1,721,118 research outputs found
Deciding on Gender in Children with Intersex Conditions
No full textBiologic factors such as genetic and hormonal influences contribute to gender identity, gender role behavior, and sexual orientation in humans, but this relationship is considerably modified by psychologic, social, and cultural factors. The recognition of biologically determined conditions leading to incongruity of genetically determined sex, somatic phenotype, and gender identity has led to growing interest in gender role development and gender identity in individuals with intersex conditions. Sex assignment of children with ambiguous genitalia remains a difficult decision for the families involved and subject to controversial discussion among professionals and self-help groups. Although systematic empirical data on outcomes of functioning and health-related quality of life are sparse, anecdotal evidence from case series and individual patients about their experiences in healthcare suggests traumatic experiences in some. This article reviews the earlier ‘optimal gender policy’ as well as the more recent ‘full consent policy’ and reviews published data on both surgical and psychosocial outcomes. The professional debate on deciding on sex assignment in children with intersex conditions is embedded in a much wider public discourse on gender as a social construction. Given that the empirical basis of our knowledge of the causes, treatment options, long-term outcomes, and patient preferences is insufficient, we suggest preliminary recommendations based on clinical experience, study of the literature, and interviews with affected individuals
Disorders of Sex Development and Hypogonadism: Genetics, Mechanism, and Therapies
Full text linkDisorders of sex development (DSD) and hypogonadism are genetically heterogeneous and include a broad spectrum of phenotypes. Recent advances in biology and medicine have introduced impressive improvements in both clinical management and structured research, mainly in new technologies to study their genetic features and the mechanisms underlying their pathologies. Knowledge and understanding of these conditions have led to the development of successful therapies and novel tools to characterize them and provide better care to patients. Therefore, both DSD and hypogonadism represent an important field in research and clinical setting.Fil: Guerra Jr., Gil. Universidade Estadual de Campinas; BrasilFil: Latronico, Ana Claudia. Universidade de Sao Paulo; BrasilFil: Hiort, Olaf. Universität zu Lübeck; AlemaniaFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentin
Somatische Entwicklung von Kindern nach assistierter Reproduktion unter Berücksichtigung ihres genetischen Wachstumspotentials
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Molekulargenetische Untersuchungen bei Patienten mit X-chromosomal dominanter hypophosphatämischer Rachitis
No full textdissecting central versus peripheral actions of thyroid hormones in a mouse model of the Allan-Herndon-Dudley Syndrome
No full textFunktionelle Analysen definierter Mutationen im Transkriptionsfaktor Steroidogenic Factor-1
No full textExom-Sequenzierung als moderne Diagnosemethode für Kinder mit unklaren neurologischen Entwicklungsstörungen
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Vervollständigung und Auswertung einer Datenbank zu seltenen genetisch bedingten Besonderheiten der Geschlechtsentwicklung (DSD)
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