1,798 research outputs found

    The construction of Karen Karnak: The multi-author-function

    No full text
    This thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author

    Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria

    No full text
    Purpose: Immunotherapeutic agents produce antitumor effects by inducing cancer-specific immune responses or by modifying native immune processes. Resulting clinical response patterns extend beyond those of cytotoxic agents and can manifest after an initial increase in tumor burden or the appearance of new lesions (progressive disease). Response Evaluation Criteria in Solid Tumors or WHO criteria, designed to detect early effects of cytotoxic agents, may not provide a complete assessment of immunotherapeutic agents. Novel criteria for the evaluation of antitumor responses with immunotherapeutic agents are required. Experimental Design: The phase II clinical trial program with ipilimumab, an antibody that blocks CTL antigen-4, represents the most comprehensive data set available to date for an immunotherapeutic agent. Novel immune therapy response criteria proposed, based on the shared experience from community workshops and several investigators, were evaluated using data from ipilimumab phase II clinical trials in patients with advanced melanoma. Results: Ipilimumab monotherapy resulted in four distinct response patterns: (a) shrinkage in baseline lesions, without new lesions; (b) durable stable disease (in some patients followed by a slow, steady decline in total tumor burden); (c) response after an increase in total tumor burden; and (d) response in the presence of new lesions. All patterns were associated with favorable survival. Conclusion: Systematic criteria, designated immune-related response criteria, were defined in an attempt to capture additional response patterns observed with immune therapy in advanced melanoma beyond those described by Response Evaluation Criteria in Solid Tumors or WHO criteria. Further prospective evaluations of the immune-related response criteria, particularly their association with overall survival, are warranted. (Clin Cancer Res 2009;15(23):7412-20

    FSD-FS

    No full text
    FSD-FS is a publicly-available database of human labelled sound events for few-shot learning. It spans across 143 classes obtained from the AudioSet Ontology and contains 43805 raw audio files collected from the FSD50K. FSD-FS is curated at the Centre for Digital Music, Queen Mary University of London. Citation If you use the FSD-FS dataset, please cite our paper and FSD50K. @article{liang2022learning, title={Learning from Taxonomy: Multi-label Few-Shot Classification for Everyday Sound Recognition}, author={Liang, Jinhua and Phan, Huy and Benetos, Emmanouil}, journal={arXiv preprint arXiv:2212.08952}, year={2022} } @ARTICLE{9645159, author={Fonseca, Eduardo and Favory, Xavier and Pons, Jordi and Font, Frederic and Serra, Xavier}, journal={IEEE/ACM Transactions on Audio, Speech, and Language Processing}, title={FSD50K: An Open Dataset of Human-Labeled Sound Events}, year={2022}, volume={30}, number={}, pages={829-852}, doi={10.1109/TASLP.2021.3133208}} About FSD-FS FSD-FS is an open database for multi-label few-shot audio classification containing 143 classes drawn from the FSD50K. It also inherits the AudioSet Ontology. FSD-FS follows the ratio 7:2:1 to split classes into base, validation, and evaluation sets, so there are 98 classes in the base set, 30 classes in the validation set, and 15 classes in the evaluation set (More details can be found in our paper). LICENSE FSD-FS are released in Creative Commons (CC) licenses. Same as FSD50K, each clip has its own license as defined by the clip uploader in Freesound, some of them requiring attribution to their original authors and some forbidding further commercial reuse. For more details, ones can refer to the link. FILES FSD-FS are organised in the structure: root | └─── dev_base | └─── dev_val | └─── eval REFERENCES AND LINKS [1] Gemmeke, Jort F., et al. "Audio set: An ontology and human-labeled dataset for audio events." 2017 IEEE international conference on acoustics, speech and signal processing (ICASSP). IEEE, 2017. [paper] [link] [2] Fonseca, Eduardo, et al. "Fsd50k: an open dataset of human-labeled sound events." IEEE/ACM Transactions on Audio, Speech, and Language Processing 30 (2021): 829-852. [paper] [code

