3 research outputs found
Formulation and nutritional evaluation of galactagogue-based nutritional health mixes to support lactation
No full textBackground: Human breast milk is a rich source of essential nutrients and also contains protective elements such as antibodies and immune factors, along with hormones, growth factors, enzymes, and other bioactive compounds, which are designed for easy digestion and optimal absorption, ensuring the best possible growth and development of infants. However, dysgalactia or insufficient milk production, often linked to inadequate intake of calories and essential nutrients necessary for milk production, is a common hindrance to breastfeeding. In this context, the current study was planned to design and develop different variations of finger millet and oats-based galactagogue health mixes with the intent to encourage milk synthesis.
Methods: Four galactagogue health mixes, namely GHM-R1, GHM-R2, GHM-O1 and GHM-O2 based on finger millet (25 and 50%) and oats (25 and 50%) with nuts and seeds, were developed. Foxnut flour-based health mix was used as a control. A descriptive sensory score card was used for sensory analysis. AOAC methods were used to analyse proximate and dietary fibre. Calcium and iron were analysed using standard protocols.
Results: Among the developed galactagogue health mixes, the sensory quality of GHM-R1 (25% popped finger millet) was found to be highly acceptable with a score of 8.45. GHM-R2 (50% popped finger millet) reported the highest calcium content, 328 mg/100 gm.
Conclusions: There lies great scope in scientifically evaluating the traditional knowledge systems based galactagogues for the mechanism, efficacy, dose, and safety.
Modelling of groundwater quality using bicarbonate chemical parameter in Netravathi and Gurpur river confluence, India
No full textEvaluation of clopidogrel on acute and sub-acute models of inflammation in male Wistar rats
No full textBackground: Atherosclerosis and its complications remain the major cause of death and premature disability. Atherogenesis involves elements of inflammation, a process that now provides a unifying theme in the pathogenesis of the disease. Anti-platelet drugs are currently used in the treatment of atherosclerosis and its complications. Our study evaluated the influence of clopidogrel on acute and sub-acute models of inflammation in male Wistar rats.Methods: Male Wistar rats (150-200 g) were divided into three groups, i.e. control, aspirin and clopidogrel (n=6 animals in each group). The effect of clopidogrel administered orally on inflammation was studied using acute (carrageenan-induced rat paw edema) and sub-acute (cotton pellet granuloma and histopathological examination of grass piths) models. Experiment was conducted according to the Committee for the Purpose of Control and Supervision on Experiments on Animals guidelines. Analysis was done using one-way ANOVA followed by post-hoc test of Dunnets. p<0.05 was considered as statistically significant.Results: Clopidogrel showed significant inhibition of rat paw edema in acute model (p<0.01) and granuloma dry weight, in sub-acute model of inflammation when compared to control (p<0.01). Histopathological examination of grass pith revealed markedly reduced fibroblasts, granulation tissue, fibrous tissue and collagen in clopidogrel group when compared to control.Conclusion: Clopidogrel exhibited a significant anti-inflammatory activity in acute and sub-acute models of inflammation
