24,539 research outputs found
PEER D9.13 Final Report
No full textPEER (Publishing and the Ecology of European Research), supported by the EC eContentplus programme, has been investigating the potential effects of the large-scale, systematic depositing of authors' final peer-reviewed manuscripts (so called Green Open Access or stage-two research output) on reader access, author visibility, and journal viability, as well as on the broader ecology of European research. The project ran from 1 September 2008 - 31 May 2012. This is PEER final report
PEER D9.13 Final Report
No full textPEER (Publishing and the Ecology of European Research), supported by the EC eContentplus programme, has been investigating the potential effects of the large-scale, systematic depositing of authors' final peer-reviewed manuscripts (so called Green Open Access or stage-two research output) on reader access, author visibility, and journal viability, as well as on the broader ecology of European research. The project ran from 1 September 2008 - 31 May 2012. This is PEER final report
Peer Review for Journals: Evidence on Quality Control, Fairness, and Innovation
No full textI reviewed the published empirical evidence concerning journal peer review, which consisted of 68 papers, all but three published since 1975. Peer review improves quality, but its use to screen papers has met with limited success. Current procedures to assure quality and fairness seem to discourage scientific advancement, especially important innovations, because findings that conflict with current beliefs are often judged to have defects. Editors can use procedures to encourage the publication of papers with innovative findings such as invited papers, early-acceptance procedures, author nominations of reviewers, results-blind reviews, structured rating sheets, open peer review, and, in particular, electronic publication. Some journals are currently using these procedures. The basic principle behind the proposals is to change the decision from whether to publish a paper to how to publish itpeer review, journals, publications
PEER D7.1b Additional Outcomes
No full textThe overriding aim of the PEER Project has been to investigate the effects of large-scale green open access. This has entailed building an infrastructure by involving publishers and repositories, designing an author deposit interface and enhancing the user experience. The means whereby the PEER Project has achieved its aims have engendered further results and reflections, thus adding value to the PEER Project. The following is a collection of these additional outcomes. Each outcome is independent
PEER D7.1b Additional Outcomes
No full textThe overriding aim of the PEER Project has been to investigate the effects of large-scale green open access. This has entailed building an infrastructure by involving publishers and repositories, designing an author deposit interface and enhancing the user experience. The means whereby the PEER Project has achieved its aims have engendered further results and reflections, thus adding value to the PEER Project. The following is a collection of these additional outcomes. Each outcome is independent
SNARE function is not involved in early endosome docking.
No full textDocking and fusion of transport vesicles constitute elementary steps in intracellular membrane traffic. While docking is thought to be initiated by Rab-effector complexes, fusion is mediated by SNARE (N-ethylmaleimide-sensitive factor [NSF] attachment receptor) proteins. However, it has been recently debated whether SNAREs also play a role in the establishment or maintenance of a stably docked state. To address this question, we have investigated the SNARE dependence of docking and fusion of early endosomes, one of the central sorting compartments in the endocytic pathway. A new, fluorescence-based in vitro assay was developed, which allowed us to investigate fusion and docking in parallel. Similar to homotypic fusion, docking of early endosomes is dependent on the presence of ATP and requires physiological temperatures. Unlike fusion, docking is insensitive to the perturbation of SNARE function by means of soluble SNARE motifs, SNARE-specific F(ab) fragments, or by a block of NSF activity. In contrast, as expected, docking is strongly reduced by interfering with the synthesis of phosphatidyl inositol (PI)-3 phosphate, with the function of Rab-GTPases, as well as with early endosomal autoantigen 1 (EEA1), an essential tethering factor. We conclude that docking of early endosomes is independent of SNARE function
Limited intermixing of synaptic vesicle components upon vesicle recycling.
No full textSynaptic vesicles recycle repeatedly in order to maintain synaptic transmission. We have previously proposed that upon exocytosis the vesicle components persist as clusters, which would be endocytosed as whole units. It has also been proposed that the vesicle components diffuse into the plasma membrane and are then randomly gathered into new vesicles. We found here that while strong stimulation (releasing the entire recycling pool) causes the diffusion of the vesicle marker synaptotagmin out of synaptic boutons, moderate stimulation (releasing similar to 19% of all vesicles) is followed by no measurable diffusion. In agreement with this observation, synaptotagmin molecules labeled with different fluorescently tagged antibodies did not appear to mix upon vesicle recycling, when investigated by subdiffraction resolution stimulated emission depletion (STED) microscopy. Finally, as protein diffusion from vesicles has been mainly observed using molecules tagged with pH-sensitive green fluorescent protein (pHluorin), we have also investigated the membrane patterning of several native and pHluorin-tagged proteins. While the native proteins had a clustered distribution, the GFP-tagged ones were diffused in the plasma membrane. We conclude that synaptic vesicle components intermix little, at least under moderate stimulation, possibly because of the formation of clusters in the plasma membrane. We suggest that several pHluorin-tagged vesicle proteins are less well integrated in clusters
PEER D4.1 Behavioural Research: Authors and Users vis-à-vis Journals and Repositories - Baseline report
No full textThe Behavioural research: Authors and users vis-à-vis journals and repositories project was commissioned by PEER in April 2009 as part of a broader initiative to investigate the effects of the large-scale, systematic deposit of authors' final peer-reviewed manuscripts (also called stage-two research outputs) on reader access, author visibility, and journal viability, as well as on the broader ecology of European research. The specific aim of the behavioural research is to understand the extent to which authors and users are aware of open access (OA), the different ways of achieving it, and the (de)motivating factors that influence its uptake
PEER D4.1 Behavioural Research: Authors and Users vis-à-vis Journals and Repositories - Baseline report
No full textThe Behavioural research: Authors and users vis-à-vis journals and repositories project was commissioned by PEER in April 2009 as part of a broader initiative to investigate the effects of the large-scale, systematic deposit of authors' final peer-reviewed manuscripts (also called stage-two research outputs) on reader access, author visibility, and journal viability, as well as on the broader ecology of European research. The specific aim of the behavioural research is to understand the extent to which authors and users are aware of open access (OA), the different ways of achieving it, and the (de)motivating factors that influence its uptake
Peer Networking and Community Change: Improving Foundation Practice
No full text· This article brings together the Annie E. Casey Foundation’s 15 years of experience with peer networking— examining through two research studies the process of peer networking and its impact, both with community-based and funder groups.
· Peer networking helps people with common interests to exchange information, disseminate good practices, and build a leadership structure for work they do together, such as a community change initiative.
· Casey’s research identified 10 good practices for effective peer networking, as well as 10 challenges that can affect its success; a four-level model was created to provide context for these findings.
· The research indicates that peer networking can have significant impact for communities and in meeting philanthropic goals, but it is costly and must be carefully structured if it is to be successful.
· Casey is working to synthesize its peer networking practices into a more strategic framework, and other foundations might use some of its lessons learned to enhance their own practices in this area
- …