    Tissue architecture of the anterior pituitary showing the epithelial cell cords with hormonal cells and folliculo-stellate (FS) cells, the capillaries (C) with fenestrated endothelial cells (EC) and connective tissue (CT)

    No full text
    <p><b>Copyright information:</b></p><p>Taken from "Paracrinicity: The Story of 30 Years of Cellular Pituitary Crosstalk"</p><p></p><p>Journal of Neuroendocrinology 2008;20(1):1-70.</p><p>Published online Jan 2008</p><p>PMCID:PMC2229370.</p><p>© 2008 The Author. Journal Compilation © 2008 Blackwell Publishing Ltd</p> The cell cords are a cluster of endocrine cells surrounding an aggregate of FS cells that make a follicle (F). FS cells also make a meshwork between the hormonal cells, making junctions among each other (thick lines) and extending foot processes (f) ending on the basal membrane (BM) in the periphery of the cord. The cords are surrounded by BM, which may have extensions between some cells. A second BM surrounds the capillary vessels and between these two some connective tissue resides. Small and larger lacunae are present between hormonal cells. Paracrine substances may circulate from cell-to-cell but also could be released in these lacunae and reach more remote places. FS cells make gap junctions mostly among each other, but occasionally also with some hormonal cells. Hormonal cells can make interdigitations with FS cells (small arrows) to favour cell-to-cell communication. Adapted from Vila-Porcile ()

    Adaptive pulse compression for transform-limited 15-fs high-energy pulse generation

    No full text
    We demonstrate the use of a deformable-mirror pulse shaper, combined with an evolutionary optimization algorithm, to correct high-order residual phase aberrations in a 1-mJ, 1-kHz, 15-fs laser amplifier. Frequency resolved optical gating measurements reveal that the output pulse duration of 15.2 fs is within our measurement error of the theoretical transform limit. This technique significantly reduces the pulse duration and the temporal prepulse energy of the pulse while increasing the peak intensity by 26%. It is demonstrated, for what is believed to be the first time, that the problem of pedestals in laser amplifiers can be addressed by spectral-domain correction

    Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide

    No full text
    Nonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s

    Sub-40 fs Er:fiber laser

    No full text
    Simulation and experiment results are presented for sub-40 fs pulse generation in Er: fiber ring lasers. (C) 2010 Optical Society of Americahttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295612401079&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, Electrical &amp; ElectronicOpticsPhysics, AppliedCPCI-S(ISTP)

    Time-domain investigation of the ro-vibrational CH<sub>4</sub> v<sub>2</sub> Raman spectrum via fs/ps CRS for combustion diagnostics

    No full text
    With the onset of climate change it is crucial to eliminate emissions, particularly for aviation reliant on gas turbine combustion. Computational models aid combustor improvement, but experimental data needed for validation is difficult to obtain. Fortunately, laser diagnostics can now achieve non-intrusive, high-resolution combustion measurements, especially with hybrid femtosecond/picosecond (fs/ps) coherent Raman scattering (CRS). In this thesis, the goal was to develop hybrid fs/ps CRS spectroscopy for the CH4 ν2 vibrational mode. Methane merits investigation as a climate forcer alongside potential use in carbon-neutral hydrogen production. Time-resolved CRS was performed for collision-independent, collisional dephasing, and laminar CH4-air flame measurements. A time-domain model well-reproduced experiments, along with extracting molecule-specific ν2 Q-branch dephasing linewidth parameters. Additionally, fundamental physio-chemical processes were observed in a spectral molecular fingerprint region across the CH4-air flame: CH4 dissociation, H2 synthesis and consumption, mass diffusion, and fuel/oxidizer mixing.Aerospace Engineerin

    La Fabrique des classiques africains: écrivains d’Afrique subsaharienne francophone . Par Ducournau Claire

