2,632 research outputs found
G2 & G1 plants species of SW Colorado
No full textPresented at the 16th symposium held on September 27, 2019 in Grand Junction, Colorado.2019 G2 species of SW Colorado -- 2019 G1 species of SW Colorado
Dynamics and thermodynamics of ligand-protein interactions
No full textProtein–ligand interactions are of fundamental importance in a great many biological processes. However, despite enormous advances in the speed and accuracy of the three-dimensional structure determination of proteins and their complexes, our ability to predict binding affinity from structure remains severely limited. One reason for this dilemma is that affinities are governed not only by energetic considerations arising from the precise spatial disposition of interacting groups (loosely, enthalpy), but also by the dynamics of these groups (loosely, entropy) including solvent effects. In this work I will review current methodology for unravelling this complex problem, including X-ray crystallography, NMR, isothermal titration calorimetry and theoretical free energy perturbation methods
Dependence of unsaturated chloride diffusion on the pore structure in cementitious materials
No full textConceptual analysis is performed to examine the effects of pore features on the water continuity in unsaturated porous systems. The roles of pore features in relative chloride diffusion coefficient (Drc) of mortar specimens at various degrees of water saturation (Sw) were studied based on mercury intrusion porosimetry and resistivity tests. It is found that the role of pore structure in the Drc-Sw relationship is a result of its effect on the water continuity. Porosity and tortuosity are not relevant to the Drc-Sw relationship. A finer pore size distribution or lower pore connectivity tends to result in a lower Drc. The pore size effect on the Drc is pronounced primarily at high Sw, while the Drc is dominated by the pore connectivity at low Sw. Cement mortar with a higher water-to-binder ratio shows larger chloride diffusion at high relative humidity levels but smaller chloride diffusion at low relative humidity levels.Accepted Author ManuscriptMaterials and Environmen
Total Cost of Ownership for Application Replatform by Open-source SW
No full textAbstractIn intra-company IT environment, the use of open-source software (OSS) should be expanded to reduce IT costs and to establish SW governance. This requires the migration of systems from the existing commercial SW to open-source SW, but the attempt of application replatform is prevented by the expenses for application reprogramming and data migration. This study proposes a methodology for TCO calculation of application replatform using open-source SW. In practice, a five-year TCO shows a cost reduction effect of 78% - 83%. This TCO could be further reduced if the application size is increased due to data accumulation and the company gets open-source SW capabilities internally. In addition, it is possible to directly apply an application developed from open-source SW to a virtualized infrastructure environment, which enables to operate in a hybrid cloud environment. This enables a scalable, efficient and flexible IT operation and a sustainable TCO reduction in the futur
Residual 2H Quadrupolar couplings in weakly aligned carbohydrates
No full textWe report a novel two-dimensional NMR pulse scheme for the 1H-detected observation of 2H in isotopically 13C, 2H-enriched carbohydrates. This scheme is used for the indirect observation of residual quadrupolar couplings in 13C, 2H-enriched methyl-β--glucopyranoside weakly aligned in a dilute lyotropic liquid-crystalline medium comprising 20% (w/v) dihexanoyl-phos- phatidylcholine/dimyristoyl-phosphatidylcholine (1:3 mol/mol) in D2O. The observed residual quadrupolar couplings are substantially larger than residual dipolar one-bond 13C–1H couplings under the same experimental conditions. These quadrupolar couplings are thus a useful alternative to dipolar couplings for the structural analysis of small molecules that align very weakly in dilute liquid-crystalline media. Moreover, since the quadrupolar coupling constant is very uniform throughout endocyclic deuterons of the carbohydrate, these data suggest that adoption of a single average value of this parameter in 2H relaxation studies on the glycan moieties of glycoproteins and glycopeptides is a valid assumption
Review of previous meetings, Part 3: Montrose, SW Colorado, G2G3 species
No full textSymposium held on September 28, 2012 in Canyon City, Colorado.Title from website.2008 Montrose: SW Colorado G2G3 species -- 2009 Loveland: NW & central Colorado G2G3 species
Review of previous meetings, Part 3: SW Colorado G2, NW Colorado G2 species
No full textSymposium held on September 23, 2016 in Boulder, Colorado.Title page states Golden, Colorado, should be Boulder, Colorado.Title from website.2008/2016 SW Colorado G2G3 species -- 2009/2014 NW & central Colorado G2G3 species
- …
