568 research outputs found
Correction to
Get PDFThe article “Intermittent levosimendan infusion in ambulatory patients with end‑stage heart failure: a systematic review and meta‑analysis of 984 patients”, written by Hagar Elsherbini, Osama Soliman, Casper Zijderhand, Mattie Lenzen, Sanne E. Hoeks, Rasha Kaddoura, Mohamed Izham5, Abdulaziz Alkhulaifi, Amr S. Omar, and Kadir Caliskan, was originally published electronically on the publisher’s internet portal on 11 April 2021 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 10 June 2021 to</p
Argon does not affect cerebral circulation or metabolism in male humans.
Get PDFOBJECTIVE:Accumulating data have recently underlined argon´s neuroprotective potential. However, to the best of our knowledge, no data are available on the cerebrovascular effects of argon (Ar) in humans. We hypothesized that argon inhalation does not affect mean blood flow velocity of the middle cerebral artery (Vmca), cerebral flow index (FI), zero flow pressure (ZFP), effective cerebral perfusion pressure (CPPe), resistance area product (RAP) and the arterio-jugular venous content differences of oxygen (AJVDO2), glucose (AJVDG), and lactate (AJVDL) in anesthetized patients. MATERIALS AND METHODS:In a secondary analysis of an earlier controlled cross-over trial we compared parameters of the cerebral circulation under 15 minutes exposure to 70%Ar/30%O2 versus 70%N2/30%O2 in 29 male patients under fentanyl-midazolam anaesthesia before coronary surgery. Vmca was measured by transcranial Doppler sonography. ZFP and RAP were estimated by linear regression analysis of pressure-flow velocity relationships of the middle cerebral artery. CPPe was calculated as the difference between mean arterial pressure and ZFP. AJVDO2, AJVDG and AJVDL were calculated as the differences in contents between arterial and jugular-venous blood of oxygen, glucose, and lactate. Statistical analysis was done by t-tests and ANOVA. RESULTS:Mechanical ventilation with 70% Ar did not cause any significant changes in mean arterial pressure, Vmca, FI, ZFP, CPPe, RAP, AJVDO2, AJVDG, and AJVDL. DISCUSSION:Short-term inhalation of 70% Ar does not affect global cerebral circulation or metabolism in male humans under general anaesthesia
sj-pdf-1-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm
No full textSupplemental material, sj-pdf-1-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine</p
sj-pdf-2-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm
No full textSupplemental material, sj-pdf-2-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine</p
sj-pdf-3-vmj-10.1177_1358863X231181159 – Supplemental material for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm
No full textSupplemental material, sj-pdf-3-vmj-10.1177_1358863X231181159 for Circulating biomarkers of cardiovascular disease are related to aneurysm volume in abdominal aortic aneurysm by Elke Bouwens, Alexander Vanmaele, Sanne E Hoeks, Hence JM Verhagen, Bram Fioole, Adriaan Moelker, Sander ten Raa, Burhan Hussain, José Oliveira-Pinto, Frederico Bastos Gonçalves, Arne S Ijpma, Imo E Hoefer, Felix van Lier, K Martijn Akkerhuis, Danielle F Majoor-Krakauer, Eric Boersma and Isabella Kardys in Vascular Medicine</p
Understanding the child : A mental needs manual for caretakers in children’s homes
Get PDFGiving adequate care for children in children’s homes (we prefer the expression “children’s home” to “orphanage”, since there are few institutions where all the children are real orphans) is very demanding and difficult. Therefore, a child should not be placed in a children’s home unless it is impossible for his biological family to take care of him, and unless it is impossible to provide him with adoptive parents or a foster home. However, the reality is that a large number of children grow up in children’s homes. The aim of this manual is to contribute to the equipment of caregivers working in such institutions. It has been developed in an Asian context, but we hope that it can be useful also in other parts of the world. We believe the following to be true: What I hear, I forget. What I see, I remember. What I do, I know. What I discover, I use. Therefore, when teaching caregiving staff from this manual, we hope that the teachers will allow time for their students to reflect on, and when possible, discover themselves the principles of these teachings. Also, both practical skills and attitudes need to be demonstrated. For these reasons we hope that the content of this book will be passed on to the staff on an individual basis or in small groups, and in a practical way. Time and again we stress that children need individual attention and training. So do caregivers, to a certain extent, to adopt healthy attitudes and to develop their caregiving skills. The title “Understanding the child” has been chosen because we believe that understanding brings about love and compassion, the most important ingredients in child rearing. We have made our best to base the teaching on up-to-date research and literature. (This has also caused some of the content to be rather complicated and detailed.) However, it has been unavoidable to introduce information that is less objective and acknowledged. Whether you are a Buddhist, a Hindu, a Muslim, a Christian, an atheist or profess another faith or religion, we hope that you will find this book useful. The author himself is a Christian and finds much relevant information about child rearing in the Bible. However, all biblical references and examples are marked with an asterisk (*), to show those not interested what they can skip when reading. In this manner the rest of the text is free from religious content. Hopefully you will find the structure of this book logical. Firstly, to understand the child it is important to have some knowledge on child development (section 3). Secondly, we need to know about children’s rights and needs (section 4). Thirdly, it is time to study how children’s homes should be organised to prepare for these needs to be met (section 5). Fourthly, we will see how caretakers can fulfil the basic needs of children (section 6). In our view, this is the most important section of the book. Fifthly, there will be teachings on some common problems that children may face, particularly in