    No full text
    This is a pre-copyedited, author-produced PDF of an article accepted for publication in French Studies following peer review. The version of record Claire H Griffiths (2018) La Fabrique des classiques africains : ecrivains d'Afrique subsaharienne francophone par Claire Ducournau, French Studies, Volume 72, Issue 2, 1 April 2018, Pages 318–319 is available online at: https://doi.org/10.1093/fs/kny023The review article evaluates major new scholarship on the development of the French literary system in colonial and postcolonial Africa and its impact on Francophone writing

    The case for a symmetric reaction function of the European Central Bank

    No full text
    In a macro-economic framework where the European Central Bank targets individual country data, the nature of strategic interactions between fiscal authorities in the euro-zone can be described as a stag hunt game with (at least) two equilibria that can be pareto-ranked. In fact we show that, because of the indiscriminate nature of its monetary response, an ECB strategy of monetary retaliation to any individual countrys over-expenditure affects all eleven countries to the same extent. This collective effect is similar to the teachers old favorite all children stay behind in the class if one misbehaves. This mechanism, we show, makes the game between fiscal authorities a multiple equilibria co-ordination game. We subsequently address the problem of equilibrium selection that is of particular importance to co-ordination games. Following Kandori et al. (1993), we apply Harsanyi and Seltens (1988) riskdominance criterion to single out the conditions for fiscal restraint to emerge as the equilibrium selected by interacting actors. Our main conclusions are that the ECB can ensure convergence of fiscal authorities upon the pareto-optimal equilibrium (that is, fiscal restraint) by adopting a reward-oriented, counter-cyclical strategy that compensates fiscal authorities at the output level both for giving up fiscal discretion and for incurring the risk of being hit by a monetary tightening in response to developments elsewhere in the euro-economy. This means that interest rates' movements should smoothen economic fluctuations in order to give economic actors sufficient incentives to maintain restraint. -- In einem makroökonomischen Kontext, in dem die Europäische Zentralbank die wirtschaftlichen Daten einzelner Länder anvisiert, können die strategischen Interaktionen zwischen den Finanzbehörden der Euro-Zone als ein stag hunt- Spiel mit (mindestens) zwei pareto-Equilibrien beschrieben werden. Wir zeigen daß, aufgrund der ungezielten Art der monetären Reaktion, eine EZB-Strategie der monetären Vergeltung für zu hohe Ausgaben eines einzelnen Landes alle elf Länder gleichermaßen betrifft. Dieser Kollektiveffekt erinnert an die alte Lehrermethode: Alle Kinder müssen nachsitzen, wenn eins aus der Reihe tanzt. Dieser Mechanismus macht das Spiel zwischen den Finanzbehörden zu einem Koordinationsspiel mit mehreren Equilibrien. Anschließend befassen wir uns mit dem in Koordinationsspielen besonders bedeutsamen Problem der Wahl zwischen Equilibrien. In Anlehnung an Kandori et al. (1993) wenden wir Harsanyi und Selten's (1988) Risikodominanzkriterium an, um die Bedingungen herauszufiltern, unter denen fiskale Zurückhaltung das Equilibrium bildet, das von den beteiligten Akteuren gewählt wird. Unsere wesentlichen Schlußfolgerungen sind, daß die EZB eine Konvergenz der Finanzbehörden auf das pareto-optimale Equilibrium (d.h. fiskale Zurückhaltung) sicherstellen kann, indem sie eine auf Belohnung ausgerichte, antizyklische Strategie verfolgt, bei der die Finanzbehörden auf der Output-Ebene entschädigt werden -sowohl für die Abgabe fiskaler Entscheidungsfreiheit als auch für das Risiko, einer monetären Kontraktion ausgesetzt zu werden, die auf Entwicklungen anderswo in der Euro-Wirtschaft abzielt. Das bedeutet, daß Zinsentwicklungen wirtschaftliche Fluktuationen ausgleichen sollten, um den relevanten Akteuren ausreichende Anreize für fiskale Zurückhaltung zu bieten.
    corecore