1,940 research outputs found
Cognition in hepatitis C patients treated with pegylated interferon
No full textNeuropsychiatric symptoms are frequently reported by patients with chronic hepatitis C during treatment with interferon (IFN)-alpha and may lead to treatment discontinuation. In order to assess the objective neuropsychiatric impairments we prospectively administered standardized neuropsychological testing before and 3 months after the initiation of antiviral treatment with pegylated IFN-alpha in 17 patients suffering from chronic hepatitis C. In addition depression and anxiety scores, social functioning and hepatological parameters were obtained. While depressive and anxiety symptoms increased significantly during treatment only subtle worsening in neurocognitive performance could be detected, indicating slight impairment in cognitive flexibility and psychomotor speed (Trail Making Test B; 69.6+/-23 s before vs. 80.7+/-31 s during therapy, P = 0.011, not remaining significant after Bonferroni correction). We found no association between reduced neurocognitive performance and the severity of depression. Better neurocognitive performance in single domains was associated with better response to antiviral treatment measured as the decline of elevated liver enzymes (AST). We conclude that neurocognitive performance was influenced by antiviral IFN-alpha-based combination treatment only in single domains and not to a clinically relevant extent in contrast to the significant worsening of depression
Poetische Gedächtnis
No full textihr e. Weissheit auss Pflichtschuldigkeit von unterschidlichen glükwünschenden Personen, theils im Truck, theils geschriben übergeben, und jez, nach ergangener Wahl des Herren Sohns zum Burgermeisterthum also zusamen gebracht.Enthält Gedichte von Joh. Jacob Breitinger, Joh. Wilhelm Ziegler, Joh. Jacob Irminger, Joh. Rudolf Stucki, Johannes Wirz, Hans Caspar Suter, Georg Müller, Hans Caspar Wolf, Joh. Peter Zindel, Caspar Gessner, Bernhard Hofmann, Joh. Rudolf Brunner, Rudolf Hospinian, Johannes Jacob Genath, Hans Heinrich Schweizer u.a
Sportliches Engagement und jugendliche Identität
No full textKurz D, Brinkhoff K-P. Sportliches Engagement und jugendliche Identität. In: Brettschneider W-D, ed. Sport im Alltag von Jugendlichen. Texte, Quellen, Dokumente zur Sportwissenschaft ; 24. Schorndorf: Hofmann; 1989: 95-113
In pursuit of the lone wolf terrorist: investigative economics and new horizons for the economic analysis of terrorism
No full textThis book explores new horizons for the economic analysis of terrorism with an innovative combination of economics and offender profiling. The book is aimed at contributing to law enforcement efforts to pre-empt and pursue the lone wolf terrorist. By taking the economic analysis of terrorism back to its core concepts of 'opportunities' and 'choices' and by insisting that all results be both computable and relevant to the investigative process, the author examines lone wolf terrorism from a unique perspective that yields new insights into the nature of the lone wolf terrorist's opportunities and choices to inflict human tragedy. Not content with the task of delineating opportunities and choices, the author shows how the frameworks he has developed may be inverted and deployed in the pursuit of the lone wolf terrorist if efforts to pre-empt the lone wolf terrorist have failed. This book is groundbreaking for both the type of economics analysis it presents and its conscious break with several long-held traditions of terrorism studies. Both academics and law enforcement practitioners will find the author's analysis stimulating, confronting and, above all, applicable to the investigative processes designed to pre-empt or pursue a single violent offender who aims to etch a graphic biography of violence into the public consciousness
Impact of centralized evaluation of bone marrow histology in systemic mastocytosis
No full textBACKGROUND:Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM).MATERIALS AND METHODS: Within the 'German Registry of Disorders on Eosinophils and Mast Cells', we identified 65 SM patients who had two consecutive BM biopsies. The first biopsy was evaluated by a local pathologist (LP), the second biopsy by a reference pathologist (RP) of the 'European Competence Network on Mastocytosis (ECNM)'.RESULTS: Final diagnoses by RP were SM (n = 27), SM or aggressive SM (ASM) with associated non-mast cell lineage hematologic disease [(A)SM-AHNMD, n = 34)] or mast cell leukemia ± AHNMD (n = 4). In 15/65 patients (23%), initial diagnoses by LP were incorrect (by overlooking SM), e.g. primary myelofibrosis (n = 3), myelodysplastic/myeloproliferative neoplasm unclassified (n = 3), B-cell lymphoma (n = 2). Fourteen of 15 patients (93%) with incorrect diagnosis had an advanced SM, mostly (A)SM-AHNMD. In the 50 concordantly diagnosed patients, immunohistochemical markers for quantitative assessment of mast cell infiltration, e.g. CD117 (KIT) or CD25, were applied by LP in only 34/50 patients (68%), and mutational analysis for KIT D816V was performed or recommended in only 13/50 patients (26%). Finally, the subclassification of SM was discordant because LP did not diagnose AHNMD in 9/50 (18%) patients.CONCLUSIONS: In summary, adequate diagnosis and subclassification of SM requires an in-depth evaluation of the BM by experienced hematopathologists (preferably in a reference center) in combination with molecular genetics, serum tryptase and clinical parameters
A Tell-Me-A-Story Keepsake Treasury