residential care, and what you can do to help them out (section 7). It is very important to study section 6 carefully (The basics of child rearing) before you apply the principles given in section 7 (Some problems and what you can do). The structure of each chapter is simple: For most subjects there is a summary of the teaching, then the teaching itself, followed by some references to the Bible, marked* (Bible version: the New International Version if not otherwise stated). There will also be some suggestions to work tasks that can be carried out to improve the care of the children. Finally, main references have been listed. In some chapters we have included information that may be useful without being essential. Such information is printed in this size letters. To make the text more readable we have chosen to use “he” instead of “he/she” when referring to a child or another person. If anyone should wonder about this choice, it does not express any prejudice on our part. Also, as you have already noted, the author uses “we” (instead of “I”) to refer to himself. The word “reward” is often used instead of the technically more correct expression “reinforcement”, because the latter is a concept that is more difficult to explain and translate. The definitions of and difference between these concepts are found in chapter 7.3. Major changes have been made from the first edition (which has just been translated into the Myanmar language) to the second. The following chapters are new: 3.3 Development of school-age children, 6.6 Teaching problem solving, emotional regulation and friendship skills, 7.6 Some specific behavioural problems, 7.8 HIV and AIDS, 7.9 Some academic problems, 7.10 Problems related to natural functions, and 8.2 Resources. Except from 7.9 and 7.10, the content of these chapters is entirely new. We have also expanded chapter 6.5 considerably. Behavioural problems have been devoted four chapters (7.3-7.6) because of their frequency, and because of the importance of handling these problems in an appropriate way. Minor revisions and expansions have also been done for several of the other chapters
Perioperative Cardiac Care: From Guidelines to Clinical Practice
Get PDFCardiovascular disease is the major cause of death and disability in the Western world. The main
disease underlying cardiovascular disorders is atherosclerosis. Atherosclerosis is a systemic
disease affecting numerous vascular beds, including the coronary and peripheral circulation
i.e. cerebrovascular, aortic and lower limb arterial circulation. The global ageing phenomenon
will further increase the burden of cardiovascular disease and also enforce a change in health
care towards the elderly population. Peripheral arterial disease (PAD) is a common condition.
Importantly, only 1 out of 9 patients with PAD are symptomatic while vascular morbidity and
mortality is estimated to be similar in patients with symptomatic or asymptomatic PAD. This
poses PAD to be a major health burden. Risk factors for atherosclerotic disease are common and
polyvascular disease is highly prevalent in the PAD population. The prognosis of patients with PAD
is predominantly determined by the presence and extent of the underlying ischemic heart disease
(IHD). The estimated cardiovascular risk in PAD is, moreover, as high as in IHD.3,4 Mc Dermott
and colleagues reported already in 1997 that PAD patients received less intensive drug treatment
compared to IHD patients, irrespective of comparable risk. Additionally, in a large risk factor
matched population, patients with IHD received more cardiac medications, compared with PAD
patients (beta-blockers 74% vs. 34%, aspirin 88% vs. 40%, nitrates 37% vs. 19%, statins 67% vs. 29% and
ACE-inhibitors 57% vs. 31%, respectively). The observed poor medical control of PAD patients may
be an explanation for the worse outcome of PAD patients compared with IHD patients as observed
by the study of Welten et al. The REACH registry showed that cardiovascular events increased in
a stepwise fashion with the number of symptomatic vascular beds.4 The combined 1-year outcome
of atherothrombotic events ranged from 17% in patients with PAD as a single affected vascular bed
to 26% in patients with 3 diseased vascular beds. Patients with PAD undergoing vascular surgery
are known to be at higher risk for both early and late cardiovascular events compared to patients
with IHD.3,7 Hertzer’s landmark study in 1000 consecutive patients undergoing surgery for PAD
who underwent preoperative cardiac catheterizations reported that only 8% had normal coronary
arteries, and approximately one third had severe-correctable or severe-inoperable IHD
Author Correction:Vitamin D status and severity of COVID-19 (Scientific Reports, (2022), 12, 1, (19823), 10.1038/s41598-022-21513-9)
Get PDFSanne Grundvald Boelt was omitted from the author list in the original version of this Article. The Author Contributions section now reads: “A.A. contributed to the conception and idea of the work. N.M.N., A.S.C., L.B. and A.A. contributed to the design of the study. N.M.N., A.S.C., L.B. S.G.B contributed to the acquisition of data. N.M.N., A.H., L.B., S.G.B and T.G.J. contributed to the analyses of the data. All authors contributed to the interpretation of the data and the results in the manuscript. N.M.N. drafted the manuscript, made Fig. 1, T.G.J. made Fig. 2. All the authors revised the manuscript critically and has approved the final version.” The original Article has been corrected.</p
Author Correction: Considerations in the search for epistasis
No full textFollowing publication of the original article [1], the authors identified that two author affiliations were incorrect. Joséphine Daub is affiliated with Utrecht University (21) and not affiliation 9. Sanne Abeln is affiliated with Utrecht University only (21) and not affiliation 1. The original article [1] has been corrected.</p
Risk Assessment in Cardiovascular Disease: A biomarker tale?
Get PDFIn this thesis, we investigated the potency of circulating biomarkers to improve prognostication in patients with cardiovascular disease. The focus was on patients with chronic heart failure and vascular diseases, in particular abdominal aortic aneurysms
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