show lithological and stratigraphic similarities to the Horton Group elsewhere in Nova Scotia. Sparse palaeonto-logical data from macrofossils and spores indicate an age range from Famennian to late Tournaisian. Compared to elsewhere in Nova Scotia, the Horton Group in the Lochaber-Mulgrave area is more deformed and metamorphosed, especially in the southern part of the area near the Roman Valley Fault. The time of regional deformation and meta-morphism is constrained to ca. 340– 335 Ma by whole-rock 40Ar/39Ar dating of slate in the Clam Harbour River and Tracadie Road formations. Regional deformation and metamorphism may have resulted from burial by older rocks of the Guysborough block, thrust over the Horton Group in the Lochaber-Mulgrave area from the south as a result of transpression at a restraining bend along the Chedabucto-Roman Valley fault system during juxtaposition of the Avalon and Meguma terranes.
RÉSUMÉ
Le secteur de Lochaber-Mulgrave dans le nord de l'intérieur de la Nouvelle-Écosse repose sur des roches du groupe du Dévonien tardif au Carbonifère précoce de Horton, en contact faillé avec des roches du Dévonien et du Silurien au sud et à l'ouest, et avec des roches carbonifères au nord et à l'est. Le groupe de Horton se subdivise en (de la plus ancienne à la plus récente) formations de Clam Harbour River, de Tracadie Road, de Caledonia Mills et de Steep Creek, d'une épaisseur totale d'au moins 4 000 mètres. Ces unités se sont déposées au sein de divers environnements lacustres allant de peu profonds à profonds et d'environnements fluviaux anastomosés; elles présentent des similarités lithologiques et stratigraphiques avec le groupe de Horton ailleurs en Nouvelle-Écosse. Des données paléontologiques éparses tirées de macrofossiles et de spores révèlent une fourchette d'âges du Famennien au Tournaisien tardif. Comparativement aux autres régions de la Nouvelle-Écosse, le groupe de Horton dans le secteur de Lochaber-Mulgrave est plus déformé et métamorphisé, en particulier dans la partie méridionale du secteur, près de la faille de la vallée Roman. Le moment de la déformation et du métamorphisme régionaux se trouve restreint à environ 340-335 Ma par la datation 40Ar/39Ar de roche totale de l'ardoise dans les formations de Clam Harbour River et de Tracadie Road. La déformation et le métamorphisme régionaux pourraient avoir découlé de l'enfouissement de roches plus anciennes du bloc de Guysborough, qui chevauche le groupe de Horton dans le secteur de Lochaber-Mulgrave à partir du sud, par suite d'une transpression dans une inflexion de retenue le long du système de failles de Chedabucto-vallée Roman pendant la juxtaposition des terranes d'Avalon et de Megum
Protracted (~30Ma) eclogite-facies metamorphism in northern Victoria Land (Antarctica): Implications for the geodynamics of the Ross/Delamerian Orogen
No full textNorthern Victoria Land, Antarctica, plays a key role in any geodynamic reconstructions of the paleo-Pacific margin of Gondwana because it represents the along-strike continuation of Australia in Antarctica and hosts the only Paleozoic eclogites known along the Transantarctic Mountains. The architecture and evolution of the early Cambrian to Early Ordovician Ross–Delamerian Orogen in northern Victoria Land, however, remain controversial. Accurate geodynamic reconstructions have been hindered by a dearth of temporal metamorphic constraints. This study reports laser-ablation split-stream ICP-MS data on zircon in newly recognized eclogite, that preserves a memory of the prograde evolution, and on zircon from its country rock from the Lanterman Range of northern Victoria Land. Geochronological data are supplemented for the eclogite by whole-rock geochemical and petrological constraints, that indicate an E-MORB protolith derived from a depleted mantle source, and P–T conditions for the eclogite-facies stage of ~ 700 °C and 1.7–2.4 GPa. U–Pb ages, trace-element contents, cathodoluminescence imaging and textural/inclusion relationships testify to protracted zircon growth/recrystallization history under eclogite-facies conditions, that also included (re)crystallization during part of the prograde path. Results extend the onset of eclogite-facies metamorphism in northern Victoria Land back to ~ 530 Ma and, together with geochronological evidence for the emplacement of calc-alkaline granitoids at ~ 530–520 Ma, suggest that UHP–HP rocks formed by accretion of material beneath an active continental margin. Regionally, this interpretation implies that burial of mafic rocks and associated siliciclastic sequences to mantle depths commenced significantly earlier than previously believed (~ 500 Ma), thereby contrasting with the common belief that high-pressure metamorphism was linked to arc–continent collision. New and old results reveal the coexistence along the same ridge of two eclogite types: (1) medium-grained, “colder” and undeformed eclogites, that recorded both prograde and peak conditions, and (2) finer-grained, “hotter” and slightly deformed eclogites, that recorded only metamorphic peak conditions with hints of the subsequent retrogression. We propose that “prograde/peak” eclogites formed during an active continental margin stage and “peak” eclogites during the subsequent island arc–continental arc collision
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
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