No full textHere is a curiosity. I found a book earlier with all the same bibliographical information except its ISBN. Now I happened to find this book. When I checked whether I already had added the same book to the collection, I noticed my remark that the book I had found first was almost square. This book, by contrast, is about 9 x 12. It also adds a page facing the bibliographical information. On this page there are lines to fill in with the name of the person who gave the book and one's favorite story, character, and picture. The rectangular presentation of the three pigs on both covers there is here circular. This is a second printing. Can the format have changed from one printing to the other? In any case, here is what I wrote back then: Holeinone and Wolf are back. About half of the forty stories here on 224 pages are fables. The production of the book seems physically solid, the paper sturdy, and the graphics quite sharp. Questions interspersed with the text and framed to stand apart raise good issues, like these on 21: Do you think the crab and the fish can trust the heron to help? Why or why not? The crab in this case does not kill the heron. MSA is presented as What Other People Think. The first stage here is to carry the donkey in a wheelbarrow (172). Are the fable illustrations new or details of Wolf's earlier work? I revise my earlier statement to say now that I am surprised to learn that I have sixteen other books on which the two collaborated.This is a hardbound book (hard cover)Second printingWritten by Peter Holeinon
Grains of Sound: Visual and Sonic Textures in <i>Sand or Peter and the Wolf</i>
No full text There is a tendency in animation studies to discuss sound in the language of images, stressing sound’s alignment with visual cues (as in mickey mousing and leitmotifs). But sounds do not only mimic images: they add textures and emotions that change what we see. This article explores grain (texture) and timbre (tone color produced by specific instruments and techniques) as qualities shared by visual and sonic material. To do so, the author closely reads Sand or Peter and the Wolf (1969), where Caroline Leaf’s haptic sand animation is matched by Michael Riesman’s electroacoustic score. Leaf painstakingly molds animals by scraping away individual sand grains, and Riesman sculpts sonic textures with tiny adjustments to knobs and touch-sensitive pads on the Buchla modular synthesizer. Their collective improvisation with sands and sounds reveals new ways to think about artists’ material practices and the friction and interplay between images and sounds. They encourage spectators to perceive the animals as not merely plasmatic, or Sergei Eisenstein’s notion of contour-bending character animation. Instead, Leaf and Riesman deploy what the author calls ‘granular modulation’, expressing sand and animals with sensuous materiality. In Leaf’s and Riesman’s improvisations, grainy textures are the seeds of understanding how sound and vision become symbiotic – and encounter friction – in animation. </jats:p
La figure de Peter Pan ou le refus du corps vécu : de la clinique du vide dans la mélancolie
No full textNational audienceA phenomenological and psychoanalytical approach of the novels' person Peter Pan and the circumstances of the creation by the author in studying the analogies between the biographical elements of the author and splitting in different persons in the novel but also in Peter Pan himself. The infantile drama of the child being rejected by his mother because of the death of a former child, his brother, enacting psychical fragmentation up to experience annihilationUne approche phénoménologique et psychanalytique du personnage romanesque de Peter Pan et les circonstances de création par son auteur en effectuant des analogies entre les éléments biographiques de l'auteur et les clivages des personnages du roman mais aussi du personnage Peter Pan en lui-même. Le drame infantile du rejet de l'enfant par la mère suite au décès d'un enfant lui précédant, le frère, donne ici lieu à des fragmentations psychiques jusqu'au vécu de l'anéantissement
Haptic training: Which types facilitate (re)learning of which motor task and for whom Answers by a review
No full textThe use of robots has attracted researchers to design numerous haptic training methods to support motor learning. However, investigations of new methods yielded inconclusive results regarding their effectiveness to enhance learning due to the diversity of tasks, haptic designs, participants skill level, and study protocols. In this review, we developed a taxonomy to identify generalizable findings out of publications on haptic training. In the taxonomy, we grouped the results of studies on healthy learners based on participants skill level and tasks characteristics. Our inspection of included studies revealed that: i) Performance-enhancing haptic methods were beneficial for novices, ii) Training with haptics was as effective as training with other feedback modalities, and iii) Performance-enhancing and performance-degrading haptic methods were useful for the learning of temporal and spatial aspects, respectively. We also observed that these findings are in line with results from robot-aided neurorehabilitation studies on patients. Our review suggests that haptic training can be effective to foster learning, especially when the information cannot be provided with other feedback modalities. We believe the findings from the taxonomy constitute a general guide, which can assist researchers when designing studies to investigate the effectiveness of haptics on learning different tasks.Accepted Author ManuscriptHuman-Robot Interactio
Contes et Fables du Monde Entier
No full textThis book is in the same series as my Le Lievre et la Tortue et autres histoires by the same author and illustrator, but with a different French translator. The one fable here is Le Renard, le Serpent et le Paysan. It is illustrated very well. The old man is almost gnomish. The story's end surprises me. The peasant invites the fox to come by in the evening to receive his reward. His reward is to face the peasant's two dogs. The fox realizes, too late, that the serpent was right. Good deeds are always rewarded with bad ones! ©Dami Editore.This is a hardbound book (hard cover)Language note: FrenchOriginal language: itaText: Peter Holeinone; Adaptation Française de M. Bonoli-Bégui
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